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Gene: ZNF438 |
Gene summary for ZNF438 |
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Gene information | Species | Human | Gene symbol | ZNF438 | Gene ID | 220929 |
Gene name | zinc finger protein 438 | |
Gene Alias | bA330O11.1 | |
Cytomap | 10p11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q7Z4V0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
220929 | ZNF438 | NAFLD1 | Human | Liver | NAFLD | 4.66e-05 | 5.41e-01 | -0.04 |
220929 | ZNF438 | HCC1_Meng | Human | Liver | HCC | 3.72e-12 | -4.27e-02 | 0.0246 |
220929 | ZNF438 | HCC2_Meng | Human | Liver | HCC | 8.17e-03 | -2.62e-02 | 0.0107 |
220929 | ZNF438 | S027 | Human | Liver | HCC | 5.39e-03 | 4.67e-01 | 0.2446 |
220929 | ZNF438 | S028 | Human | Liver | HCC | 6.06e-12 | 5.62e-01 | 0.2503 |
220929 | ZNF438 | S029 | Human | Liver | HCC | 1.39e-10 | 5.56e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF438 | insertion | Frame_Shift_Ins | novel | c.1809_1810insGAAGTGGTGGTTGCAGACGTGACATCTGTGC | p.Gln604GlufsTer75 | p.Q604Efs*75 | Q7Z4V0 | protein_coding | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
ZNF438 | insertion | Frame_Shift_Ins | novel | c.1417_1418insACATTGG | p.Ser473TyrfsTer7 | p.S473Yfs*7 | Q7Z4V0 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF438 | SNV | Missense_Mutation | novel | c.691N>A | p.Gln231Lys | p.Q231K | Q7Z4V0 | protein_coding | tolerated(0.57) | benign(0.024) | TCGA-05-4390-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF438 | SNV | Missense_Mutation | novel | c.1959N>T | p.Gln653His | p.Q653H | Q7Z4V0 | protein_coding | deleterious(0) | possibly_damaging(0.725) | TCGA-44-3398-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF438 | SNV | Missense_Mutation | c.1453N>C | p.Asn485His | p.N485H | Q7Z4V0 | protein_coding | deleterious(0.01) | benign(0.254) | TCGA-44-3918-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ZNF438 | SNV | Missense_Mutation | c.1765N>A | p.Val589Met | p.V589M | Q7Z4V0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-1596-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
ZNF438 | SNV | Missense_Mutation | novel | c.333N>T | p.Met111Ile | p.M111I | Q7Z4V0 | protein_coding | tolerated(0.13) | benign(0) | TCGA-64-1677-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemcitabine | PD |
ZNF438 | SNV | Missense_Mutation | c.256N>T | p.Ala86Ser | p.A86S | Q7Z4V0 | protein_coding | deleterious(0.04) | benign(0.223) | TCGA-22-4591-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemzar | PD | |
ZNF438 | SNV | Missense_Mutation | novel | c.416T>A | p.Leu139Gln | p.L139Q | Q7Z4V0 | protein_coding | tolerated(0.5) | benign(0.014) | TCGA-22-4594-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF438 | SNV | Missense_Mutation | rs759541951 | c.836N>G | p.Asn279Ser | p.N279S | Q7Z4V0 | protein_coding | tolerated(1) | benign(0.001) | TCGA-34-2608-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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