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Gene: ZNF263 |
Gene summary for ZNF263 |
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Gene information | Species | Human | Gene symbol | ZNF263 | Gene ID | 10127 |
Gene name | zinc finger protein 263 | |
Gene Alias | FPM315 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O14978 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10127 | ZNF263 | LZE7T | Human | Esophagus | ESCC | 4.11e-03 | 1.10e-01 | 0.0667 |
10127 | ZNF263 | LZE20T | Human | Esophagus | ESCC | 1.05e-03 | 1.30e-01 | 0.0662 |
10127 | ZNF263 | LZE24T | Human | Esophagus | ESCC | 1.10e-15 | 3.48e-01 | 0.0596 |
10127 | ZNF263 | LZE21T | Human | Esophagus | ESCC | 5.66e-03 | 1.39e-01 | 0.0655 |
10127 | ZNF263 | P1T-E | Human | Esophagus | ESCC | 8.29e-04 | 3.64e-01 | 0.0875 |
10127 | ZNF263 | P2T-E | Human | Esophagus | ESCC | 5.62e-28 | 5.17e-01 | 0.1177 |
10127 | ZNF263 | P4T-E | Human | Esophagus | ESCC | 1.93e-03 | 1.62e-01 | 0.1323 |
10127 | ZNF263 | P5T-E | Human | Esophagus | ESCC | 4.73e-10 | 8.58e-02 | 0.1327 |
10127 | ZNF263 | P8T-E | Human | Esophagus | ESCC | 5.16e-11 | 2.38e-01 | 0.0889 |
10127 | ZNF263 | P9T-E | Human | Esophagus | ESCC | 1.03e-09 | 1.35e-01 | 0.1131 |
10127 | ZNF263 | P10T-E | Human | Esophagus | ESCC | 4.90e-10 | 2.13e-01 | 0.116 |
10127 | ZNF263 | P11T-E | Human | Esophagus | ESCC | 1.24e-10 | 5.18e-01 | 0.1426 |
10127 | ZNF263 | P12T-E | Human | Esophagus | ESCC | 3.49e-17 | 4.17e-01 | 0.1122 |
10127 | ZNF263 | P15T-E | Human | Esophagus | ESCC | 5.35e-16 | 3.72e-01 | 0.1149 |
10127 | ZNF263 | P16T-E | Human | Esophagus | ESCC | 1.53e-17 | 1.83e-01 | 0.1153 |
10127 | ZNF263 | P17T-E | Human | Esophagus | ESCC | 2.28e-03 | 1.39e-01 | 0.1278 |
10127 | ZNF263 | P19T-E | Human | Esophagus | ESCC | 1.64e-05 | 2.47e-01 | 0.1662 |
10127 | ZNF263 | P20T-E | Human | Esophagus | ESCC | 4.23e-13 | 2.69e-01 | 0.1124 |
10127 | ZNF263 | P21T-E | Human | Esophagus | ESCC | 2.21e-14 | 1.66e-01 | 0.1617 |
10127 | ZNF263 | P22T-E | Human | Esophagus | ESCC | 3.06e-16 | 2.28e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF263 | SNV | Missense_Mutation | novel | c.1825G>C | p.Gly609Arg | p.G609R | O14978 | protein_coding | tolerated(0.09) | probably_damaging(0.964) | TCGA-77-8146-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF263 | SNV | Missense_Mutation | novel | c.808N>A | p.Val270Met | p.V270M | O14978 | protein_coding | tolerated(0.12) | benign(0.03) | TCGA-98-7454-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF263 | SNV | Missense_Mutation | c.601C>T | p.Pro201Ser | p.P201S | O14978 | protein_coding | tolerated(0.93) | benign(0) | TCGA-J1-A4AH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF263 | SNV | Missense_Mutation | novel | c.1963N>A | p.Gly655Arg | p.G655R | O14978 | protein_coding | deleterious(0.03) | probably_damaging(0.985) | TCGA-O2-A52S-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZNF263 | insertion | Frame_Shift_Ins | novel | c.1163_1164insT | p.Asn389Ter | p.N389* | O14978 | protein_coding | TCGA-68-7755-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unspecific | SD | |||
ZNF263 | SNV | Missense_Mutation | rs755474014 | c.1520N>A | p.Arg507Gln | p.R507Q | O14978 | protein_coding | tolerated(0.17) | possibly_damaging(0.806) | TCGA-BA-5555-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZNF263 | SNV | Missense_Mutation | novel | c.97N>A | p.Pro33Thr | p.P33T | O14978 | protein_coding | deleterious(0.04) | benign(0.116) | TCGA-CQ-5334-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF263 | SNV | Missense_Mutation | rs138118006 | c.1753C>T | p.Arg585Trp | p.R585W | O14978 | protein_coding | deleterious(0.02) | benign(0.425) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF263 | SNV | Missense_Mutation | c.1613G>T | p.Arg538Ile | p.R538I | O14978 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ZNF263 | SNV | Missense_Mutation | c.207N>T | p.Trp69Cys | p.W69C | O14978 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-BR-A4J4-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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