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Gene: ZNF185 |
Gene summary for ZNF185 |
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Gene information | Species | Human | Gene symbol | ZNF185 | Gene ID | 7739 |
Gene name | zinc finger protein 185 with LIM domain | |
Gene Alias | SCELL | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B3KPM4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7739 | ZNF185 | C04 | Human | Oral cavity | OSCC | 5.08e-07 | 3.98e-01 | 0.2633 |
7739 | ZNF185 | C21 | Human | Oral cavity | OSCC | 1.56e-39 | 1.22e+00 | 0.2678 |
7739 | ZNF185 | C30 | Human | Oral cavity | OSCC | 1.77e-16 | 7.75e-01 | 0.3055 |
7739 | ZNF185 | C43 | Human | Oral cavity | OSCC | 7.81e-17 | 4.10e-01 | 0.1704 |
7739 | ZNF185 | C46 | Human | Oral cavity | OSCC | 3.60e-12 | 2.77e-01 | 0.1673 |
7739 | ZNF185 | C51 | Human | Oral cavity | OSCC | 4.86e-14 | 5.45e-01 | 0.2674 |
7739 | ZNF185 | C57 | Human | Oral cavity | OSCC | 9.77e-28 | 9.34e-01 | 0.1679 |
7739 | ZNF185 | C08 | Human | Oral cavity | OSCC | 1.69e-02 | 1.52e-01 | 0.1919 |
7739 | ZNF185 | C09 | Human | Oral cavity | OSCC | 1.74e-04 | 1.17e-01 | 0.1431 |
7739 | ZNF185 | SYSMH1 | Human | Oral cavity | OSCC | 4.27e-07 | 2.51e-01 | 0.1127 |
7739 | ZNF185 | SYSMH3 | Human | Oral cavity | OSCC | 2.09e-11 | 2.77e-01 | 0.2442 |
7739 | ZNF185 | SYSMH4 | Human | Oral cavity | OSCC | 2.38e-02 | 1.38e-01 | 0.1226 |
7739 | ZNF185 | SYSMH5 | Human | Oral cavity | OSCC | 2.21e-07 | 1.95e-01 | 0.0647 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF185 | SNV | Missense_Mutation | c.1510N>T | p.Thr504Ser | p.T504S | O15231 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF185 | SNV | Missense_Mutation | rs368172395 | c.184N>A | p.Ala62Thr | p.A62T | O15231 | protein_coding | tolerated(0.06) | probably_damaging(0.941) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF185 | SNV | Missense_Mutation | rs782678540 | c.1411N>A | p.Ala471Thr | p.A471T | O15231 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF185 | SNV | Missense_Mutation | rs782634433 | c.1997N>A | p.Arg666His | p.R666H | O15231 | protein_coding | tolerated(0.08) | benign(0.006) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
ZNF185 | SNV | Missense_Mutation | c.1931N>C | p.Lys644Thr | p.K644T | O15231 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF185 | SNV | Missense_Mutation | c.2150N>T | p.Tyr717Phe | p.Y717F | O15231 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EM-A22P-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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