GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:00434343 | Colorectum | FAP | response to peptide hormone | 100/2622 | 414/18723 | 1.74e-08 | 1.84e-06 | 100 |
GO:19016533 | Colorectum | FAP | cellular response to peptide | 89/2622 | 359/18723 | 2.93e-08 | 2.64e-06 | 89 |
GO:00713753 | Colorectum | FAP | cellular response to peptide hormone stimulus | 75/2622 | 290/18723 | 5.60e-08 | 4.29e-06 | 75 |
GO:00328683 | Colorectum | FAP | response to insulin | 68/2622 | 264/18723 | 2.71e-07 | 1.55e-05 | 68 |
GO:00328693 | Colorectum | FAP | cellular response to insulin stimulus | 54/2622 | 203/18723 | 1.54e-06 | 6.59e-05 | 54 |
GO:0008286 | Colorectum | FAP | insulin receptor signaling pathway | 28/2622 | 116/18723 | 2.37e-03 | 1.89e-02 | 28 |
GO:00434344 | Colorectum | CRC | response to peptide hormone | 76/2078 | 414/18723 | 6.67e-06 | 2.56e-04 | 76 |
GO:00328684 | Colorectum | CRC | response to insulin | 53/2078 | 264/18723 | 1.30e-05 | 4.17e-04 | 53 |
GO:00328694 | Colorectum | CRC | cellular response to insulin stimulus | 42/2078 | 203/18723 | 4.79e-05 | 1.12e-03 | 42 |
GO:00713754 | Colorectum | CRC | cellular response to peptide hormone stimulus | 55/2078 | 290/18723 | 4.82e-05 | 1.12e-03 | 55 |
GO:19016534 | Colorectum | CRC | cellular response to peptide | 64/2078 | 359/18723 | 8.54e-05 | 1.75e-03 | 64 |
GO:00082861 | Colorectum | CRC | insulin receptor signaling pathway | 23/2078 | 116/18723 | 4.02e-03 | 3.33e-02 | 23 |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:003286918 | Esophagus | ESCC | cellular response to insulin stimulus | 124/8552 | 203/18723 | 6.63e-06 | 6.75e-05 | 124 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF10 | SNV | Missense_Mutation | | c.1300N>C | p.Glu434Gln | p.E434Q | P21506 | protein_coding | deleterious(0.05) | possibly_damaging(0.745) | TCGA-33-4547-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF10 | SNV | Missense_Mutation | novel | c.32G>T | p.Arg11Leu | p.R11L | P21506 | protein_coding | tolerated(0.15) | benign(0.013) | TCGA-39-5034-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF10 | SNV | Missense_Mutation | novel | c.529G>T | p.Ala177Ser | p.A177S | P21506 | protein_coding | tolerated(1) | benign(0.001) | TCGA-56-8625-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
ZNF10 | SNV | Missense_Mutation | novel | c.1579N>G | p.Ser527Gly | p.S527G | P21506 | protein_coding | deleterious(0.01) | benign(0.012) | TCGA-56-A62T-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
ZNF10 | deletion | Frame_Shift_Del | novel | c.160+1delG | | | P21506 | protein_coding | | | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF10 | SNV | Missense_Mutation | novel | c.454N>G | p.Phe152Val | p.F152V | P21506 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-CN-4735-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vectibix | SD |
ZNF10 | SNV | Missense_Mutation | novel | c.1582C>A | p.Gln528Lys | p.Q528K | P21506 | protein_coding | tolerated(0.64) | benign(0.007) | TCGA-CN-6010-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF10 | SNV | Missense_Mutation | novel | c.785N>T | p.Glu262Val | p.E262V | P21506 | protein_coding | deleterious(0) | possibly_damaging(0.73) | TCGA-CR-7401-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF10 | SNV | Missense_Mutation | | c.730N>A | p.Asp244Asn | p.D244N | P21506 | protein_coding | tolerated(0.5) | benign(0) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
ZNF10 | SNV | Missense_Mutation | novel | c.716A>T | p.Lys239Ile | p.K239I | P21506 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-CV-6441-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |