![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZFR2 |
Gene summary for ZFR2 |
![]() |
Gene information | Species | Human | Gene symbol | ZFR2 | Gene ID | 23217 |
Gene name | zinc finger RNA binding protein 2 | |
Gene Alias | KIAA1086 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9UPR6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23217 | ZFR2 | C43 | Human | Oral cavity | OSCC | 1.06e-36 | 6.15e-01 | 0.1704 |
23217 | ZFR2 | C46 | Human | Oral cavity | OSCC | 2.20e-33 | 5.91e-01 | 0.1673 |
23217 | ZFR2 | C57 | Human | Oral cavity | OSCC | 1.42e-24 | 5.13e-01 | 0.1679 |
23217 | ZFR2 | C86 | Human | Oral cavity | OSCC | 4.47e-05 | 4.84e-01 | 0.161 |
23217 | ZFR2 | LN22 | Human | Oral cavity | OSCC | 2.52e-10 | 7.71e-01 | 0.1733 |
23217 | ZFR2 | LN46 | Human | Oral cavity | OSCC | 7.43e-28 | 8.15e-01 | 0.1666 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFR2 | SNV | Missense_Mutation | c.452N>A | p.Pro151His | p.P151H | Q9UPR6 | protein_coding | deleterious(0.02) | possibly_damaging(0.57) | TCGA-22-5491-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZFR2 | SNV | Missense_Mutation | novel | c.1244N>A | p.Arg415Lys | p.R415K | Q9UPR6 | protein_coding | tolerated(0.62) | benign(0.05) | TCGA-34-5241-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFR2 | SNV | Missense_Mutation | novel | c.2234N>T | p.Thr745Ile | p.T745I | Q9UPR6 | protein_coding | tolerated(0.19) | possibly_damaging(0.579) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFR2 | SNV | Missense_Mutation | rs763789976 | c.1876G>A | p.Asp626Asn | p.D626N | Q9UPR6 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-63-A5MI-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | vinorelbine | SD |
ZFR2 | SNV | Missense_Mutation | novel | c.2090N>T | p.Pro697Leu | p.P697L | Q9UPR6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-90-7769-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZFR2 | SNV | Missense_Mutation | novel | c.1583T>A | p.Leu528Gln | p.L528Q | Q9UPR6 | protein_coding | tolerated(0.18) | possibly_damaging(0.696) | TCGA-96-A4JK-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR |
ZFR2 | SNV | Missense_Mutation | novel | c.1459N>T | p.Val487Leu | p.V487L | Q9UPR6 | protein_coding | tolerated(1) | benign(0.125) | TCGA-98-A53A-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFR2 | SNV | Missense_Mutation | novel | c.1573N>A | p.Gln525Lys | p.Q525K | Q9UPR6 | protein_coding | deleterious(0.02) | possibly_damaging(0.564) | TCGA-NC-A5HN-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFR2 | SNV | Missense_Mutation | rs773375916 | c.1340C>T | p.Ala447Val | p.A447V | Q9UPR6 | protein_coding | tolerated(1) | benign(0.007) | TCGA-DQ-5624-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZFR2 | insertion | In_Frame_Ins | novel | c.1989_1990insTTGTGTAGTAAC | p.Ala663_Lys664insLeuCysSerAsn | p.A663_K664insLCSN | Q9UPR6 | protein_coding | TCGA-HD-8314-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |