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Gene: ZDBF2 |
Gene summary for ZDBF2 |
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Gene information | Species | Human | Gene symbol | ZDBF2 | Gene ID | 57683 |
Gene name | zinc finger DBF-type containing 2 | |
Gene Alias | Slx9 | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | N0DVX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57683 | ZDBF2 | LZE4T | Human | Esophagus | ESCC | 6.44e-07 | 2.97e-01 | 0.0811 |
57683 | ZDBF2 | LZE7T | Human | Esophagus | ESCC | 1.89e-08 | 5.99e-01 | 0.0667 |
57683 | ZDBF2 | P2T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.51e-01 | 0.1177 |
57683 | ZDBF2 | P9T-E | Human | Esophagus | ESCC | 3.65e-03 | 8.10e-02 | 0.1131 |
57683 | ZDBF2 | P10T-E | Human | Esophagus | ESCC | 7.90e-03 | 7.02e-02 | 0.116 |
57683 | ZDBF2 | P16T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.40e-01 | 0.1153 |
57683 | ZDBF2 | P22T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.53e-01 | 0.1236 |
57683 | ZDBF2 | P32T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.03e-01 | 0.1666 |
57683 | ZDBF2 | P37T-E | Human | Esophagus | ESCC | 3.04e-07 | 1.29e-01 | 0.1371 |
57683 | ZDBF2 | P48T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.07e-01 | 0.0959 |
57683 | ZDBF2 | P49T-E | Human | Esophagus | ESCC | 1.22e-03 | 6.53e-01 | 0.1768 |
57683 | ZDBF2 | P56T-E | Human | Esophagus | ESCC | 3.65e-05 | 6.51e-01 | 0.1613 |
57683 | ZDBF2 | P62T-E | Human | Esophagus | ESCC | 2.37e-05 | 9.93e-02 | 0.1302 |
57683 | ZDBF2 | P76T-E | Human | Esophagus | ESCC | 8.40e-04 | 7.63e-02 | 0.1207 |
57683 | ZDBF2 | P79T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.34e-01 | 0.1154 |
57683 | ZDBF2 | P107T-E | Human | Esophagus | ESCC | 1.41e-03 | 1.68e-01 | 0.171 |
57683 | ZDBF2 | P130T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.82e-01 | 0.1676 |
57683 | ZDBF2 | male-WTA | Human | Thyroid | PTC | 9.88e-08 | 6.31e-02 | 0.1037 |
57683 | ZDBF2 | PTC01 | Human | Thyroid | PTC | 1.69e-05 | 3.47e-02 | 0.1899 |
57683 | ZDBF2 | PTC04 | Human | Thyroid | PTC | 1.74e-06 | 1.92e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZDBF2 | SNV | Missense_Mutation | c.4938N>C | p.Lys1646Asn | p.K1646N | Q9HCK1 | protein_coding | tolerated(0.29) | benign(0.339) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZDBF2 | SNV | Missense_Mutation | rs757506025 | c.5069N>A | p.Arg1690Gln | p.R1690Q | Q9HCK1 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
ZDBF2 | SNV | Missense_Mutation | novel | c.5762N>T | p.Pro1921Leu | p.P1921L | Q9HCK1 | protein_coding | deleterious(0.04) | benign(0.382) | TCGA-AA-A02O-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | c.5434C>A | p.Pro1812Thr | p.P1812T | Q9HCK1 | protein_coding | tolerated(0.55) | benign(0) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZDBF2 | SNV | Missense_Mutation | c.5419G>A | p.Val1807Ile | p.V1807I | Q9HCK1 | protein_coding | tolerated(0.1) | benign(0.006) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZDBF2 | SNV | Missense_Mutation | novel | c.4505N>T | p.Ser1502Phe | p.S1502F | Q9HCK1 | protein_coding | deleterious(0) | probably_damaging(0.942) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | rs746951501 | c.5617N>G | p.Lys1873Glu | p.K1873E | Q9HCK1 | protein_coding | tolerated(1) | benign(0) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | c.984N>T | p.Lys328Asn | p.K328N | Q9HCK1 | protein_coding | deleterious(0.02) | possibly_damaging(0.865) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
ZDBF2 | SNV | Missense_Mutation | novel | c.5309N>A | p.Arg1770Lys | p.R1770K | Q9HCK1 | protein_coding | tolerated(0.82) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZDBF2 | SNV | Missense_Mutation | rs779996852 | c.310G>A | p.Glu104Lys | p.E104K | Q9HCK1 | protein_coding | tolerated(0.91) | benign(0.103) | TCGA-D5-6538-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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