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Gene: WIF1 |
Gene summary for WIF1 |
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Gene information | Species | Human | Gene symbol | WIF1 | Gene ID | 11197 |
Gene name | WNT inhibitory factor 1 | |
Gene Alias | WIF-1 | |
Cytomap | 12q14.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9Y5W5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11197 | WIF1 | HCC1 | Human | Liver | HCC | 1.76e-16 | 4.71e+00 | 0.5336 |
11197 | WIF1 | S014 | Human | Liver | HCC | 2.66e-13 | 7.91e-01 | 0.2254 |
11197 | WIF1 | S015 | Human | Liver | HCC | 1.98e-08 | 7.05e-01 | 0.2375 |
11197 | WIF1 | S016 | Human | Liver | HCC | 2.99e-15 | 1.17e+00 | 0.2243 |
11197 | WIF1 | RNA-P23T2-P23T2-1 | Human | Lung | MIAC | 4.45e-03 | -8.52e-02 | -0.037 |
11197 | WIF1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.30e-03 | -1.00e+00 | -0.2116 |
11197 | WIF1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.42e-02 | -1.01e+00 | -0.2119 |
11197 | WIF1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 4.28e-06 | -1.09e+00 | 0.1829 |
11197 | WIF1 | RNA-P3T-P3T-2 | Human | Lung | IAC | 1.27e-06 | -1.09e+00 | 0.1835 |
11197 | WIF1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 5.72e-07 | -1.09e+00 | 0.1859 |
11197 | WIF1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.84e-19 | -1.06e+00 | -0.0166 |
11197 | WIF1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.38e-18 | -1.05e+00 | -0.0132 |
11197 | WIF1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.45e-19 | -1.06e+00 | -0.013 |
11197 | WIF1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 7.02e-18 | -1.05e+00 | -0.0121 |
11197 | WIF1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 1.83e-05 | -6.39e-01 | -0.0876 |
11197 | WIF1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 5.13e-04 | -5.58e-01 | -0.0809 |
11197 | WIF1 | C08 | Human | Oral cavity | OSCC | 4.78e-06 | 6.85e-01 | 0.1919 |
11197 | WIF1 | SYSMH4 | Human | Oral cavity | OSCC | 5.86e-10 | 8.16e-01 | 0.1226 |
11197 | WIF1 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 7.89e-27 | 1.16e+00 | -0.1688 |
11197 | WIF1 | GSM5252129_BPH327PrSF_Via | Human | Prostate | BPH | 1.55e-09 | 9.91e-01 | -0.1697 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:019873821 | Liver | HCC | cell-cell signaling by wnt | 247/7958 | 446/18723 | 2.11e-08 | 4.96e-07 | 247 |
GO:001605521 | Liver | HCC | Wnt signaling pathway | 245/7958 | 444/18723 | 3.68e-08 | 8.09e-07 | 245 |
GO:003011121 | Liver | HCC | regulation of Wnt signaling pathway | 180/7958 | 328/18723 | 3.62e-06 | 4.72e-05 | 180 |
GO:00454441 | Liver | HCC | fat cell differentiation | 120/7958 | 229/18723 | 1.52e-03 | 8.05e-03 | 120 |
GO:00160556 | Lung | IAC | Wnt signaling pathway | 95/2061 | 444/18723 | 1.13e-10 | 2.80e-08 | 95 |
GO:01987386 | Lung | IAC | cell-cell signaling by wnt | 95/2061 | 446/18723 | 1.46e-10 | 3.48e-08 | 95 |
GO:00301116 | Lung | IAC | regulation of Wnt signaling pathway | 74/2061 | 328/18723 | 1.14e-09 | 2.05e-07 | 74 |
GO:00456002 | Lung | IAC | positive regulation of fat cell differentiation | 17/2061 | 66/18723 | 6.14e-04 | 8.46e-03 | 17 |
GO:00454443 | Lung | IAC | fat cell differentiation | 42/2061 | 229/18723 | 6.19e-04 | 8.50e-03 | 42 |
GO:00301783 | Lung | IAC | negative regulation of Wnt signaling pathway | 32/2061 | 170/18723 | 1.68e-03 | 1.76e-02 | 32 |
GO:001605512 | Lung | AIS | Wnt signaling pathway | 91/1849 | 444/18723 | 9.38e-12 | 5.47e-09 | 91 |
GO:019873812 | Lung | AIS | cell-cell signaling by wnt | 91/1849 | 446/18723 | 1.22e-11 | 6.13e-09 | 91 |
GO:003011112 | Lung | AIS | regulation of Wnt signaling pathway | 70/1849 | 328/18723 | 3.81e-10 | 8.87e-08 | 70 |
GO:003017811 | Lung | AIS | negative regulation of Wnt signaling pathway | 32/1849 | 170/18723 | 2.64e-04 | 5.05e-03 | 32 |
GO:004544411 | Lung | AIS | fat cell differentiation | 37/1849 | 229/18723 | 1.88e-03 | 2.08e-02 | 37 |
GO:00456001 | Lung | AIS | positive regulation of fat cell differentiation | 14/1849 | 66/18723 | 4.51e-03 | 3.99e-02 | 14 |
GO:003011122 | Lung | MIAC | regulation of Wnt signaling pathway | 41/967 | 328/18723 | 1.51e-07 | 3.69e-05 | 41 |
GO:001605531 | Lung | MIAC | Wnt signaling pathway | 50/967 | 444/18723 | 1.88e-07 | 4.02e-05 | 50 |
GO:019873831 | Lung | MIAC | cell-cell signaling by wnt | 50/967 | 446/18723 | 2.16e-07 | 4.11e-05 | 50 |
GO:00301782 | Lung | MIAC | negative regulation of Wnt signaling pathway | 19/967 | 170/18723 | 1.28e-03 | 2.38e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043108 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa0431011 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa0431021 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
hsa0431031 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
hsa0431041 | Lung | MIAC | Wnt signaling pathway | 21/507 | 171/8465 | 1.30e-03 | 1.40e-02 | 1.01e-02 | 21 |
hsa0431051 | Lung | MIAC | Wnt signaling pathway | 21/507 | 171/8465 | 1.30e-03 | 1.40e-02 | 1.01e-02 | 21 |
hsa0431014 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431015 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431023 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
hsa0431033 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WIF1 | SNV | Missense_Mutation | novel | c.524N>T | p.Lys175Ile | p.K175I | Q9Y5W5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-A4J5-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
WIF1 | SNV | Missense_Mutation | rs201325270 | c.650N>A | p.Arg217Gln | p.R217Q | Q9Y5W5 | protein_coding | tolerated(0.96) | benign(0) | TCGA-CD-5801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11197 | WIF1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, CELL SURFACE | Platinum compounds | 24980784 |
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