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Gene: VWA3A |
Gene summary for VWA3A |
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Gene information | Species | Human | Gene symbol | VWA3A | Gene ID | 146177 |
Gene name | von Willebrand factor A domain containing 3A | |
Gene Alias | VWA3A | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A6NCI4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146177 | VWA3A | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 5.87e-01 | -0.0238 |
146177 | VWA3A | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 5.54e-03 | 5.01e-01 | -0.0263 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VWA3A | SNV | Missense_Mutation | rs756509297 | c.1696G>A | p.Val566Met | p.V566M | A6NCI4 | protein_coding | tolerated(0.12) | benign(0.035) | TCGA-BG-A0M3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VWA3A | SNV | Missense_Mutation | c.2497T>G | p.Ser833Ala | p.S833A | A6NCI4 | protein_coding | tolerated(0.46) | benign(0.003) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VWA3A | SNV | Missense_Mutation | rs201654615 | c.1475G>A | p.Arg492Gln | p.R492Q | A6NCI4 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VWA3A | SNV | Missense_Mutation | c.211A>G | p.Thr71Ala | p.T71A | A6NCI4 | protein_coding | deleterious(0.02) | possibly_damaging(0.452) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
VWA3A | SNV | Missense_Mutation | novel | c.2261N>T | p.Pro754Leu | p.P754L | A6NCI4 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
VWA3A | SNV | Missense_Mutation | novel | c.2631N>T | p.Glu877Asp | p.E877D | A6NCI4 | protein_coding | tolerated(0.4) | benign(0.065) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
VWA3A | SNV | Missense_Mutation | novel | c.1450A>G | p.Arg484Gly | p.R484G | A6NCI4 | protein_coding | deleterious(0.04) | benign(0.155) | TCGA-DF-A2KY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
VWA3A | SNV | Missense_Mutation | rs774229691 | c.2045N>A | p.Arg682His | p.R682H | A6NCI4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VWA3A | SNV | Missense_Mutation | novel | c.2197N>T | p.Ala733Ser | p.A733S | A6NCI4 | protein_coding | tolerated(0.31) | benign(0.007) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
VWA3A | SNV | Missense_Mutation | novel | c.626T>C | p.Val209Ala | p.V209A | A6NCI4 | protein_coding | tolerated(0.16) | benign(0.42) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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