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Gene: VILL |
Gene summary for VILL |
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Gene information | Species | Human | Gene symbol | VILL | Gene ID | 50853 |
Gene name | villin like | |
Gene Alias | VILL | |
Cytomap | 3p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | O15195 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
50853 | VILL | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.90e-10 | 7.84e-01 | -0.1808 |
50853 | VILL | HTA11_347_2000001011 | Human | Colorectum | AD | 5.99e-08 | 3.84e-01 | -0.1954 |
50853 | VILL | HTA11_411_2000001011 | Human | Colorectum | SER | 1.95e-08 | 1.69e+00 | -0.2602 |
50853 | VILL | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.06e-05 | 8.20e-01 | -0.2196 |
50853 | VILL | HTA11_696_2000001011 | Human | Colorectum | AD | 7.85e-09 | 4.98e-01 | -0.1464 |
50853 | VILL | HTA11_866_2000001011 | Human | Colorectum | AD | 3.78e-05 | 2.89e-01 | -0.1001 |
50853 | VILL | HTA11_2992_2000001011 | Human | Colorectum | SER | 8.74e-04 | 6.84e-01 | -0.1706 |
50853 | VILL | LZE24T | Human | Esophagus | ESCC | 2.42e-13 | 3.15e-01 | 0.0596 |
50853 | VILL | P4T-E | Human | Esophagus | ESCC | 2.20e-02 | 1.08e-01 | 0.1323 |
50853 | VILL | P8T-E | Human | Esophagus | ESCC | 9.16e-09 | 1.94e-01 | 0.0889 |
50853 | VILL | P10T-E | Human | Esophagus | ESCC | 1.91e-04 | 4.02e-02 | 0.116 |
50853 | VILL | P12T-E | Human | Esophagus | ESCC | 1.07e-03 | 5.07e-02 | 0.1122 |
50853 | VILL | P16T-E | Human | Esophagus | ESCC | 3.71e-07 | 8.61e-02 | 0.1153 |
50853 | VILL | P20T-E | Human | Esophagus | ESCC | 3.11e-04 | 1.06e-01 | 0.1124 |
50853 | VILL | P21T-E | Human | Esophagus | ESCC | 2.89e-05 | 5.25e-02 | 0.1617 |
50853 | VILL | P27T-E | Human | Esophagus | ESCC | 1.83e-04 | 6.05e-02 | 0.1055 |
50853 | VILL | P28T-E | Human | Esophagus | ESCC | 2.20e-07 | 1.25e-01 | 0.1149 |
50853 | VILL | P36T-E | Human | Esophagus | ESCC | 5.72e-04 | 1.84e-01 | 0.1187 |
50853 | VILL | P39T-E | Human | Esophagus | ESCC | 3.23e-04 | 4.92e-02 | 0.0894 |
50853 | VILL | P57T-E | Human | Esophagus | ESCC | 1.03e-05 | 9.67e-02 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0032272 | Colorectum | AD | negative regulation of protein polymerization | 36/3918 | 80/18723 | 1.13e-06 | 3.72e-05 | 36 |
GO:0030837 | Colorectum | AD | negative regulation of actin filament polymerization | 30/3918 | 65/18723 | 4.59e-06 | 1.22e-04 | 30 |
GO:1902904 | Colorectum | AD | negative regulation of supramolecular fiber organization | 60/3918 | 167/18723 | 5.23e-06 | 1.35e-04 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VILL | SNV | Missense_Mutation | c.712N>G | p.Thr238Ala | p.T238A | O15195 | protein_coding | tolerated(0.4) | benign(0.001) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
VILL | SNV | Missense_Mutation | rs774021167 | c.2450N>A | p.Arg817His | p.R817H | O15195 | protein_coding | tolerated(0.29) | benign(0.009) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
VILL | SNV | Missense_Mutation | novel | c.2036G>C | p.Gly679Ala | p.G679A | O15195 | protein_coding | tolerated(0.06) | possibly_damaging(0.777) | TCGA-ZG-A9KY-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
VILL | SNV | Missense_Mutation | c.1227N>T | p.Lys409Asn | p.K409N | O15195 | protein_coding | tolerated(0.13) | benign(0.147) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VILL | SNV | Missense_Mutation | c.658N>G | p.Met220Val | p.M220V | O15195 | protein_coding | tolerated(0.05) | benign(0.044) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VILL | SNV | Missense_Mutation | rs368557605 | c.703N>T | p.Arg235Cys | p.R235C | O15195 | protein_coding | deleterious(0.05) | benign(0.009) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
VILL | SNV | Missense_Mutation | c.1271N>G | p.Tyr424Cys | p.Y424C | O15195 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
VILL | SNV | Missense_Mutation | novel | c.1924N>G | p.Ile642Val | p.I642V | O15195 | protein_coding | tolerated(1) | benign(0.003) | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
VILL | SNV | Missense_Mutation | novel | c.2407N>T | p.His803Tyr | p.H803Y | O15195 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
VILL | insertion | Frame_Shift_Ins | rs751305489 | c.815dupC | p.Leu273ThrfsTer30 | p.L273Tfs*30 | O15195 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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