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Gene: USP32 |
Gene summary for USP32 |
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Gene information | Species | Human | Gene symbol | USP32 | Gene ID | 84669 |
Gene name | ubiquitin specific peptidase 32 | |
Gene Alias | NY-REN-60 | |
Cytomap | 17q23.1-q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NFA0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84669 | USP32 | CCI_1 | Human | Cervix | CC | 7.75e-06 | 7.71e-01 | 0.528 |
84669 | USP32 | CCI_2 | Human | Cervix | CC | 2.53e-07 | 9.00e-01 | 0.5249 |
84669 | USP32 | CCI_3 | Human | Cervix | CC | 4.92e-11 | 6.58e-01 | 0.516 |
84669 | USP32 | CCII_1 | Human | Cervix | CC | 3.73e-03 | 3.38e-01 | 0.3249 |
84669 | USP32 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.24e-07 | -4.41e-01 | 0.0155 |
84669 | USP32 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.25e-04 | -3.74e-01 | 0.096 |
84669 | USP32 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.66e-06 | -3.21e-01 | 0.0674 |
84669 | USP32 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.14e-02 | -1.92e-01 | 0.3859 |
84669 | USP32 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.08e-09 | -4.04e-01 | 0.3005 |
84669 | USP32 | A002-C-010 | Human | Colorectum | FAP | 5.99e-04 | -1.83e-01 | 0.242 |
84669 | USP32 | A001-C-207 | Human | Colorectum | FAP | 4.07e-03 | -2.58e-01 | 0.1278 |
84669 | USP32 | A015-C-203 | Human | Colorectum | FAP | 4.30e-25 | -3.67e-01 | -0.1294 |
84669 | USP32 | A015-C-204 | Human | Colorectum | FAP | 4.33e-03 | -2.18e-01 | -0.0228 |
84669 | USP32 | A014-C-040 | Human | Colorectum | FAP | 1.10e-03 | -2.29e-01 | -0.1184 |
84669 | USP32 | A002-C-201 | Human | Colorectum | FAP | 2.42e-13 | -3.69e-01 | 0.0324 |
84669 | USP32 | A002-C-203 | Human | Colorectum | FAP | 6.01e-05 | -2.04e-01 | 0.2786 |
84669 | USP32 | A001-C-119 | Human | Colorectum | FAP | 1.18e-04 | -2.44e-01 | -0.1557 |
84669 | USP32 | A001-C-108 | Human | Colorectum | FAP | 8.27e-12 | -2.35e-01 | -0.0272 |
84669 | USP32 | A002-C-205 | Human | Colorectum | FAP | 4.04e-19 | -3.87e-01 | -0.1236 |
84669 | USP32 | A001-C-104 | Human | Colorectum | FAP | 8.94e-04 | -2.26e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:0070646 | Liver | NAFLD | protein modification by small protein removal | 29/1882 | 157/18723 | 9.11e-04 | 1.09e-02 | 29 |
GO:0016579 | Liver | NAFLD | protein deubiquitination | 26/1882 | 139/18723 | 1.35e-03 | 1.52e-02 | 26 |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP32 | SNV | Missense_Mutation | novel | c.2429N>T | p.Thr810Ile | p.T810I | Q8NFA0 | protein_coding | deleterious(0.01) | possibly_damaging(0.681) | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | novel | c.2428N>C | p.Thr810Pro | p.T810P | Q8NFA0 | protein_coding | deleterious(0.01) | probably_damaging(0.928) | TCGA-B5-A11V-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | rs768350949 | c.2107N>T | p.Arg703Cys | p.R703C | Q8NFA0 | protein_coding | deleterious(0) | possibly_damaging(0.737) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | novel | c.2559G>T | p.Lys853Asn | p.K853N | Q8NFA0 | protein_coding | deleterious(0) | possibly_damaging(0.532) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
USP32 | SNV | Missense_Mutation | novel | c.2542C>A | p.Pro848Thr | p.P848T | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | rs766172179 | c.413G>A | p.Gly138Asp | p.G138D | Q8NFA0 | protein_coding | tolerated(0.06) | benign(0.276) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | rs749641360 | c.1978C>T | p.Arg660Cys | p.R660C | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | rs770959871 | c.730C>T | p.Arg244Cys | p.R244C | Q8NFA0 | protein_coding | tolerated(0.07) | probably_damaging(0.987) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | c.2124T>A | p.Ser708Arg | p.S708R | Q8NFA0 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-BG-A0M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
USP32 | SNV | Missense_Mutation | novel | c.986N>T | p.Thr329Ile | p.T329I | Q8NFA0 | protein_coding | deleterious(0.03) | possibly_damaging(0.554) | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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