|
Gene: UBE3B |
Gene summary for UBE3B |
Gene summary. |
Gene information | Species | Human | Gene symbol | UBE3B | Gene ID | 89910 |
Gene name | ubiquitin protein ligase E3B | |
Gene Alias | BPIDS | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q7Z3V4 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
89910 | UBE3B | LZE5T | Human | Esophagus | ESCC | 1.75e-03 | 2.45e-01 | 0.0514 |
89910 | UBE3B | LZE20T | Human | Esophagus | ESCC | 9.51e-06 | 1.51e-01 | 0.0662 |
89910 | UBE3B | LZE24T | Human | Esophagus | ESCC | 4.12e-04 | 2.11e-01 | 0.0596 |
89910 | UBE3B | P1T-E | Human | Esophagus | ESCC | 1.70e-04 | 3.30e-01 | 0.0875 |
89910 | UBE3B | P2T-E | Human | Esophagus | ESCC | 1.98e-16 | 3.24e-01 | 0.1177 |
89910 | UBE3B | P4T-E | Human | Esophagus | ESCC | 6.87e-13 | 2.19e-01 | 0.1323 |
89910 | UBE3B | P5T-E | Human | Esophagus | ESCC | 2.60e-09 | 1.40e-01 | 0.1327 |
89910 | UBE3B | P8T-E | Human | Esophagus | ESCC | 1.96e-11 | 2.38e-01 | 0.0889 |
89910 | UBE3B | P9T-E | Human | Esophagus | ESCC | 3.53e-03 | 8.66e-02 | 0.1131 |
89910 | UBE3B | P10T-E | Human | Esophagus | ESCC | 2.54e-10 | 2.05e-01 | 0.116 |
89910 | UBE3B | P11T-E | Human | Esophagus | ESCC | 6.66e-05 | 3.67e-01 | 0.1426 |
89910 | UBE3B | P12T-E | Human | Esophagus | ESCC | 2.80e-07 | 1.57e-01 | 0.1122 |
89910 | UBE3B | P15T-E | Human | Esophagus | ESCC | 1.51e-12 | 2.96e-01 | 0.1149 |
89910 | UBE3B | P16T-E | Human | Esophagus | ESCC | 6.33e-12 | 2.26e-01 | 0.1153 |
89910 | UBE3B | P17T-E | Human | Esophagus | ESCC | 1.40e-04 | 1.71e-01 | 0.1278 |
89910 | UBE3B | P19T-E | Human | Esophagus | ESCC | 2.57e-03 | 3.10e-01 | 0.1662 |
89910 | UBE3B | P20T-E | Human | Esophagus | ESCC | 4.80e-21 | 3.12e-01 | 0.1124 |
89910 | UBE3B | P21T-E | Human | Esophagus | ESCC | 1.81e-20 | 3.92e-01 | 0.1617 |
89910 | UBE3B | P22T-E | Human | Esophagus | ESCC | 3.88e-07 | 1.71e-01 | 0.1236 |
89910 | UBE3B | P23T-E | Human | Esophagus | ESCC | 6.60e-10 | 1.72e-01 | 0.108 |
Page: 1 2 3 4 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000020917 | Esophagus | ESCC | protein polyubiquitination | 170/8552 | 236/18723 | 1.40e-16 | 1.09e-14 | 170 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:000020910 | Oral cavity | OSCC | protein polyubiquitination | 150/7305 | 236/18723 | 1.59e-14 | 9.27e-13 | 150 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBE3B | SNV | Missense_Mutation | rs144278603 | c.1126G>A | p.Glu376Lys | p.E376K | Q7Z3V4 | protein_coding | tolerated(0.06) | benign(0.049) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
UBE3B | SNV | Missense_Mutation | c.3166C>T | p.Arg1056Cys | p.R1056C | Q7Z3V4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
UBE3B | SNV | Missense_Mutation | c.353N>C | p.Val118Ala | p.V118A | Q7Z3V4 | protein_coding | tolerated(0.18) | benign(0.194) | TCGA-B5-A0K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
UBE3B | SNV | Missense_Mutation | novel | c.2659N>G | p.Arg887Gly | p.R887G | Q7Z3V4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
UBE3B | SNV | Missense_Mutation | novel | c.1373A>G | p.Gln458Arg | p.Q458R | Q7Z3V4 | protein_coding | tolerated(0.59) | benign(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
UBE3B | SNV | Missense_Mutation | novel | c.1025N>C | p.Leu342Pro | p.L342P | Q7Z3V4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBE3B | SNV | Missense_Mutation | novel | c.2344N>A | p.Leu782Met | p.L782M | Q7Z3V4 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBE3B | SNV | Missense_Mutation | novel | c.1976N>T | p.Thr659Ile | p.T659I | Q7Z3V4 | protein_coding | deleterious(0.02) | benign(0.034) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE3B | SNV | Missense_Mutation | rs758725785 | c.2989N>T | p.Arg997Cys | p.R997C | Q7Z3V4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBE3B | SNV | Missense_Mutation | c.3166N>T | p.Arg1056Cys | p.R1056C | Q7Z3V4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |