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Gene: TSC22D1 |
Gene summary for TSC22D1 |
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Gene information | Species | Human | Gene symbol | TSC22D1 | Gene ID | 8848 |
Gene name | TSC22 domain family member 1 | |
Gene Alias | Ptg-2 | |
Cytomap | 13q14.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A087X0H8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8848 | TSC22D1 | GSM4909281 | Human | Breast | IDC | 3.41e-24 | -6.10e-01 | 0.21 |
8848 | TSC22D1 | GSM4909282 | Human | Breast | IDC | 4.80e-25 | -7.68e-01 | -0.0288 |
8848 | TSC22D1 | GSM4909285 | Human | Breast | IDC | 3.99e-25 | -6.35e-01 | 0.21 |
8848 | TSC22D1 | GSM4909286 | Human | Breast | IDC | 1.05e-28 | -7.74e-01 | 0.1081 |
8848 | TSC22D1 | GSM4909287 | Human | Breast | IDC | 1.04e-17 | -6.87e-01 | 0.2057 |
8848 | TSC22D1 | GSM4909290 | Human | Breast | IDC | 8.87e-24 | -8.44e-01 | 0.2096 |
8848 | TSC22D1 | GSM4909291 | Human | Breast | IDC | 1.98e-15 | -7.90e-01 | 0.1753 |
8848 | TSC22D1 | GSM4909293 | Human | Breast | IDC | 3.02e-13 | -4.93e-01 | 0.1581 |
8848 | TSC22D1 | GSM4909294 | Human | Breast | IDC | 1.20e-15 | -6.42e-01 | 0.2022 |
8848 | TSC22D1 | GSM4909296 | Human | Breast | IDC | 1.19e-31 | -8.20e-01 | 0.1524 |
8848 | TSC22D1 | GSM4909297 | Human | Breast | IDC | 5.97e-25 | -7.27e-01 | 0.1517 |
8848 | TSC22D1 | GSM4909298 | Human | Breast | IDC | 1.97e-14 | -4.79e-01 | 0.1551 |
8848 | TSC22D1 | GSM4909301 | Human | Breast | IDC | 2.21e-41 | -9.83e-01 | 0.1577 |
8848 | TSC22D1 | GSM4909302 | Human | Breast | IDC | 3.70e-20 | -7.37e-01 | 0.1545 |
8848 | TSC22D1 | GSM4909304 | Human | Breast | IDC | 1.88e-38 | -8.99e-01 | 0.1636 |
8848 | TSC22D1 | GSM4909306 | Human | Breast | IDC | 9.77e-07 | -4.29e-01 | 0.1564 |
8848 | TSC22D1 | GSM4909307 | Human | Breast | IDC | 1.47e-34 | -9.01e-01 | 0.1569 |
8848 | TSC22D1 | GSM4909308 | Human | Breast | IDC | 9.96e-24 | -7.49e-01 | 0.158 |
8848 | TSC22D1 | GSM4909309 | Human | Breast | IDC | 9.23e-03 | -3.11e-01 | 0.0483 |
8848 | TSC22D1 | GSM4909311 | Human | Breast | IDC | 4.95e-61 | -1.04e+00 | 0.1534 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSC22D1 | SNV | Missense_Mutation | novel | c.2129N>C | p.Val710Ala | p.V710A | Q15714 | protein_coding | tolerated(1) | benign(0) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
TSC22D1 | insertion | Frame_Shift_Ins | novel | c.3183_3184insC | p.Ala1062ArgfsTer53 | p.A1062Rfs*53 | Q15714 | protein_coding | TCGA-D1-A2G0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TSC22D1 | SNV | Missense_Mutation | c.2234N>T | p.Pro745Leu | p.P745L | Q15714 | protein_coding | deleterious(0) | benign(0.05) | TCGA-DD-A11B-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TSC22D1 | SNV | Missense_Mutation | novel | c.2325G>T | p.Gln775His | p.Q775H | Q15714 | protein_coding | tolerated(0.17) | probably_damaging(0.99) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TSC22D1 | SNV | Missense_Mutation | c.736N>T | p.Ser246Cys | p.S246C | Q15714 | protein_coding | deleterious(0.02) | benign(0.224) | TCGA-44-7671-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TSC22D1 | SNV | Missense_Mutation | c.321G>C | p.Lys107Asn | p.K107N | Q15714 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-49-4514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TSC22D1 | SNV | Missense_Mutation | rs748065714 | c.1541N>T | p.Gly514Val | p.G514V | Q15714 | protein_coding | tolerated(0.06) | benign(0.048) | TCGA-50-5049-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TSC22D1 | SNV | Missense_Mutation | c.495A>T | p.Leu165Phe | p.L165F | Q15714 | protein_coding | tolerated(0.05) | benign(0.155) | TCGA-50-6592-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TSC22D1 | SNV | Missense_Mutation | c.1334N>T | p.Asn445Ile | p.N445I | Q15714 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
TSC22D1 | SNV | Missense_Mutation | c.2843N>A | p.Ala948Asp | p.A948D | Q15714 | protein_coding | tolerated(0.06) | probably_damaging(0.916) | TCGA-18-3415-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | navelbine | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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