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Gene: TRIM23 |
Gene summary for TRIM23 |
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Gene information | Species | Human | Gene symbol | TRIM23 | Gene ID | 373 |
Gene name | tripartite motif containing 23 | |
Gene Alias | ARD1 | |
Cytomap | 5q12.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P36406 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
373 | TRIM23 | LZE24T | Human | Esophagus | ESCC | 1.52e-07 | 1.16e-01 | 0.0596 |
373 | TRIM23 | LZE6T | Human | Esophagus | ESCC | 1.28e-02 | 1.12e-01 | 0.0845 |
373 | TRIM23 | P1T-E | Human | Esophagus | ESCC | 1.76e-02 | 1.19e-01 | 0.0875 |
373 | TRIM23 | P2T-E | Human | Esophagus | ESCC | 1.87e-10 | 2.13e-01 | 0.1177 |
373 | TRIM23 | P4T-E | Human | Esophagus | ESCC | 2.22e-11 | 1.09e-01 | 0.1323 |
373 | TRIM23 | P5T-E | Human | Esophagus | ESCC | 3.43e-07 | 5.00e-02 | 0.1327 |
373 | TRIM23 | P8T-E | Human | Esophagus | ESCC | 2.27e-09 | 1.20e-01 | 0.0889 |
373 | TRIM23 | P9T-E | Human | Esophagus | ESCC | 2.60e-05 | 8.82e-02 | 0.1131 |
373 | TRIM23 | P10T-E | Human | Esophagus | ESCC | 4.33e-06 | 1.03e-01 | 0.116 |
373 | TRIM23 | P12T-E | Human | Esophagus | ESCC | 8.85e-04 | 1.51e-01 | 0.1122 |
373 | TRIM23 | P15T-E | Human | Esophagus | ESCC | 4.27e-05 | 1.08e-01 | 0.1149 |
373 | TRIM23 | P16T-E | Human | Esophagus | ESCC | 1.45e-13 | 2.38e-01 | 0.1153 |
373 | TRIM23 | P20T-E | Human | Esophagus | ESCC | 5.46e-13 | 1.51e-01 | 0.1124 |
373 | TRIM23 | P21T-E | Human | Esophagus | ESCC | 2.67e-06 | 5.35e-02 | 0.1617 |
373 | TRIM23 | P22T-E | Human | Esophagus | ESCC | 4.98e-11 | 7.99e-02 | 0.1236 |
373 | TRIM23 | P23T-E | Human | Esophagus | ESCC | 3.38e-05 | 1.15e-01 | 0.108 |
373 | TRIM23 | P24T-E | Human | Esophagus | ESCC | 7.57e-05 | 3.07e-02 | 0.1287 |
373 | TRIM23 | P26T-E | Human | Esophagus | ESCC | 1.60e-18 | 1.32e-01 | 0.1276 |
373 | TRIM23 | P27T-E | Human | Esophagus | ESCC | 1.63e-03 | 6.33e-02 | 0.1055 |
373 | TRIM23 | P30T-E | Human | Esophagus | ESCC | 3.35e-10 | 1.89e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM23 | SNV | Missense_Mutation | c.839N>T | p.Thr280Ile | p.T280I | P36406 | protein_coding | deleterious(0.01) | benign(0.034) | TCGA-70-6723-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TRIM23 | SNV | Missense_Mutation | novel | c.73N>A | p.Val25Ile | p.V25I | P36406 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-85-8072-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM23 | SNV | Missense_Mutation | novel | c.1301N>T | p.Pro434Leu | p.P434L | P36406 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM23 | SNV | Missense_Mutation | novel | c.737N>T | p.Asp246Val | p.D246V | P36406 | protein_coding | tolerated(0.05) | benign(0.151) | TCGA-MT-A67D-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM23 | SNV | Missense_Mutation | novel | c.1036N>G | p.Leu346Val | p.L346V | P36406 | protein_coding | tolerated(0.2) | benign(0.076) | TCGA-P3-A5QE-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
TRIM23 | SNV | Missense_Mutation | rs772713581 | c.206N>T | p.Ala69Val | p.A69V | P36406 | protein_coding | tolerated(0.33) | benign(0.01) | TCGA-UF-A719-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM23 | SNV | Missense_Mutation | novel | c.205N>A | p.Ala69Thr | p.A69T | P36406 | protein_coding | tolerated(0.84) | benign(0.01) | TCGA-UF-A719-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM23 | SNV | Missense_Mutation | novel | c.1142N>C | p.Ile381Thr | p.I381T | P36406 | protein_coding | tolerated(0.4) | benign(0.028) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
TRIM23 | SNV | Missense_Mutation | novel | c.1163N>A | p.Pro388His | p.P388H | P36406 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIM23 | SNV | Missense_Mutation | c.1374N>C | p.Lys458Asn | p.K458N | P36406 | protein_coding | tolerated(0.43) | possibly_damaging(0.819) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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