![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TRAF7 |
Gene summary for TRAF7 |
![]() |
Gene information | Species | Human | Gene symbol | TRAF7 | Gene ID | 84231 |
Gene name | TNF receptor associated factor 7 | |
Gene Alias | CAFDADD | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000027 | UniProtAcc | B3KQY7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84231 | TRAF7 | LZE4T | Human | Esophagus | ESCC | 8.85e-16 | 4.51e-01 | 0.0811 |
84231 | TRAF7 | LZE7T | Human | Esophagus | ESCC | 1.52e-13 | 6.48e-01 | 0.0667 |
84231 | TRAF7 | LZE8T | Human | Esophagus | ESCC | 1.18e-17 | 6.92e-01 | 0.067 |
84231 | TRAF7 | LZE20T | Human | Esophagus | ESCC | 7.51e-04 | 2.16e-01 | 0.0662 |
84231 | TRAF7 | LZE22D1 | Human | Esophagus | HGIN | 2.03e-02 | 9.31e-02 | 0.0595 |
84231 | TRAF7 | LZE22T | Human | Esophagus | ESCC | 1.70e-06 | 5.04e-01 | 0.068 |
84231 | TRAF7 | LZE24T | Human | Esophagus | ESCC | 3.38e-24 | 7.55e-01 | 0.0596 |
84231 | TRAF7 | LZE21T | Human | Esophagus | ESCC | 3.74e-04 | 3.83e-01 | 0.0655 |
84231 | TRAF7 | LZE6T | Human | Esophagus | ESCC | 3.35e-03 | 4.58e-02 | 0.0845 |
84231 | TRAF7 | P1T-E | Human | Esophagus | ESCC | 1.64e-12 | 6.75e-01 | 0.0875 |
84231 | TRAF7 | P2T-E | Human | Esophagus | ESCC | 1.36e-56 | 1.06e+00 | 0.1177 |
84231 | TRAF7 | P4T-E | Human | Esophagus | ESCC | 9.82e-45 | 9.86e-01 | 0.1323 |
84231 | TRAF7 | P5T-E | Human | Esophagus | ESCC | 1.28e-19 | 5.30e-01 | 0.1327 |
84231 | TRAF7 | P8T-E | Human | Esophagus | ESCC | 1.99e-27 | 5.90e-01 | 0.0889 |
84231 | TRAF7 | P9T-E | Human | Esophagus | ESCC | 1.52e-17 | 3.90e-01 | 0.1131 |
84231 | TRAF7 | P10T-E | Human | Esophagus | ESCC | 3.62e-14 | 1.99e-01 | 0.116 |
84231 | TRAF7 | P11T-E | Human | Esophagus | ESCC | 2.83e-16 | 8.82e-01 | 0.1426 |
84231 | TRAF7 | P12T-E | Human | Esophagus | ESCC | 1.49e-40 | 8.20e-01 | 0.1122 |
84231 | TRAF7 | P15T-E | Human | Esophagus | ESCC | 1.31e-52 | 1.33e+00 | 0.1149 |
84231 | TRAF7 | P16T-E | Human | Esophagus | ESCC | 4.44e-22 | 5.22e-01 | 0.1153 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:007182627 | Esophagus | HGIN | ribonucleoprotein complex subunit organization | 84/2587 | 227/18723 | 1.34e-18 | 5.37e-16 | 84 |
GO:002261827 | Esophagus | HGIN | ribonucleoprotein complex assembly | 82/2587 | 220/18723 | 2.07e-18 | 7.36e-16 | 82 |
GO:004227326 | Esophagus | HGIN | ribosomal large subunit biogenesis | 34/2587 | 72/18723 | 8.82e-12 | 1.06e-09 | 34 |
GO:200123327 | Esophagus | HGIN | regulation of apoptotic signaling pathway | 97/2587 | 356/18723 | 1.36e-11 | 1.57e-09 | 97 |
GO:004225527 | Esophagus | HGIN | ribosome assembly | 28/2587 | 61/18723 | 1.36e-09 | 1.07e-07 | 28 |
GO:200123519 | Esophagus | HGIN | positive regulation of apoptotic signaling pathway | 41/2587 | 126/18723 | 6.06e-08 | 3.22e-06 | 41 |
GO:000002726 | Esophagus | HGIN | ribosomal large subunit assembly | 13/2587 | 27/18723 | 1.95e-05 | 5.24e-04 | 13 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:2001233111 | Esophagus | ESCC | regulation of apoptotic signaling pathway | 256/8552 | 356/18723 | 4.11e-24 | 1.04e-21 | 256 |
GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:2001235110 | Esophagus | ESCC | positive regulation of apoptotic signaling pathway | 92/8552 | 126/18723 | 3.91e-10 | 1.05e-08 | 92 |
GO:0042255111 | Esophagus | ESCC | ribosome assembly | 50/8552 | 61/18723 | 5.66e-09 | 1.17e-07 | 50 |
GO:00072197 | Esophagus | ESCC | Notch signaling pathway | 106/8552 | 172/18723 | 1.74e-05 | 1.55e-04 | 106 |
GO:0000027111 | Esophagus | ESCC | ribosomal large subunit assembly | 22/8552 | 27/18723 | 1.49e-04 | 9.92e-04 | 22 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRAF7 | SNV | Missense_Mutation | c.1072G>A | p.Ala358Thr | p.A358T | Q6Q0C0 | protein_coding | tolerated(0.4) | benign(0.011) | TCGA-CD-8531-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | epirubicin | CR | |
TRAF7 | SNV | Missense_Mutation | c.1115N>C | p.Leu372Pro | p.L372P | Q6Q0C0 | protein_coding | deleterious(0.02) | probably_damaging(0.962) | TCGA-CD-A4MJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRAF7 | SNV | Missense_Mutation | c.1606N>A | p.Gly536Ser | p.G536S | Q6Q0C0 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-CG-4465-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
TRAF7 | SNV | Missense_Mutation | c.1921C>T | p.Arg641Cys | p.R641C | Q6Q0C0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
TRAF7 | SNV | Missense_Mutation | rs745522760 | c.145N>A | p.Gly49Arg | p.G49R | Q6Q0C0 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.819) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
TRAF7 | deletion | Frame_Shift_Del | novel | c.1716_1719delNNNN | p.Cys574AlafsTer59 | p.C574Afs*59 | Q6Q0C0 | protein_coding | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TRAF7 | deletion | Frame_Shift_Del | novel | c.1665_1678delNNNNNNNNNNNNNN | p.Thr557ArgfsTer26 | p.T557Rfs*26 | Q6Q0C0 | protein_coding | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |