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Gene: TICAM1 |
Gene summary for TICAM1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TICAM1 | Gene ID | 148022 |
Gene name | toll like receptor adaptor molecule 1 | |
Gene Alias | IIAE6 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q8IUC6 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148022 | TICAM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.50e-07 | 3.84e-01 | -0.1808 |
148022 | TICAM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.13e-06 | 4.09e-01 | -0.0811 |
148022 | TICAM1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.56e-03 | 2.11e-01 | -0.1954 |
148022 | TICAM1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.40e-06 | 1.12e+00 | -0.2602 |
148022 | TICAM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.73e-02 | 8.10e-01 | -0.2196 |
148022 | TICAM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.87e-05 | 2.48e-01 | -0.1464 |
148022 | TICAM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.98e-11 | 5.02e-01 | -0.059 |
148022 | TICAM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.12e-03 | 3.03e-01 | -0.0842 |
148022 | TICAM1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.03e-07 | 3.15e-01 | 0.0674 |
148022 | TICAM1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.03e-02 | 2.55e-01 | 0.3859 |
148022 | TICAM1 | LZE4T | Human | Esophagus | ESCC | 2.68e-06 | 1.84e-01 | 0.0811 |
148022 | TICAM1 | LZE7T | Human | Esophagus | ESCC | 9.65e-07 | 2.50e-01 | 0.0667 |
148022 | TICAM1 | LZE8T | Human | Esophagus | ESCC | 5.10e-11 | 3.65e-01 | 0.067 |
148022 | TICAM1 | LZE20T | Human | Esophagus | ESCC | 3.64e-06 | 1.89e-01 | 0.0662 |
148022 | TICAM1 | LZE22T | Human | Esophagus | ESCC | 3.19e-02 | 5.83e-01 | 0.068 |
148022 | TICAM1 | LZE24T | Human | Esophagus | ESCC | 8.32e-34 | 1.13e+00 | 0.0596 |
148022 | TICAM1 | LZE21T | Human | Esophagus | ESCC | 2.04e-09 | 6.42e-01 | 0.0655 |
148022 | TICAM1 | P1T-E | Human | Esophagus | ESCC | 1.17e-05 | 9.20e-01 | 0.0875 |
148022 | TICAM1 | P2T-E | Human | Esophagus | ESCC | 5.11e-07 | 9.30e-02 | 0.1177 |
148022 | TICAM1 | P4T-E | Human | Esophagus | ESCC | 2.89e-11 | 2.70e-01 | 0.1323 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
GO:1903320 | Colorectum | AD | regulation of protein modification by small protein conjugation or removal | 86/3918 | 242/18723 | 9.43e-08 | 4.65e-06 | 86 |
GO:0051099 | Colorectum | AD | positive regulation of binding | 66/3918 | 173/18723 | 1.47e-07 | 6.64e-06 | 66 |
GO:0031396 | Colorectum | AD | regulation of protein ubiquitination | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
GO:0032092 | Colorectum | AD | positive regulation of protein binding | 33/3918 | 85/18723 | 1.22e-04 | 1.78e-03 | 33 |
GO:0006809 | Colorectum | AD | nitric oxide biosynthetic process | 30/3918 | 76/18723 | 1.72e-04 | 2.33e-03 | 30 |
GO:0043123 | Colorectum | AD | positive regulation of I-kappaB kinase/NF-kappaB signaling | 60/3918 | 186/18723 | 1.91e-04 | 2.56e-03 | 60 |
GO:0043122 | Colorectum | AD | regulation of I-kappaB kinase/NF-kappaB signaling | 76/3918 | 249/18723 | 2.17e-04 | 2.85e-03 | 76 |
GO:0046209 | Colorectum | AD | nitric oxide metabolic process | 31/3918 | 81/18723 | 2.61e-04 | 3.25e-03 | 31 |
GO:0010508 | Colorectum | AD | positive regulation of autophagy | 43/3918 | 124/18723 | 2.64e-04 | 3.27e-03 | 43 |
GO:2001057 | Colorectum | AD | reactive nitrogen species metabolic process | 31/3918 | 82/18723 | 3.37e-04 | 3.94e-03 | 31 |
GO:0007249 | Colorectum | AD | I-kappaB kinase/NF-kappaB signaling | 82/3918 | 281/18723 | 6.09e-04 | 6.40e-03 | 82 |
GO:0032481 | Colorectum | AD | positive regulation of type I interferon production | 23/3918 | 58/18723 | 8.82e-04 | 8.53e-03 | 23 |
GO:0045429 | Colorectum | AD | positive regulation of nitric oxide biosynthetic process | 17/3918 | 40/18723 | 1.66e-03 | 1.38e-02 | 17 |
GO:1904407 | Colorectum | AD | positive regulation of nitric oxide metabolic process | 17/3918 | 41/18723 | 2.29e-03 | 1.79e-02 | 17 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa05417 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa054171 | Colorectum | AD | Lipid and atherosclerosis | 73/2092 | 215/8465 | 1.31e-03 | 8.27e-03 | 5.27e-03 | 73 |
hsa051601 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa051352 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa054172 | Colorectum | SER | Lipid and atherosclerosis | 55/1580 | 215/8465 | 6.83e-03 | 3.77e-02 | 2.74e-02 | 55 |
hsa051353 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa054173 | Colorectum | SER | Lipid and atherosclerosis | 55/1580 | 215/8465 | 6.83e-03 | 3.77e-02 | 2.74e-02 | 55 |
hsa051354 | Colorectum | MSS | Yersinia infection | 53/1875 | 137/8465 | 7.73e-06 | 8.93e-05 | 5.47e-05 | 53 |
hsa054174 | Colorectum | MSS | Lipid and atherosclerosis | 70/1875 | 215/8465 | 2.38e-04 | 1.81e-03 | 1.11e-03 | 70 |
hsa051602 | Colorectum | MSS | Hepatitis C | 52/1875 | 157/8465 | 9.29e-04 | 5.58e-03 | 3.42e-03 | 52 |
hsa05167 | Colorectum | MSS | Kaposi sarcoma-associated herpesvirus infection | 60/1875 | 194/8465 | 2.59e-03 | 1.27e-02 | 7.81e-03 | 60 |
hsa05161 | Colorectum | MSS | Hepatitis B | 48/1875 | 162/8465 | 1.53e-02 | 4.93e-02 | 3.02e-02 | 48 |
hsa051355 | Colorectum | MSS | Yersinia infection | 53/1875 | 137/8465 | 7.73e-06 | 8.93e-05 | 5.47e-05 | 53 |
hsa054175 | Colorectum | MSS | Lipid and atherosclerosis | 70/1875 | 215/8465 | 2.38e-04 | 1.81e-03 | 1.11e-03 | 70 |
hsa051603 | Colorectum | MSS | Hepatitis C | 52/1875 | 157/8465 | 9.29e-04 | 5.58e-03 | 3.42e-03 | 52 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TICAM1 | deletion | Frame_Shift_Del | c.1925delC | p.Pro642HisfsTer50 | p.P642Hfs*50 | Q8IUC6 | protein_coding | TCGA-DI-A0WH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TICAM1 | deletion | Frame_Shift_Del | c.1925delN | p.Pro642HisfsTer50 | p.P642Hfs*50 | Q8IUC6 | protein_coding | TCGA-EY-A1GF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TICAM1 | deletion | Frame_Shift_Del | c.1925delN | p.Pro642HisfsTer50 | p.P642Hfs*50 | Q8IUC6 | protein_coding | TCGA-EY-A1GO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |||
TICAM1 | deletion | Frame_Shift_Del | c.1925delN | p.Pro642HisfsTer50 | p.P642Hfs*50 | Q8IUC6 | protein_coding | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TICAM1 | SNV | Missense_Mutation | c.1022C>A | p.Thr341Asn | p.T341N | Q8IUC6 | protein_coding | tolerated(0.12) | benign(0.003) | TCGA-BC-A5W4-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
TICAM1 | SNV | Missense_Mutation | c.360A>C | p.Glu120Asp | p.E120D | Q8IUC6 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-DD-A4NI-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TICAM1 | SNV | Missense_Mutation | rs377447415 | c.1817N>A | p.Arg606Gln | p.R606Q | Q8IUC6 | protein_coding | tolerated(1) | benign(0) | TCGA-DD-AADP-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TICAM1 | SNV | Missense_Mutation | novel | c.1047C>G | p.Cys349Trp | p.C349W | Q8IUC6 | protein_coding | tolerated(0.18) | benign(0.297) | TCGA-44-7662-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TICAM1 | SNV | Missense_Mutation | novel | c.356N>C | p.Gln119Pro | p.Q119P | Q8IUC6 | protein_coding | deleterious(0.03) | benign(0.136) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TICAM1 | SNV | Missense_Mutation | novel | c.674N>C | p.His225Pro | p.H225P | Q8IUC6 | protein_coding | tolerated(0.26) | benign(0) | TCGA-62-8399-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
148022 | TICAM1 | TRANSCRIPTION FACTOR | VACCINE | 18217948 |
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