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Gene: TGM3 |
Gene summary for TGM3 |
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Gene information | Species | Human | Gene symbol | TGM3 | Gene ID | 7053 |
Gene name | transglutaminase 3 | |
Gene Alias | TGE | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | Q08188 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7053 | TGM3 | HCC1_Meng | Human | Liver | HCC | 2.05e-03 | 2.17e-02 | 0.0246 |
7053 | TGM3 | HCC1 | Human | Liver | HCC | 5.10e-04 | 2.31e+00 | 0.5336 |
7053 | TGM3 | HCC2 | Human | Liver | HCC | 1.60e-10 | 2.11e+00 | 0.5341 |
7053 | TGM3 | S027 | Human | Liver | HCC | 2.57e-02 | 2.80e-01 | 0.2446 |
7053 | TGM3 | S028 | Human | Liver | HCC | 5.42e-05 | 2.05e-01 | 0.2503 |
7053 | TGM3 | S029 | Human | Liver | HCC | 1.06e-17 | 4.90e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TGM3 | SNV | Missense_Mutation | c.653N>T | p.Arg218Leu | p.R218L | Q08188 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-21-1082-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TGM3 | SNV | Missense_Mutation | novel | c.1623N>A | p.Met541Ile | p.M541I | Q08188 | protein_coding | tolerated(1) | benign(0) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
TGM3 | SNV | Missense_Mutation | c.239N>A | p.Ser80Asn | p.S80N | Q08188 | protein_coding | tolerated(0.35) | benign(0.013) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
TGM3 | SNV | Missense_Mutation | c.1189N>A | p.Arg397Ser | p.R397S | Q08188 | protein_coding | tolerated(0.32) | benign(0.017) | TCGA-60-2713-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemzar | SD | |
TGM3 | SNV | Missense_Mutation | novel | c.100N>G | p.Arg34Gly | p.R34G | Q08188 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-60-2725-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TGM3 | SNV | Missense_Mutation | novel | c.743N>T | p.Arg248Met | p.R248M | Q08188 | protein_coding | tolerated(0.07) | probably_damaging(0.951) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
TGM3 | SNV | Missense_Mutation | novel | c.1090G>T | p.Val364Leu | p.V364L | Q08188 | protein_coding | tolerated(0.49) | benign(0.121) | TCGA-85-8479-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TGM3 | SNV | Missense_Mutation | novel | c.1223N>G | p.Lys408Arg | p.K408R | Q08188 | protein_coding | tolerated(0.38) | benign(0) | TCGA-85-A511-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TGM3 | SNV | Missense_Mutation | c.599N>T | p.Arg200Leu | p.R200L | Q08188 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TGM3 | SNV | Missense_Mutation | rs750527679 | c.788N>A | p.Ser263Tyr | p.S263Y | Q08188 | protein_coding | deleterious(0.01) | probably_damaging(0.935) | TCGA-NC-A5HP-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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