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Gene: TGFBI |
Gene summary for TGFBI |
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Gene information | Species | Human | Gene symbol | TGFBI | Gene ID | 7045 |
Gene name | transforming growth factor beta induced | |
Gene Alias | BIGH3 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A0A0S2Z4Q2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7045 | TGFBI | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.67e-11 | 3.10e-01 | 0.0155 |
7045 | TGFBI | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.53e-28 | 1.76e+00 | -0.0811 |
7045 | TGFBI | HTA11_78_2000001011 | Human | Colorectum | AD | 3.21e-18 | 1.04e+00 | -0.1088 |
7045 | TGFBI | HTA11_696_2000001011 | Human | Colorectum | AD | 2.93e-09 | 3.35e-01 | -0.1464 |
7045 | TGFBI | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.75e-08 | 3.75e-01 | -0.059 |
7045 | TGFBI | HTA11_866_3004761011 | Human | Colorectum | AD | 3.40e-38 | 9.15e-01 | 0.096 |
7045 | TGFBI | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.84e-14 | 1.29e+00 | 0.0446 |
7045 | TGFBI | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.39e-19 | 1.08e+00 | 0.0528 |
7045 | TGFBI | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.99e-03 | 8.04e-01 | 0.0171 |
7045 | TGFBI | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.56e-07 | 5.03e-01 | 0.0338 |
7045 | TGFBI | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.36e-54 | 1.22e+00 | 0.0674 |
7045 | TGFBI | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.97e-70 | 2.89e+00 | 0.0588 |
7045 | TGFBI | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.48e-43 | 9.78e-01 | 0.294 |
7045 | TGFBI | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 8.59e-16 | 1.81e+00 | 0.3487 |
7045 | TGFBI | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.45e-11 | 5.45e-01 | 0.281 |
7045 | TGFBI | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.12e-134 | 3.11e+00 | 0.3859 |
7045 | TGFBI | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.82e-22 | 9.40e-01 | 0.2585 |
7045 | TGFBI | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.07e-87 | 1.60e+00 | 0.3005 |
7045 | TGFBI | A002-C-010 | Human | Colorectum | FAP | 3.30e-02 | 1.43e-01 | 0.242 |
7045 | TGFBI | A001-C-207 | Human | Colorectum | FAP | 1.11e-10 | 5.76e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007162 | Colorectum | SER | negative regulation of cell adhesion | 68/2897 | 303/18723 | 8.02e-04 | 1.01e-02 | 68 |
GO:00071621 | Colorectum | FAP | negative regulation of cell adhesion | 61/2622 | 303/18723 | 1.96e-03 | 1.65e-02 | 61 |
GO:0002062 | Colorectum | CRC | chondrocyte differentiation | 21/2078 | 106/18723 | 5.87e-03 | 4.33e-02 | 21 |
GO:00071622 | Colorectum | CRC | negative regulation of cell adhesion | 48/2078 | 303/18723 | 7.14e-03 | 4.96e-02 | 48 |
GO:0061448 | Endometrium | AEH | connective tissue development | 44/2100 | 252/18723 | 1.92e-03 | 1.51e-02 | 44 |
GO:00071627 | Endometrium | AEH | negative regulation of cell adhesion | 49/2100 | 303/18723 | 5.43e-03 | 3.37e-02 | 49 |
GO:000716214 | Endometrium | EEC | negative regulation of cell adhesion | 54/2168 | 303/18723 | 8.19e-04 | 7.62e-03 | 54 |
GO:00614481 | Endometrium | EEC | connective tissue development | 44/2168 | 252/18723 | 3.51e-03 | 2.36e-02 | 44 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:00512161 | Esophagus | ESCC | cartilage development | 103/8552 | 190/18723 | 1.08e-02 | 3.67e-02 | 103 |
GO:00020623 | Esophagus | ESCC | chondrocyte differentiation | 60/8552 | 106/18723 | 1.53e-02 | 4.94e-02 | 60 |
GO:00301983 | Oral cavity | OSCC | extracellular matrix organization | 146/7305 | 301/18723 | 4.67e-04 | 2.77e-03 | 146 |
GO:00452293 | Oral cavity | OSCC | external encapsulating structure organization | 147/7305 | 304/18723 | 5.30e-04 | 3.08e-03 | 147 |
GO:00430623 | Oral cavity | OSCC | extracellular structure organization | 146/7305 | 302/18723 | 5.59e-04 | 3.23e-03 | 146 |
GO:00071629 | Oral cavity | OSCC | negative regulation of cell adhesion | 145/7305 | 303/18723 | 9.95e-04 | 5.18e-03 | 145 |
GO:000716216 | Oral cavity | EOLP | negative regulation of cell adhesion | 61/2218 | 303/18723 | 2.11e-05 | 3.28e-04 | 61 |
GO:003019811 | Oral cavity | EOLP | extracellular matrix organization | 52/2218 | 301/18723 | 3.29e-03 | 1.90e-02 | 52 |
GO:004306211 | Oral cavity | EOLP | extracellular structure organization | 52/2218 | 302/18723 | 3.52e-03 | 2.01e-02 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TGFBI | SNV | Missense_Mutation | rs755263822 | c.691N>T | p.Leu231Phe | p.L231F | Q15582 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-CV-6941-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
TGFBI | SNV | Missense_Mutation | novel | c.664N>G | p.His222Asp | p.H222D | Q15582 | protein_coding | deleterious(0.03) | possibly_damaging(0.634) | TCGA-D6-A6EM-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TGFBI | SNV | Missense_Mutation | rs570927940 | c.1591N>G | p.Leu531Val | p.L531V | Q15582 | protein_coding | deleterious(0) | possibly_damaging(0.779) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TGFBI | deletion | Frame_Shift_Del | novel | c.1118_1119delNN | p.Pro373ArgfsTer8 | p.P373Rfs*8 | Q15582 | protein_coding | TCGA-CV-7235-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TGFBI | SNV | Missense_Mutation | rs373585898 | c.647N>A | p.Arg216Gln | p.R216Q | Q15582 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EJ-A8FN-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
TGFBI | SNV | Missense_Mutation | rs121909209 | c.1664N>A | p.Arg555Gln | p.R555Q | Q15582 | protein_coding | deleterious(0.03) | benign(0.206) | TCGA-BR-7723-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | PD |
TGFBI | SNV | Missense_Mutation | c.752N>G | p.Asp251Gly | p.D251G | Q15582 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TGFBI | SNV | Missense_Mutation | rs763560027 | c.1478C>T | p.Thr493Met | p.T493M | Q15582 | protein_coding | tolerated(0.1) | possibly_damaging(0.848) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
TGFBI | SNV | Missense_Mutation | rs766343295 | c.334N>A | p.Val112Ile | p.V112I | Q15582 | protein_coding | tolerated(1) | benign(0.003) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TGFBI | SNV | Missense_Mutation | c.1825N>C | p.Asn609His | p.N609H | Q15582 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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