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Gene: TEP1 |
Gene summary for TEP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TEP1 | Gene ID | 7011 |
Gene name | telomerase associated protein 1 | |
Gene Alias | TLP1 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000722 | UniProtAcc | G3V5X7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7011 | TEP1 | HCC1_Meng | Human | Liver | HCC | 5.51e-12 | 9.91e-03 | 0.0246 |
7011 | TEP1 | HCC2_Meng | Human | Liver | HCC | 3.49e-14 | 1.19e-01 | 0.0107 |
7011 | TEP1 | HCC1 | Human | Liver | HCC | 6.07e-13 | 1.25e+00 | 0.5336 |
7011 | TEP1 | HCC2 | Human | Liver | HCC | 2.99e-28 | 2.33e+00 | 0.5341 |
7011 | TEP1 | HCC5 | Human | Liver | HCC | 1.18e-16 | 9.99e-01 | 0.4932 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000072311 | Liver | HCC | telomere maintenance | 85/7958 | 131/18723 | 1.86e-07 | 3.40e-06 | 85 |
GO:000627811 | Liver | HCC | RNA-dependent DNA biosynthetic process | 50/7958 | 75/18723 | 2.02e-05 | 2.17e-04 | 50 |
GO:00718975 | Liver | HCC | DNA biosynthetic process | 99/7958 | 180/18723 | 4.66e-04 | 3.08e-03 | 99 |
GO:00322001 | Liver | HCC | telomere organization | 86/7958 | 159/18723 | 2.06e-03 | 1.04e-02 | 86 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TEP1 | SNV | Missense_Mutation | c.1664C>T | p.Ser555Leu | p.S555L | Q99973 | protein_coding | deleterious(0.03) | possibly_damaging(0.59) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TEP1 | insertion | Frame_Shift_Ins | novel | c.1518_1519insG | p.Asn507GlufsTer11 | p.N507Efs*11 | Q99973 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
TEP1 | deletion | Frame_Shift_Del | c.1174delN | p.Arg392AlafsTer22 | p.R392Afs*22 | Q99973 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TEP1 | deletion | Frame_Shift_Del | c.2661delN | p.Leu888TrpfsTer31 | p.L888Wfs*31 | Q99973 | protein_coding | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TEP1 | SNV | Missense_Mutation | rs149975035 | c.1787G>A | p.Arg596Gln | p.R596Q | Q99973 | protein_coding | tolerated(0.83) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEP1 | SNV | Missense_Mutation | novel | c.6176G>T | p.Gly2059Val | p.G2059V | Q99973 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TEP1 | SNV | Missense_Mutation | rs750864595 | c.4268G>A | p.Arg1423Gln | p.R1423Q | Q99973 | protein_coding | deleterious(0.02) | possibly_damaging(0.652) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TEP1 | SNV | Missense_Mutation | rs759642227 | c.1847G>A | p.Arg616His | p.R616H | Q99973 | protein_coding | deleterious(0.01) | possibly_damaging(0.621) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TEP1 | SNV | Missense_Mutation | novel | c.1190C>A | p.Ser397Tyr | p.S397Y | Q99973 | protein_coding | deleterious(0.02) | possibly_damaging(0.601) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TEP1 | SNV | Missense_Mutation | rs766727831 | c.6643N>A | p.Gly2215Arg | p.G2215R | Q99973 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7011 | TEP1 | NA | V934/V935 |
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