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Gene: TAF1C |
Gene summary for TAF1C |
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Gene information | Species | Human | Gene symbol | TAF1C | Gene ID | 9013 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit C | |
Gene Alias | MGC:39976 | |
Cytomap | 16q24.1 | |
Gene Type | protein-coding | GO ID | GO:0001188 | UniProtAcc | Q15572 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9013 | TAF1C | LZE4T | Human | Esophagus | ESCC | 2.73e-03 | 8.48e-02 | 0.0811 |
9013 | TAF1C | LZE7T | Human | Esophagus | ESCC | 1.49e-09 | 5.42e-01 | 0.0667 |
9013 | TAF1C | LZE8T | Human | Esophagus | ESCC | 8.33e-05 | 1.20e-01 | 0.067 |
9013 | TAF1C | LZE21D1 | Human | Esophagus | HGIN | 5.36e-04 | 3.89e-01 | 0.0632 |
9013 | TAF1C | LZE24T | Human | Esophagus | ESCC | 5.13e-09 | 1.97e-01 | 0.0596 |
9013 | TAF1C | LZE21T | Human | Esophagus | ESCC | 3.21e-03 | 1.71e-01 | 0.0655 |
9013 | TAF1C | P1T-E | Human | Esophagus | ESCC | 1.30e-11 | 4.27e-01 | 0.0875 |
9013 | TAF1C | P2T-E | Human | Esophagus | ESCC | 1.10e-03 | 9.57e-02 | 0.1177 |
9013 | TAF1C | P4T-E | Human | Esophagus | ESCC | 2.20e-03 | 1.07e-01 | 0.1323 |
9013 | TAF1C | P5T-E | Human | Esophagus | ESCC | 9.13e-04 | 5.76e-02 | 0.1327 |
9013 | TAF1C | P8T-E | Human | Esophagus | ESCC | 7.31e-19 | 2.41e-01 | 0.0889 |
9013 | TAF1C | P9T-E | Human | Esophagus | ESCC | 1.91e-05 | 6.51e-02 | 0.1131 |
9013 | TAF1C | P10T-E | Human | Esophagus | ESCC | 2.71e-09 | 1.32e-01 | 0.116 |
9013 | TAF1C | P11T-E | Human | Esophagus | ESCC | 7.53e-06 | 3.27e-01 | 0.1426 |
9013 | TAF1C | P12T-E | Human | Esophagus | ESCC | 3.48e-15 | 1.54e-01 | 0.1122 |
9013 | TAF1C | P15T-E | Human | Esophagus | ESCC | 8.31e-19 | 1.56e-01 | 0.1149 |
9013 | TAF1C | P16T-E | Human | Esophagus | ESCC | 5.05e-06 | 1.27e-01 | 0.1153 |
9013 | TAF1C | P20T-E | Human | Esophagus | ESCC | 1.95e-08 | 1.60e-01 | 0.1124 |
9013 | TAF1C | P21T-E | Human | Esophagus | ESCC | 2.25e-13 | 1.37e-01 | 0.1617 |
9013 | TAF1C | P22T-E | Human | Esophagus | ESCC | 1.99e-10 | 1.62e-01 | 0.1236 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063523 | Esophagus | HGIN | DNA-templated transcription, initiation | 30/2587 | 130/18723 | 2.86e-03 | 2.79e-02 | 30 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
GO:00708973 | Esophagus | ESCC | transcription preinitiation complex assembly | 30/8552 | 36/18723 | 3.60e-06 | 3.95e-05 | 30 |
GO:00063611 | Esophagus | ESCC | transcription initiation from RNA polymerase I promoter | 11/8552 | 13/18723 | 4.76e-03 | 1.85e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAF1C | SNV | Missense_Mutation | rs759498955 | c.1571N>T | p.Ala524Val | p.A524V | Q15572 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
TAF1C | SNV | Missense_Mutation | c.1345C>T | p.Pro449Ser | p.P449S | Q15572 | protein_coding | deleterious_low_confidence(0.02) | benign(0.005) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TAF1C | SNV | Missense_Mutation | rs377368073 | c.2245C>T | p.Arg749Trp | p.R749W | Q15572 | protein_coding | deleterious(0) | possibly_damaging(0.674) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
TAF1C | SNV | Missense_Mutation | c.84N>T | p.Met28Ile | p.M28I | Q15572 | protein_coding | tolerated(0.07) | benign(0.079) | TCGA-46-3768-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | SD | |
TAF1C | SNV | Missense_Mutation | novel | c.2101C>A | p.Pro701Thr | p.P701T | Q15572 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TAF1C | SNV | Missense_Mutation | novel | c.1744G>T | p.Gly582Cys | p.G582C | Q15572 | protein_coding | tolerated(0.18) | possibly_damaging(0.719) | TCGA-77-7465-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TAF1C | SNV | Missense_Mutation | novel | c.295G>A | p.Val99Ile | p.V99I | Q15572 | protein_coding | deleterious(0.01) | benign(0.359) | TCGA-77-8128-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
TAF1C | SNV | Missense_Mutation | novel | c.2030N>T | p.Gln677Leu | p.Q677L | Q15572 | protein_coding | tolerated(0.15) | benign(0.033) | TCGA-85-7710-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TAF1C | SNV | Missense_Mutation | novel | c.32N>G | p.Leu11Trp | p.L11W | Q15572 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-94-7033-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
TAF1C | SNV | Missense_Mutation | rs753903803 | c.298N>A | p.Val100Met | p.V100M | Q15572 | protein_coding | deleterious(0.04) | possibly_damaging(0.866) | TCGA-CR-6471-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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