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Gene: TACC1 |
Gene summary for TACC1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TACC1 | Gene ID | 6867 |
Gene name | transforming acidic coiled-coil containing protein 1 | |
Gene Alias | Ga55 | |
Cytomap | 8p11.22 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O75410 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6867 | TACC1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.86e-09 | -4.05e-01 | 0.0155 |
6867 | TACC1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.74e-03 | 5.51e-01 | -0.1088 |
6867 | TACC1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.65e-04 | 5.06e-01 | -0.1954 |
6867 | TACC1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.74e-06 | -3.65e-01 | 0.0674 |
6867 | TACC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.80e-10 | 7.00e-01 | 0.294 |
6867 | TACC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.36e-19 | 1.19e+00 | 0.281 |
6867 | TACC1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.21e-06 | -6.65e-01 | 0.2585 |
6867 | TACC1 | F007 | Human | Colorectum | FAP | 9.75e-04 | -3.67e-01 | 0.1176 |
6867 | TACC1 | A002-C-010 | Human | Colorectum | FAP | 5.28e-03 | -3.14e-01 | 0.242 |
6867 | TACC1 | A001-C-207 | Human | Colorectum | FAP | 1.44e-02 | -1.97e-01 | 0.1278 |
6867 | TACC1 | A015-C-203 | Human | Colorectum | FAP | 4.44e-25 | -3.47e-01 | -0.1294 |
6867 | TACC1 | A015-C-204 | Human | Colorectum | FAP | 3.65e-04 | -1.75e-01 | -0.0228 |
6867 | TACC1 | A014-C-040 | Human | Colorectum | FAP | 4.24e-03 | -6.82e-02 | -0.1184 |
6867 | TACC1 | A002-C-201 | Human | Colorectum | FAP | 2.83e-17 | -4.02e-01 | 0.0324 |
6867 | TACC1 | A001-C-119 | Human | Colorectum | FAP | 7.63e-06 | -3.12e-01 | -0.1557 |
6867 | TACC1 | A001-C-108 | Human | Colorectum | FAP | 3.85e-13 | -6.89e-02 | -0.0272 |
6867 | TACC1 | A002-C-205 | Human | Colorectum | FAP | 1.74e-22 | -3.90e-01 | -0.1236 |
6867 | TACC1 | A015-C-005 | Human | Colorectum | FAP | 5.62e-04 | -2.56e-01 | -0.0336 |
6867 | TACC1 | A015-C-006 | Human | Colorectum | FAP | 1.01e-14 | -3.13e-01 | -0.0994 |
6867 | TACC1 | A015-C-106 | Human | Colorectum | FAP | 4.09e-06 | 1.19e-02 | -0.0511 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:0007052 | Colorectum | AD | mitotic spindle organization | 40/3918 | 120/18723 | 1.03e-03 | 9.61e-03 | 40 |
GO:00070511 | Colorectum | MSS | spindle organization | 53/3467 | 184/18723 | 4.23e-04 | 5.19e-03 | 53 |
GO:19028501 | Colorectum | MSS | microtubule cytoskeleton organization involved in mitosis | 44/3467 | 147/18723 | 5.17e-04 | 5.98e-03 | 44 |
GO:00070521 | Colorectum | MSS | mitotic spindle organization | 36/3467 | 120/18723 | 1.52e-03 | 1.39e-02 | 36 |
GO:00070512 | Colorectum | FAP | spindle organization | 41/2622 | 184/18723 | 1.50e-03 | 1.34e-02 | 41 |
GO:0021987 | Colorectum | FAP | cerebral cortex development | 28/2622 | 114/18723 | 1.80e-03 | 1.55e-02 | 28 |
GO:0021543 | Colorectum | FAP | pallium development | 36/2622 | 169/18723 | 6.06e-03 | 3.81e-02 | 36 |
GO:0030900 | Colorectum | FAP | forebrain development | 70/2622 | 379/18723 | 8.64e-03 | 4.98e-02 | 70 |
GO:00309001 | Colorectum | CRC | forebrain development | 66/2078 | 379/18723 | 1.36e-04 | 2.57e-03 | 66 |
GO:00219871 | Colorectum | CRC | cerebral cortex development | 24/2078 | 114/18723 | 1.45e-03 | 1.57e-02 | 24 |
GO:00215431 | Colorectum | CRC | pallium development | 32/2078 | 169/18723 | 1.74e-03 | 1.79e-02 | 32 |
GO:0021537 | Colorectum | CRC | telencephalon development | 43/2078 | 248/18723 | 2.01e-03 | 2.01e-02 | 43 |
GO:00070513 | Colorectum | CRC | spindle organization | 32/2078 | 184/18723 | 6.70e-03 | 4.77e-02 | 32 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:00215436 | Esophagus | ESCC | pallium development | 94/8552 | 169/18723 | 5.79e-03 | 2.14e-02 | 94 |
GO:00070522 | Liver | Cirrhotic | mitotic spindle organization | 46/4634 | 120/18723 | 6.56e-04 | 4.98e-03 | 46 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TACC1 | SNV | Missense_Mutation | novel | c.1519G>C | p.Glu507Gln | p.E507Q | O75410 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NC-A5HO-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR |
TACC1 | SNV | Missense_Mutation | novel | c.1837G>C | p.Glu613Gln | p.E613Q | O75410 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-CQ-7071-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TACC1 | SNV | Missense_Mutation | novel | c.2117N>C | p.Lys706Thr | p.K706T | O75410 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CV-7242-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACC1 | SNV | Missense_Mutation | novel | c.1666G>A | p.Glu556Lys | p.E556K | O75410 | protein_coding | deleterious(0.05) | benign(0.062) | TCGA-CV-7248-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TACC1 | SNV | Missense_Mutation | rs757860535 | c.2083N>G | p.Tyr695Asp | p.Y695D | O75410 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HC-A631-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
TACC1 | SNV | Missense_Mutation | c.2035G>A | p.Ala679Thr | p.A679T | O75410 | protein_coding | deleterious(0) | possibly_damaging(0.844) | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR | |
TACC1 | SNV | Missense_Mutation | c.416N>A | p.Pro139His | p.P139H | O75410 | protein_coding | deleterious(0.01) | benign(0.41) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
TACC1 | SNV | Missense_Mutation | c.2388N>T | p.Glu796Asp | p.E796D | O75410 | protein_coding | deleterious(0) | probably_damaging(0.913) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
TACC1 | SNV | Missense_Mutation | rs775926435 | c.1816N>A | p.Val606Met | p.V606M | O75410 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-CG-4474-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TACC1 | SNV | Missense_Mutation | rs149836912 | c.2299C>T | p.Arg767Cys | p.R767C | O75410 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D7-5577-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | calcium foliatum | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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