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Gene: TAB3 |
Gene summary for TAB3 |
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Gene information | Species | Human | Gene symbol | TAB3 | Gene ID | 257397 |
Gene name | TGF-beta activated kinase 1 (MAP3K7) binding protein 3 | |
Gene Alias | MAP3K7IP3 | |
Cytomap | Xp21.2 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | Q8N5C8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
257397 | TAB3 | NAFLD1 | Human | Liver | NAFLD | 2.20e-04 | 4.42e-01 | -0.04 |
257397 | TAB3 | HCC1_Meng | Human | Liver | HCC | 1.53e-28 | -6.94e-02 | 0.0246 |
257397 | TAB3 | HCC2_Meng | Human | Liver | HCC | 5.63e-19 | -2.07e-02 | 0.0107 |
257397 | TAB3 | HCC2 | Human | Liver | HCC | 1.71e-02 | 3.26e+00 | 0.5341 |
257397 | TAB3 | S027 | Human | Liver | HCC | 3.90e-02 | 3.99e-01 | 0.2446 |
257397 | TAB3 | S028 | Human | Liver | HCC | 1.12e-10 | 5.29e-01 | 0.2503 |
257397 | TAB3 | S029 | Human | Liver | HCC | 3.51e-13 | 7.04e-01 | 0.2581 |
257397 | TAB3 | HTA12-26-1 | Human | Pancreas | PDAC | 1.12e-06 | 5.01e-01 | 0.3728 |
257397 | TAB3 | HTA12-29-1 | Human | Pancreas | PDAC | 4.41e-22 | 5.68e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00098957 | Liver | NAFLD | negative regulation of catabolic process | 65/1882 | 320/18723 | 2.50e-08 | 2.71e-06 | 65 |
GO:00313307 | Liver | NAFLD | negative regulation of cellular catabolic process | 55/1882 | 262/18723 | 9.35e-08 | 7.59e-06 | 55 |
GO:00105065 | Liver | NAFLD | regulation of autophagy | 57/1882 | 317/18723 | 1.00e-05 | 3.18e-04 | 57 |
GO:001050621 | Liver | HCC | regulation of autophagy | 210/7958 | 317/18723 | 7.59e-18 | 8.45e-16 | 210 |
GO:000989522 | Liver | HCC | negative regulation of catabolic process | 196/7958 | 320/18723 | 7.98e-12 | 3.35e-10 | 196 |
GO:003133022 | Liver | HCC | negative regulation of cellular catabolic process | 164/7958 | 262/18723 | 3.52e-11 | 1.35e-09 | 164 |
GO:00105074 | Liver | HCC | negative regulation of autophagy | 57/7958 | 85/18723 | 4.10e-06 | 5.27e-05 | 57 |
GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
GO:004312312 | Liver | HCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 108/7958 | 186/18723 | 1.28e-05 | 1.43e-04 | 108 |
GO:004312212 | Liver | HCC | regulation of I-kappaB kinase/NF-kappaB signaling | 138/7958 | 249/18723 | 2.47e-05 | 2.58e-04 | 138 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513214 | Liver | NAFLD | Salmonella infection | 55/1043 | 249/8465 | 8.48e-06 | 3.09e-04 | 2.49e-04 | 55 |
hsa0513014 | Liver | NAFLD | Pathogenic Escherichia coli infection | 45/1043 | 197/8465 | 2.31e-05 | 6.88e-04 | 5.54e-04 | 45 |
hsa0513114 | Liver | NAFLD | Shigellosis | 48/1043 | 247/8465 | 7.82e-04 | 1.17e-02 | 9.39e-03 | 48 |
hsa0513215 | Liver | NAFLD | Salmonella infection | 55/1043 | 249/8465 | 8.48e-06 | 3.09e-04 | 2.49e-04 | 55 |
hsa0513015 | Liver | NAFLD | Pathogenic Escherichia coli infection | 45/1043 | 197/8465 | 2.31e-05 | 6.88e-04 | 5.54e-04 | 45 |
hsa0513115 | Liver | NAFLD | Shigellosis | 48/1043 | 247/8465 | 7.82e-04 | 1.17e-02 | 9.39e-03 | 48 |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513042 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0513142 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa049362 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa046684 | Liver | HCC | TNF signaling pathway | 73/4020 | 114/8465 | 2.53e-04 | 1.19e-03 | 6.63e-04 | 73 |
hsa0513252 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513052 | Liver | HCC | Pathogenic Escherichia coli infection | 129/4020 | 197/8465 | 2.02e-07 | 2.50e-06 | 1.39e-06 | 129 |
hsa0513152 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa049363 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa0466811 | Liver | HCC | TNF signaling pathway | 73/4020 | 114/8465 | 2.53e-04 | 1.19e-03 | 6.63e-04 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAB3 | SNV | Missense_Mutation | novel | c.1921G>A | p.Ala641Thr | p.A641T | Q8N5C8 | protein_coding | tolerated(0.56) | benign(0.273) | TCGA-B5-A5OE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | SD |
TAB3 | SNV | Missense_Mutation | novel | c.1540N>C | p.Tyr514His | p.Y514H | Q8N5C8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TAB3 | SNV | Missense_Mutation | c.1613N>G | p.Glu538Gly | p.E538G | Q8N5C8 | protein_coding | deleterious(0.01) | benign(0.023) | TCGA-BS-A0UL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TAB3 | SNV | Missense_Mutation | c.1226C>T | p.Ser409Phe | p.S409F | Q8N5C8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TAB3 | SNV | Missense_Mutation | c.569A>T | p.Tyr190Phe | p.Y190F | Q8N5C8 | protein_coding | tolerated(0.8) | probably_damaging(0.998) | TCGA-BS-A0WQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TAB3 | SNV | Missense_Mutation | c.1679G>T | p.Arg560Ile | p.R560I | Q8N5C8 | protein_coding | deleterious(0) | possibly_damaging(0.888) | TCGA-D1-A0ZV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TAB3 | SNV | Missense_Mutation | c.1145N>A | p.Arg382Lys | p.R382K | Q8N5C8 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAB3 | SNV | Missense_Mutation | novel | c.204N>T | p.Arg68Ser | p.R68S | Q8N5C8 | protein_coding | deleterious(0.03) | benign(0.068) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TAB3 | SNV | Missense_Mutation | c.2108G>A | p.Cys703Tyr | p.C703Y | Q8N5C8 | protein_coding | deleterious(0) | possibly_damaging(0.673) | TCGA-D1-A174-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TAB3 | SNV | Missense_Mutation | c.430N>A | p.Glu144Lys | p.E144K | Q8N5C8 | protein_coding | deleterious(0.01) | benign(0.3) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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