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Gene: SYNCRIP |
Gene summary for SYNCRIP |
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Gene information | Species | Human | Gene symbol | SYNCRIP | Gene ID | 10492 |
Gene name | synaptotagmin binding cytoplasmic RNA interacting protein | |
Gene Alias | GRY-RBP | |
Cytomap | 6q14.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | B7Z645 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10492 | SYNCRIP | LZE2T | Human | Esophagus | ESCC | 3.07e-03 | 1.08e+00 | 0.082 |
10492 | SYNCRIP | LZE4T | Human | Esophagus | ESCC | 6.94e-05 | 5.91e-01 | 0.0811 |
10492 | SYNCRIP | LZE7T | Human | Esophagus | ESCC | 7.01e-04 | 7.96e-01 | 0.0667 |
10492 | SYNCRIP | LZE20T | Human | Esophagus | ESCC | 1.99e-03 | -1.44e-01 | 0.0662 |
10492 | SYNCRIP | LZE22D1 | Human | Esophagus | HGIN | 1.63e-02 | -3.33e-01 | 0.0595 |
10492 | SYNCRIP | LZE24T | Human | Esophagus | ESCC | 6.49e-07 | 4.37e-01 | 0.0596 |
10492 | SYNCRIP | P1T-E | Human | Esophagus | ESCC | 5.18e-05 | 6.13e-01 | 0.0875 |
10492 | SYNCRIP | P2T-E | Human | Esophagus | ESCC | 7.64e-48 | 1.27e+00 | 0.1177 |
10492 | SYNCRIP | P4T-E | Human | Esophagus | ESCC | 7.90e-45 | 1.68e+00 | 0.1323 |
10492 | SYNCRIP | P5T-E | Human | Esophagus | ESCC | 7.33e-34 | 1.05e+00 | 0.1327 |
10492 | SYNCRIP | P8T-E | Human | Esophagus | ESCC | 7.73e-24 | 7.89e-01 | 0.0889 |
10492 | SYNCRIP | P9T-E | Human | Esophagus | ESCC | 1.16e-14 | 5.88e-01 | 0.1131 |
10492 | SYNCRIP | P10T-E | Human | Esophagus | ESCC | 8.72e-37 | 1.02e+00 | 0.116 |
10492 | SYNCRIP | P11T-E | Human | Esophagus | ESCC | 1.57e-06 | 6.66e-01 | 0.1426 |
10492 | SYNCRIP | P12T-E | Human | Esophagus | ESCC | 1.54e-34 | 1.01e+00 | 0.1122 |
10492 | SYNCRIP | P15T-E | Human | Esophagus | ESCC | 9.81e-22 | 9.81e-01 | 0.1149 |
10492 | SYNCRIP | P16T-E | Human | Esophagus | ESCC | 2.38e-46 | 1.38e+00 | 0.1153 |
10492 | SYNCRIP | P17T-E | Human | Esophagus | ESCC | 1.26e-04 | 5.53e-01 | 0.1278 |
10492 | SYNCRIP | P19T-E | Human | Esophagus | ESCC | 6.83e-03 | 1.05e+00 | 0.1662 |
10492 | SYNCRIP | P20T-E | Human | Esophagus | ESCC | 1.17e-21 | 7.87e-01 | 0.1124 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000641727 | Esophagus | HGIN | regulation of translation | 139/2587 | 468/18723 | 1.46e-19 | 7.98e-17 | 139 |
GO:190331120 | Esophagus | HGIN | regulation of mRNA metabolic process | 91/2587 | 288/18723 | 5.06e-15 | 9.78e-13 | 91 |
GO:000989520 | Esophagus | HGIN | negative regulation of catabolic process | 87/2587 | 320/18723 | 1.74e-10 | 1.68e-08 | 87 |
GO:003133026 | Esophagus | HGIN | negative regulation of cellular catabolic process | 74/2587 | 262/18723 | 6.27e-10 | 5.30e-08 | 74 |
GO:000640120 | Esophagus | HGIN | RNA catabolic process | 77/2587 | 278/18723 | 7.63e-10 | 6.36e-08 | 77 |
GO:000640220 | Esophagus | HGIN | mRNA catabolic process | 67/2587 | 232/18723 | 1.47e-09 | 1.13e-07 | 67 |
GO:003465519 | Esophagus | HGIN | nucleobase-containing compound catabolic process | 98/2587 | 407/18723 | 1.44e-08 | 8.94e-07 | 98 |
GO:004670017 | Esophagus | HGIN | heterocycle catabolic process | 103/2587 | 445/18723 | 5.44e-08 | 2.99e-06 | 103 |
GO:004427018 | Esophagus | HGIN | cellular nitrogen compound catabolic process | 103/2587 | 451/18723 | 1.10e-07 | 5.56e-06 | 103 |
GO:001943917 | Esophagus | HGIN | aromatic compound catabolic process | 105/2587 | 467/18723 | 1.89e-07 | 9.31e-06 | 105 |
GO:190136117 | Esophagus | HGIN | organic cyclic compound catabolic process | 106/2587 | 495/18723 | 1.94e-06 | 7.13e-05 | 106 |
GO:00342496 | Esophagus | HGIN | negative regulation of cellular amide metabolic process | 66/2587 | 273/18723 | 2.74e-06 | 9.60e-05 | 66 |
GO:190331226 | Esophagus | HGIN | negative regulation of mRNA metabolic process | 29/2587 | 92/18723 | 1.01e-05 | 2.92e-04 | 29 |
GO:00171486 | Esophagus | HGIN | negative regulation of translation | 59/2587 | 245/18723 | 1.03e-05 | 2.96e-04 | 59 |
GO:006101318 | Esophagus | HGIN | regulation of mRNA catabolic process | 43/2587 | 166/18723 | 2.48e-05 | 6.53e-04 | 43 |
GO:000164917 | Esophagus | HGIN | osteoblast differentiation | 50/2587 | 229/18723 | 5.88e-04 | 8.30e-03 | 50 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYNCRIP | SNV | Missense_Mutation | c.1331N>C | p.Arg444Thr | p.R444T | O60506 | protein_coding | tolerated(0.39) | benign(0.161) | TCGA-49-6745-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | SD | |
SYNCRIP | SNV | Missense_Mutation | novel | c.1543G>T | p.Ala515Ser | p.A515S | O60506 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-49-AARO-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SYNCRIP | SNV | Missense_Mutation | c.1654N>A | p.Gly552Ser | p.G552S | O60506 | protein_coding | deleterious_low_confidence(0.01) | benign(0.055) | TCGA-55-8092-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SYNCRIP | SNV | Missense_Mutation | c.609A>C | p.Arg203Ser | p.R203S | O60506 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SYNCRIP | SNV | Missense_Mutation | c.1141C>G | p.Arg381Gly | p.R381G | O60506 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-75-7030-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unspecific | Cisplatin | SD | |
SYNCRIP | SNV | Missense_Mutation | novel | c.28N>A | p.Gly10Ser | p.G10S | O60506 | protein_coding | tolerated(0.25) | benign(0.23) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
SYNCRIP | SNV | Missense_Mutation | c.523N>A | p.Glu175Lys | p.E175K | O60506 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-95-7947-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SYNCRIP | SNV | Missense_Mutation | c.1433N>A | p.Arg478His | p.R478H | O60506 | protein_coding | tolerated(0.52) | probably_damaging(0.964) | TCGA-18-3421-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SYNCRIP | SNV | Missense_Mutation | c.845A>C | p.Lys282Thr | p.K282T | O60506 | protein_coding | deleterious(0) | possibly_damaging(0.643) | TCGA-21-1076-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SYNCRIP | SNV | Missense_Mutation | c.1135N>C | p.Asp379His | p.D379H | O60506 | protein_coding | deleterious(0.01) | benign(0.371) | TCGA-39-5030-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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