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Gene: SYCP2 |
Gene summary for SYCP2 |
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Gene information | Species | Human | Gene symbol | SYCP2 | Gene ID | 10388 |
Gene name | synaptonemal complex protein 2 | |
Gene Alias | SCP-2 | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9BX26 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10388 | SYCP2 | CA_HPV_2 | Human | Cervix | CC | 2.14e-13 | 3.55e-01 | 0.0391 |
10388 | SYCP2 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 6.49e-16 | 4.22e-01 | 0.0208 |
10388 | SYCP2 | CCI_1 | Human | Cervix | CC | 5.05e-10 | 7.66e-01 | 0.528 |
10388 | SYCP2 | CCI_2 | Human | Cervix | CC | 1.77e-07 | 6.24e-01 | 0.5249 |
10388 | SYCP2 | CCI_3 | Human | Cervix | CC | 1.00e-20 | 8.81e-01 | 0.516 |
10388 | SYCP2 | CCII_1 | Human | Cervix | CC | 4.87e-04 | 2.20e-01 | 0.3249 |
10388 | SYCP2 | Tumor | Human | Cervix | CC | 2.62e-11 | 2.67e-01 | 0.1241 |
10388 | SYCP2 | sample1 | Human | Cervix | CC | 2.31e-03 | 2.92e-01 | 0.0959 |
10388 | SYCP2 | sample3 | Human | Cervix | CC | 9.38e-20 | 3.74e-01 | 0.1387 |
10388 | SYCP2 | T1 | Human | Cervix | CC | 8.52e-04 | 2.33e-01 | 0.0918 |
10388 | SYCP2 | T3 | Human | Cervix | CC | 4.40e-21 | 3.82e-01 | 0.1389 |
10388 | SYCP2 | LZE7T | Human | Esophagus | ESCC | 1.95e-03 | 3.13e-01 | 0.0667 |
10388 | SYCP2 | LZE24T | Human | Esophagus | ESCC | 1.93e-05 | 1.50e-01 | 0.0596 |
10388 | SYCP2 | P2T-E | Human | Esophagus | ESCC | 8.97e-05 | 1.11e-01 | 0.1177 |
10388 | SYCP2 | P10T-E | Human | Esophagus | ESCC | 1.73e-03 | 5.90e-02 | 0.116 |
10388 | SYCP2 | P12T-E | Human | Esophagus | ESCC | 4.14e-54 | 1.07e+00 | 0.1122 |
10388 | SYCP2 | P16T-E | Human | Esophagus | ESCC | 7.04e-12 | 1.32e-01 | 0.1153 |
10388 | SYCP2 | P26T-E | Human | Esophagus | ESCC | 2.19e-02 | 1.00e-01 | 0.1276 |
10388 | SYCP2 | P36T-E | Human | Esophagus | ESCC | 1.75e-19 | 8.50e-01 | 0.1187 |
10388 | SYCP2 | P37T-E | Human | Esophagus | ESCC | 1.31e-03 | 8.68e-02 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
GO:004860813 | Cervix | HSIL_HPV | reproductive structure development | 32/737 | 424/18723 | 3.52e-04 | 5.54e-03 | 32 |
GO:006145814 | Cervix | HSIL_HPV | reproductive system development | 32/737 | 427/18723 | 3.98e-04 | 6.14e-03 | 32 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:00070592 | Oral cavity | OSCC | chromosome segregation | 206/7305 | 346/18723 | 5.82e-15 | 3.76e-13 | 206 |
GO:00482852 | Oral cavity | OSCC | organelle fission | 265/7305 | 488/18723 | 3.22e-12 | 1.27e-10 | 265 |
GO:00002801 | Oral cavity | OSCC | nuclear division | 237/7305 | 439/18723 | 9.62e-11 | 2.90e-09 | 237 |
GO:00988132 | Oral cavity | OSCC | nuclear chromosome segregation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
GO:006145817 | Oral cavity | OSCC | reproductive system development | 217/7305 | 427/18723 | 3.75e-07 | 5.63e-06 | 217 |
GO:004860816 | Oral cavity | OSCC | reproductive structure development | 214/7305 | 424/18723 | 8.58e-07 | 1.18e-05 | 214 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYCP2 | deletion | Frame_Shift_Del | novel | c.4230delN | p.Lys1410AsnfsTer10 | p.K1410Nfs*10 | Q9BX26 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SYCP2 | deletion | Frame_Shift_Del | rs753462162 | c.3071delN | p.Asn1024ThrfsTer26 | p.N1024Tfs*26 | Q9BX26 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SYCP2 | deletion | Frame_Shift_Del | rs753462162 | c.3071delN | p.Asn1024ThrfsTer26 | p.N1024Tfs*26 | Q9BX26 | protein_coding | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | ||
SYCP2 | deletion | Frame_Shift_Del | novel | c.3604delN | p.Ile1202Ter | p.I1202* | Q9BX26 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
SYCP2 | insertion | Frame_Shift_Ins | novel | c.3604dupA | p.Ile1202AsnfsTer14 | p.I1202Nfs*14 | Q9BX26 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
SYCP2 | insertion | Frame_Shift_Ins | rs755832373 | c.3948_3949insA | p.Leu1317ThrfsTer3 | p.L1317Tfs*3 | Q9BX26 | protein_coding | TCGA-G4-6625-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SYCP2 | deletion | Frame_Shift_Del | novel | c.3491delN | p.Asn1164ThrfsTer34 | p.N1164Tfs*34 | Q9BX26 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SYCP2 | insertion | Frame_Shift_Ins | novel | c.2772dupA | p.Ile925AsnfsTer12 | p.I925Nfs*12 | Q9BX26 | protein_coding | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | ||
SYCP2 | SNV | Missense_Mutation | novel | c.4454N>T | p.Ser1485Phe | p.S1485F | Q9BX26 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SYCP2 | SNV | Missense_Mutation | novel | c.1330N>T | p.Pro444Ser | p.P444S | Q9BX26 | protein_coding | tolerated(0.55) | benign(0.058) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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