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Gene: SPATA17 |
Gene summary for SPATA17 |
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Gene information | Species | Human | Gene symbol | SPATA17 | Gene ID | 128153 |
Gene name | spermatogenesis associated 17 | |
Gene Alias | CFAP305 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96L03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128153 | SPATA17 | RNA-P17T-P17T-6 | Human | Lung | IAC | 4.71e-02 | 4.64e-01 | 0.3385 |
128153 | SPATA17 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 5.60e-01 | -0.0238 |
128153 | SPATA17 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.47e-02 | 5.23e-01 | -0.0296 |
128153 | SPATA17 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.24e-04 | 5.19e-01 | -0.0263 |
128153 | SPATA17 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.06e-02 | 1.75e-01 | -0.0132 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATA17 | insertion | Frame_Shift_Ins | rs773436209 | c.86_87insA | p.Glu32GlyfsTer3 | p.E32Gfs*3 | Q96L03 | protein_coding | TCGA-85-7698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | ||
SPATA17 | SNV | Missense_Mutation | c.611C>G | p.Pro204Arg | p.P204R | Q96L03 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-CN-A63U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SPATA17 | SNV | Missense_Mutation | novel | c.120N>T | p.Gln40His | p.Q40H | Q96L03 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPATA17 | SNV | Missense_Mutation | novel | c.385N>T | p.Asp129Tyr | p.D129Y | Q96L03 | protein_coding | deleterious(0) | benign(0.438) | TCGA-CR-7379-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPATA17 | SNV | Missense_Mutation | novel | c.866A>G | p.Asp289Gly | p.D289G | Q96L03 | protein_coding | deleterious(0.02) | possibly_damaging(0.859) | TCGA-CV-6962-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPATA17 | SNV | Missense_Mutation | rs145142638 | c.760N>T | p.Arg254Cys | p.R254C | Q96L03 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
SPATA17 | SNV | Missense_Mutation | rs145142638 | c.760N>T | p.Arg254Cys | p.R254C | Q96L03 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPATA17 | SNV | Missense_Mutation | rs776077057 | c.805N>A | p.Asp269Asn | p.D269N | Q96L03 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
SPATA17 | SNV | Missense_Mutation | c.22N>A | p.Gln8Lys | p.Q8K | Q96L03 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | |
SPATA17 | SNV | Missense_Mutation | c.500A>G | p.Tyr167Cys | p.Y167C | Q96L03 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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