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Gene: SPAM1 |
Gene summary for SPAM1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SPAM1 | Gene ID | 6677 |
Gene name | sperm adhesion molecule 1 | |
Gene Alias | HEL-S-96n | |
Cytomap | 7q31.32 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P38567 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6677 | SPAM1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.93e-01 | 0.0216 |
6677 | SPAM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.59e-07 | 2.54e-01 | -0.0811 |
6677 | SPAM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.08e-06 | 3.67e-01 | -0.2196 |
6677 | SPAM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.91e-05 | 1.80e-01 | -0.1207 |
6677 | SPAM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.75e-18 | 3.51e-01 | -0.1464 |
6677 | SPAM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.36e-06 | 1.40e-01 | -0.1001 |
6677 | SPAM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.60e-11 | 2.68e-01 | -0.059 |
6677 | SPAM1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 1.89e-01 | -0.1706 |
6677 | SPAM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.16e-07 | 3.01e-01 | -0.2061 |
6677 | SPAM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.15e-01 | -0.1462 |
6677 | SPAM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.78e-03 | 1.84e-01 | -0.0842 |
6677 | SPAM1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.15e-02 | 1.58e-01 | 0.0588 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007009 | Colorectum | SER | plasma membrane organization | 36/2897 | 142/18723 | 1.50e-03 | 1.62e-02 | 36 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPAM1 | SNV | Missense_Mutation | c.919G>T | p.Val307Phe | p.V307F | P38567 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPAM1 | SNV | Missense_Mutation | c.877G>C | p.Asp293His | p.D293H | P38567 | protein_coding | tolerated(0.08) | benign(0.018) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response | |
SPAM1 | SNV | Missense_Mutation | c.922N>A | p.Phe308Ile | p.F308I | P38567 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
SPAM1 | SNV | Missense_Mutation | rs201663309 | c.434N>C | p.Ile145Thr | p.I145T | P38567 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-55-6985-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPAM1 | SNV | Missense_Mutation | c.665C>A | p.Pro222Gln | p.P222Q | P38567 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SPAM1 | SNV | Missense_Mutation | c.880N>T | p.Ala294Ser | p.A294S | P38567 | protein_coding | tolerated(0.79) | benign(0.029) | TCGA-55-8514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPAM1 | SNV | Missense_Mutation | c.694N>A | p.Pro232Thr | p.P232T | P38567 | protein_coding | tolerated(0.06) | possibly_damaging(0.656) | TCGA-55-8620-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
SPAM1 | SNV | Missense_Mutation | rs779755476 | c.172N>A | p.Glu58Lys | p.E58K | P38567 | protein_coding | deleterious(0.01) | probably_damaging(0.946) | TCGA-78-7166-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPAM1 | SNV | Missense_Mutation | rs763415181 | c.454N>A | p.Pro152Thr | p.P152T | P38567 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-8279-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
SPAM1 | SNV | Missense_Mutation | c.610A>G | p.Ile204Val | p.I204V | P38567 | protein_coding | deleterious(0) | benign(0.238) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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