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Gene: SP140L |
Gene summary for SP140L |
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Gene information | Species | Human | Gene symbol | SP140L | Gene ID | 93349 |
Gene name | SP140 nuclear body protein like | |
Gene Alias | SP140L | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | U5Y3L1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93349 | SP140L | LZE4T | Human | Esophagus | ESCC | 6.72e-17 | 3.40e-01 | 0.0811 |
93349 | SP140L | LZE5T | Human | Esophagus | ESCC | 9.01e-08 | 3.40e-01 | 0.0514 |
93349 | SP140L | LZE8T | Human | Esophagus | ESCC | 9.14e-14 | 3.18e-01 | 0.067 |
93349 | SP140L | LZE20T | Human | Esophagus | ESCC | 9.42e-13 | 3.41e-01 | 0.0662 |
93349 | SP140L | LZE22D1 | Human | Esophagus | HGIN | 1.80e-02 | 9.44e-02 | 0.0595 |
93349 | SP140L | LZE22T | Human | Esophagus | ESCC | 6.42e-06 | 3.40e-01 | 0.068 |
93349 | SP140L | LZE24T | Human | Esophagus | ESCC | 7.25e-29 | 6.05e-01 | 0.0596 |
93349 | SP140L | LZE21T | Human | Esophagus | ESCC | 1.78e-04 | 2.51e-01 | 0.0655 |
93349 | SP140L | LZE6T | Human | Esophagus | ESCC | 6.96e-10 | 3.61e-01 | 0.0845 |
93349 | SP140L | P1T-E | Human | Esophagus | ESCC | 5.28e-26 | 7.65e-01 | 0.0875 |
93349 | SP140L | P2T-E | Human | Esophagus | ESCC | 5.20e-14 | 2.57e-01 | 0.1177 |
93349 | SP140L | P4T-E | Human | Esophagus | ESCC | 7.22e-13 | 2.55e-01 | 0.1323 |
93349 | SP140L | P5T-E | Human | Esophagus | ESCC | 3.76e-02 | 9.73e-02 | 0.1327 |
93349 | SP140L | P8T-E | Human | Esophagus | ESCC | 6.48e-34 | 5.79e-01 | 0.0889 |
93349 | SP140L | P9T-E | Human | Esophagus | ESCC | 1.67e-07 | 5.21e-02 | 0.1131 |
93349 | SP140L | P11T-E | Human | Esophagus | ESCC | 5.77e-17 | 6.25e-01 | 0.1426 |
93349 | SP140L | P12T-E | Human | Esophagus | ESCC | 1.80e-14 | 3.05e-01 | 0.1122 |
93349 | SP140L | P15T-E | Human | Esophagus | ESCC | 5.69e-24 | 4.32e-01 | 0.1149 |
93349 | SP140L | P17T-E | Human | Esophagus | ESCC | 1.30e-11 | 3.66e-01 | 0.1278 |
93349 | SP140L | P19T-E | Human | Esophagus | ESCC | 3.40e-13 | 3.85e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SP140L | SNV | Missense_Mutation | novel | c.660N>T | p.Trp220Cys | p.W220C | Q9H930 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SP140L | SNV | Missense_Mutation | rs747016700 | c.1255G>A | p.Asp419Asn | p.D419N | Q9H930 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-CR-7401-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SP140L | SNV | Missense_Mutation | rs747016700 | c.1255N>A | p.Asp419Asn | p.D419N | Q9H930 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-CV-A45V-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SP140L | SNV | Missense_Mutation | novel | c.1303N>C | p.Glu435Gln | p.E435Q | Q9H930 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-P3-A6T3-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
SP140L | SNV | Missense_Mutation | c.145G>T | p.Val49Phe | p.V49F | Q9H930 | protein_coding | tolerated(1) | benign(0.003) | TCGA-EJ-5498-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | |
SP140L | SNV | Missense_Mutation | novel | c.1285N>C | p.Cys429Arg | p.C429R | Q9H930 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SP140L | SNV | Missense_Mutation | c.67N>A | p.Glu23Lys | p.E23K | Q9H930 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.916) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SP140L | SNV | Missense_Mutation | c.832N>T | p.Ala278Ser | p.A278S | Q9H930 | protein_coding | tolerated(0.35) | benign(0.026) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SP140L | SNV | Missense_Mutation | novel | c.1501N>G | p.Ile501Val | p.I501V | Q9H930 | protein_coding | tolerated(0.28) | benign(0.069) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SP140L | SNV | Missense_Mutation | c.742N>C | p.Lys248Gln | p.K248Q | Q9H930 | protein_coding | tolerated(0.1) | benign(0.271) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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