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Gene: SLCO4C1 |
Gene summary for SLCO4C1 |
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Gene information | Species | Human | Gene symbol | SLCO4C1 | Gene ID | 353189 |
Gene name | solute carrier organic anion transporter family member 4C1 | |
Gene Alias | OATP-H | |
Cytomap | 5q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q6ZQN7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
353189 | SLCO4C1 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 5.62e-03 | 3.92e-01 | -0.1408 |
353189 | SLCO4C1 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 2.30e-02 | 2.70e-01 | -0.138 |
353189 | SLCO4C1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 5.77e-24 | 1.08e+00 | -0.2116 |
353189 | SLCO4C1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.59e-06 | 8.46e-01 | -0.1941 |
353189 | SLCO4C1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.01e-07 | 1.01e+00 | -0.2107 |
353189 | SLCO4C1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.60e-21 | 1.09e+00 | -0.2119 |
353189 | SLCO4C1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.56e-02 | -1.90e-02 | -0.0132 |
353189 | SLCO4C1 | RNA-P8T2-P8T2-3 | Human | Lung | AIS | 1.80e-02 | 6.05e-01 | -0.1284 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLCO4C1 | SNV | Missense_Mutation | novel | c.1912N>G | p.Ile638Val | p.I638V | Q6ZQN7 | protein_coding | deleterious(0.01) | possibly_damaging(0.585) | TCGA-NC-A5HH-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLCO4C1 | SNV | Missense_Mutation | rs768390707 | c.619N>A | p.Asp207Asn | p.D207N | Q6ZQN7 | protein_coding | tolerated(0.32) | benign(0.006) | TCGA-CR-7402-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
SLCO4C1 | SNV | Missense_Mutation | c.998N>A | p.Ser333Tyr | p.S333Y | Q6ZQN7 | protein_coding | deleterious(0.03) | benign(0.091) | TCGA-CX-7085-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLCO4C1 | SNV | Missense_Mutation | novel | c.2053T>C | p.Phe685Leu | p.F685L | Q6ZQN7 | protein_coding | tolerated(1) | benign(0) | TCGA-CX-7086-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
SLCO4C1 | SNV | Missense_Mutation | rs370687578 | c.824N>C | p.Ile275Thr | p.I275T | Q6ZQN7 | protein_coding | deleterious(0.03) | benign(0.026) | TCGA-F7-A623-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLCO4C1 | SNV | Missense_Mutation | novel | c.1670N>T | p.Thr557Ile | p.T557I | Q6ZQN7 | protein_coding | tolerated(0.45) | benign(0.158) | TCGA-UF-A71E-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLCO4C1 | SNV | Missense_Mutation | novel | c.1162G>T | p.Val388Phe | p.V388F | Q6ZQN7 | protein_coding | deleterious(0) | benign(0.287) | TCGA-KK-A7B0-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | leuprolide | SD |
SLCO4C1 | SNV | Missense_Mutation | c.1259C>T | p.Ala420Val | p.A420V | Q6ZQN7 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-B7-5818-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLCO4C1 | SNV | Missense_Mutation | rs369272597 | c.1213T>G | p.Leu405Val | p.L405V | Q6ZQN7 | protein_coding | tolerated(0.27) | possibly_damaging(0.823) | TCGA-BR-8080-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLCO4C1 | SNV | Missense_Mutation | c.1363N>G | p.Lys455Glu | p.K455E | Q6ZQN7 | protein_coding | deleterious(0) | possibly_damaging(0.772) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
353189 | SLCO4C1 | TRANSPORTER, DRUGGABLE GENOME | 178101436 | |||
353189 | SLCO4C1 | TRANSPORTER, DRUGGABLE GENOME | Digoxin | DIGOXIN |
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