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Gene: SLC22A3 |
Gene summary for SLC22A3 |
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Gene information | Species | Human | Gene symbol | SLC22A3 | Gene ID | 6581 |
Gene name | solute carrier family 22 member 3 | |
Gene Alias | EMT | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0001504 | UniProtAcc | O75751 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6581 | SLC22A3 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.89e-05 | 8.17e-01 | -0.1406 |
6581 | SLC22A3 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 4.53e-02 | 6.45e-01 | -0.138 |
6581 | SLC22A3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 6.20e-14 | 6.65e-01 | -0.2116 |
6581 | SLC22A3 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.32e-03 | 4.71e-01 | -0.1941 |
6581 | SLC22A3 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.09e-07 | 7.10e-01 | -0.2107 |
6581 | SLC22A3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 8.45e-11 | 6.43e-01 | -0.2119 |
6581 | SLC22A3 | RNA-P3T-P3T-1 | Human | Lung | IAC | 2.11e-02 | 3.21e-01 | 0.1829 |
6581 | SLC22A3 | RNA-P3T-P3T-2 | Human | Lung | IAC | 2.78e-02 | 3.49e-01 | 0.1835 |
6581 | SLC22A3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.24e-10 | 3.41e-01 | -0.0166 |
6581 | SLC22A3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.01e-20 | 4.67e-01 | -0.0132 |
6581 | SLC22A3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 9.35e-23 | 4.18e-01 | -0.013 |
6581 | SLC22A3 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.47e-08 | 3.19e-01 | -0.0121 |
6581 | SLC22A3 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 9.16e-05 | 3.91e-01 | -0.0961 |
6581 | SLC22A3 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 2.09e-07 | 4.73e-01 | -0.0876 |
6581 | SLC22A3 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 2.03e-02 | 2.75e-01 | -0.0822 |
6581 | SLC22A3 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 4.65e-06 | 4.50e-01 | -0.0809 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00316678 | Lung | IAC | response to nutrient levels | 76/2061 | 474/18723 | 4.87e-04 | 7.08e-03 | 76 |
GO:003166713 | Lung | AIS | response to nutrient levels | 64/1849 | 474/18723 | 6.13e-03 | 4.98e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052317 | Lung | IAC | Choline metabolism in cancer | 23/1053 | 98/8465 | 1.72e-03 | 9.66e-03 | 6.41e-03 | 23 |
hsa0523112 | Lung | IAC | Choline metabolism in cancer | 23/1053 | 98/8465 | 1.72e-03 | 9.66e-03 | 6.41e-03 | 23 |
hsa0523121 | Lung | AIS | Choline metabolism in cancer | 23/961 | 98/8465 | 4.87e-04 | 4.39e-03 | 2.81e-03 | 23 |
hsa0523131 | Lung | AIS | Choline metabolism in cancer | 23/961 | 98/8465 | 4.87e-04 | 4.39e-03 | 2.81e-03 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC22A3 | SNV | Missense_Mutation | c.1154N>G | p.Ile385Ser | p.I385S | O75751 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SLC22A3 | SNV | Missense_Mutation | novel | c.1156T>C | p.Ser386Pro | p.S386P | O75751 | protein_coding | deleterious(0.01) | possibly_damaging(0.819) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
SLC22A3 | insertion | Frame_Shift_Ins | novel | c.758_759insA | p.Ile254AsnfsTer37 | p.I254Nfs*37 | O75751 | protein_coding | TCGA-BR-A4J6-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC22A3 | deletion | In_Frame_Del | novel | c.1544_1546delNNN | p.Met515_Leu516delinsIle | p.M515_L516delinsI | O75751 | protein_coding | TCGA-ET-A2N0-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6581 | SLC22A3 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSPORTER | catecholamines | 20859243 | ||
6581 | SLC22A3 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSPORTER | lamivudine | LAMIVUDINE | ||
6581 | SLC22A3 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSPORTER | ANTIDEPRESSANT DRUGS | 15121658 | ||
6581 | SLC22A3 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSPORTER | metformin | METFORMIN | 25920679,20859243,22722338 | |
6581 | SLC22A3 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSPORTER | SARCNU | SARCNU | 11783015,10632359 | |
6581 | SLC22A3 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSPORTER | inhibitor | 252827483 | DISPROCYNIUM24 |
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