![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SGSM3 |
Gene summary for SGSM3 |
![]() |
Gene information | Species | Human | Gene symbol | SGSM3 | Gene ID | 27352 |
Gene name | small G protein signaling modulator 3 | |
Gene Alias | CIP85 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006807 | UniProtAcc | B4DVE3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27352 | SGSM3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.15e-09 | 3.02e-01 | -0.1808 |
27352 | SGSM3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.30e-05 | 2.46e-01 | -0.0811 |
27352 | SGSM3 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.87e-04 | 2.26e-01 | -0.1088 |
27352 | SGSM3 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.35e-11 | 2.39e-01 | -0.1954 |
27352 | SGSM3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.73e-07 | 7.66e-01 | -0.2196 |
27352 | SGSM3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.18e-08 | 3.78e-01 | -0.1207 |
27352 | SGSM3 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.92e-06 | 3.41e-01 | -0.1526 |
27352 | SGSM3 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.03e-13 | 3.13e-01 | -0.1464 |
27352 | SGSM3 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.96e-11 | 2.21e-01 | -0.1001 |
27352 | SGSM3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.35e-12 | 3.52e-01 | -0.059 |
27352 | SGSM3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.59e-03 | 3.32e-01 | -0.1462 |
27352 | SGSM3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.84e-10 | 2.52e-01 | 0.096 |
27352 | SGSM3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.54e-03 | 3.05e-01 | 0.0446 |
27352 | SGSM3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.33e-03 | 3.85e-01 | 0.0171 |
27352 | SGSM3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.57e-07 | 2.54e-01 | 0.0338 |
27352 | SGSM3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.71e-09 | 2.11e-01 | 0.0674 |
27352 | SGSM3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.00e-06 | 2.03e-01 | 0.294 |
27352 | SGSM3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.52e-09 | 2.75e-01 | 0.3859 |
27352 | SGSM3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.57e-03 | 1.71e-01 | 0.3005 |
27352 | SGSM3 | LZE4T | Human | Esophagus | ESCC | 1.44e-03 | 4.09e-02 | 0.0811 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:0045732 | Colorectum | AD | positive regulation of protein catabolic process | 92/3918 | 231/18723 | 3.85e-11 | 4.47e-09 | 92 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:00421761 | Colorectum | SER | regulation of protein catabolic process | 126/2897 | 391/18723 | 5.33e-17 | 2.52e-14 | 126 |
GO:00457321 | Colorectum | SER | positive regulation of protein catabolic process | 77/2897 | 231/18723 | 9.91e-12 | 1.90e-09 | 77 |
GO:00098961 | Colorectum | SER | positive regulation of catabolic process | 132/2897 | 492/18723 | 4.16e-11 | 6.72e-09 | 132 |
GO:00430871 | Colorectum | SER | regulation of GTPase activity | 77/2897 | 348/18723 | 5.90e-04 | 8.07e-03 | 77 |
GO:00421762 | Colorectum | MSS | regulation of protein catabolic process | 145/3467 | 391/18723 | 2.03e-18 | 1.17e-15 | 145 |
GO:00098962 | Colorectum | MSS | positive regulation of catabolic process | 163/3467 | 492/18723 | 3.10e-15 | 9.22e-13 | 163 |
GO:00457322 | Colorectum | MSS | positive regulation of protein catabolic process | 85/3467 | 231/18723 | 3.66e-11 | 4.57e-09 | 85 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:00435471 | Colorectum | MSS | positive regulation of GTPase activity | 68/3467 | 255/18723 | 7.97e-04 | 8.38e-03 | 68 |
GO:004217627 | Esophagus | HGIN | regulation of protein catabolic process | 119/2587 | 391/18723 | 8.09e-18 | 2.43e-15 | 119 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SGSM3 | insertion | Nonsense_Mutation | novel | c.515_516insAAAA | p.Cys172Ter | p.C172* | Q96HU1 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
SGSM3 | insertion | Frame_Shift_Ins | novel | c.1908_1909insT | p.Gln637SerfsTer28 | p.Q637Sfs*28 | Q96HU1 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
27352 | SGSM3 | NA | Demecolcine | DEMECOLCINE | ||
27352 | SGSM3 | NA | RG7304 |
Page: 1 |