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Gene: SFI1 |
Gene summary for SFI1 |
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Gene information | Species | Human | Gene symbol | SFI1 | Gene ID | 9814 |
Gene name | SFI1 centrin binding protein | |
Gene Alias | PISD | |
Cytomap | 22q12.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A8K8P3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9814 | SFI1 | LZE4T | Human | Esophagus | ESCC | 1.74e-03 | 1.17e-01 | 0.0811 |
9814 | SFI1 | LZE7T | Human | Esophagus | ESCC | 4.19e-06 | 3.20e-01 | 0.0667 |
9814 | SFI1 | LZE24T | Human | Esophagus | ESCC | 3.68e-10 | 1.50e-01 | 0.0596 |
9814 | SFI1 | LZE21T | Human | Esophagus | ESCC | 3.58e-03 | 1.68e-01 | 0.0655 |
9814 | SFI1 | P1T-E | Human | Esophagus | ESCC | 1.22e-11 | 2.81e-01 | 0.0875 |
9814 | SFI1 | P2T-E | Human | Esophagus | ESCC | 2.99e-09 | 1.82e-01 | 0.1177 |
9814 | SFI1 | P4T-E | Human | Esophagus | ESCC | 1.22e-07 | 8.73e-02 | 0.1323 |
9814 | SFI1 | P8T-E | Human | Esophagus | ESCC | 2.71e-10 | 1.45e-01 | 0.0889 |
9814 | SFI1 | P9T-E | Human | Esophagus | ESCC | 1.15e-05 | 1.01e-01 | 0.1131 |
9814 | SFI1 | P10T-E | Human | Esophagus | ESCC | 6.27e-10 | 2.03e-01 | 0.116 |
9814 | SFI1 | P11T-E | Human | Esophagus | ESCC | 2.21e-02 | 1.33e-01 | 0.1426 |
9814 | SFI1 | P12T-E | Human | Esophagus | ESCC | 5.01e-04 | 1.40e-01 | 0.1122 |
9814 | SFI1 | P15T-E | Human | Esophagus | ESCC | 4.56e-04 | 9.08e-02 | 0.1149 |
9814 | SFI1 | P16T-E | Human | Esophagus | ESCC | 1.01e-03 | 1.24e-01 | 0.1153 |
9814 | SFI1 | P17T-E | Human | Esophagus | ESCC | 2.51e-04 | 1.76e-01 | 0.1278 |
9814 | SFI1 | P20T-E | Human | Esophagus | ESCC | 1.84e-02 | 8.06e-02 | 0.1124 |
9814 | SFI1 | P22T-E | Human | Esophagus | ESCC | 3.26e-09 | 1.35e-01 | 0.1236 |
9814 | SFI1 | P23T-E | Human | Esophagus | ESCC | 1.87e-05 | 1.04e-01 | 0.108 |
9814 | SFI1 | P26T-E | Human | Esophagus | ESCC | 1.45e-08 | 1.78e-01 | 0.1276 |
9814 | SFI1 | P27T-E | Human | Esophagus | ESCC | 5.78e-04 | 1.51e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SFI1 | SNV | Missense_Mutation | c.1316C>A | p.Pro439His | p.P439H | A8K8P3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CC-5262-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SFI1 | SNV | Missense_Mutation | novel | c.3221N>A | p.Pro1074Gln | p.P1074Q | A8K8P3 | protein_coding | tolerated(0.06) | benign(0.317) | TCGA-35-4123-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SFI1 | SNV | Missense_Mutation | c.2030N>C | p.Ser677Thr | p.S677T | A8K8P3 | protein_coding | tolerated(0.05) | benign(0.291) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SFI1 | SNV | Missense_Mutation | novel | c.998G>T | p.Arg333Met | p.R333M | A8K8P3 | protein_coding | deleterious(0) | possibly_damaging(0.518) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD |
SFI1 | SNV | Missense_Mutation | rs372062054 | c.2519N>T | p.Ala840Val | p.A840V | A8K8P3 | protein_coding | tolerated(0.07) | benign(0.301) | TCGA-55-8096-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SFI1 | SNV | Missense_Mutation | c.530N>C | p.Arg177Thr | p.R177T | A8K8P3 | protein_coding | tolerated(0.12) | possibly_damaging(0.461) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
SFI1 | SNV | Missense_Mutation | novel | c.1632N>G | p.Ile544Met | p.I544M | A8K8P3 | protein_coding | deleterious(0.04) | possibly_damaging(0.887) | TCGA-43-2576-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
SFI1 | SNV | Missense_Mutation | c.3032N>T | p.Arg1011Leu | p.R1011L | A8K8P3 | protein_coding | deleterious(0.01) | benign(0.138) | TCGA-43-6143-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesVaccine | recmage3-as+as15 | SD | |
SFI1 | SNV | Missense_Mutation | c.2987C>G | p.Ala996Gly | p.A996G | A8K8P3 | protein_coding | tolerated(0.09) | possibly_damaging(0.558) | TCGA-46-6025-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
SFI1 | SNV | Missense_Mutation | novel | c.2342A>T | p.His781Leu | p.H781L | A8K8P3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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