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Gene: SCLT1 |
Gene summary for SCLT1 |
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Gene information | Species | Human | Gene symbol | SCLT1 | Gene ID | 132320 |
Gene name | sodium channel and clathrin linker 1 | |
Gene Alias | CAP-1A | |
Cytomap | 4q28.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q96NL6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
132320 | SCLT1 | CCI_1 | Human | Cervix | CC | 2.39e-07 | 9.66e-01 | 0.528 |
132320 | SCLT1 | CCI_2 | Human | Cervix | CC | 6.21e-03 | 6.61e-01 | 0.5249 |
132320 | SCLT1 | CCI_3 | Human | Cervix | CC | 6.27e-17 | 1.11e+00 | 0.516 |
132320 | SCLT1 | AEH-subject1 | Human | Endometrium | AEH | 4.68e-06 | 2.65e-01 | -0.3059 |
132320 | SCLT1 | AEH-subject2 | Human | Endometrium | AEH | 4.33e-03 | 2.05e-01 | -0.2525 |
132320 | SCLT1 | AEH-subject3 | Human | Endometrium | AEH | 5.82e-07 | 2.49e-01 | -0.2576 |
132320 | SCLT1 | AEH-subject4 | Human | Endometrium | AEH | 1.92e-09 | 4.38e-01 | -0.2657 |
132320 | SCLT1 | AEH-subject5 | Human | Endometrium | AEH | 2.29e-24 | 5.50e-01 | -0.2953 |
132320 | SCLT1 | EEC-subject1 | Human | Endometrium | EEC | 1.39e-18 | 5.71e-01 | -0.2682 |
132320 | SCLT1 | EEC-subject2 | Human | Endometrium | EEC | 6.83e-04 | 2.09e-01 | -0.2607 |
132320 | SCLT1 | EEC-subject4 | Human | Endometrium | EEC | 6.26e-08 | 3.17e-01 | -0.2571 |
132320 | SCLT1 | EEC-subject5 | Human | Endometrium | EEC | 4.15e-09 | 3.15e-01 | -0.249 |
132320 | SCLT1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.40e-02 | -1.11e-02 | -0.1869 |
132320 | SCLT1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 6.34e-03 | -5.13e-02 | -0.1875 |
132320 | SCLT1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 5.56e-04 | -6.85e-02 | -0.1883 |
132320 | SCLT1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.67e-06 | -7.38e-02 | -0.1916 |
132320 | SCLT1 | LZE8T | Human | Esophagus | ESCC | 9.36e-05 | 1.86e-01 | 0.067 |
132320 | SCLT1 | LZE24T | Human | Esophagus | ESCC | 9.57e-05 | 2.00e-01 | 0.0596 |
132320 | SCLT1 | P1T-E | Human | Esophagus | ESCC | 9.46e-04 | 2.88e-01 | 0.0875 |
132320 | SCLT1 | P2T-E | Human | Esophagus | ESCC | 8.04e-29 | 5.49e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCLT1 | SNV | Missense_Mutation | novel | c.376N>A | p.Asp126Asn | p.D126N | Q96NL6 | protein_coding | tolerated(0.13) | probably_damaging(0.964) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCLT1 | SNV | Missense_Mutation | novel | c.1222T>C | p.Cys408Arg | p.C408R | Q96NL6 | protein_coding | deleterious(0) | benign(0.039) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCLT1 | SNV | Missense_Mutation | c.956N>T | p.Cys319Phe | p.C319F | Q96NL6 | protein_coding | tolerated(0.07) | benign(0.429) | TCGA-98-8023-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SCLT1 | SNV | Missense_Mutation | novel | c.796G>T | p.Ala266Ser | p.A266S | Q96NL6 | protein_coding | deleterious(0.04) | benign(0.103) | TCGA-NC-A5HN-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCLT1 | SNV | Missense_Mutation | novel | c.1582N>C | p.Glu528Gln | p.E528Q | Q96NL6 | protein_coding | deleterious(0.01) | possibly_damaging(0.836) | TCGA-CN-4740-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | erbitux | PD |
SCLT1 | SNV | Missense_Mutation | novel | c.1726N>C | p.Glu576Gln | p.E576Q | Q96NL6 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-CQ-5331-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCLT1 | SNV | Missense_Mutation | novel | c.15N>G | p.Ile5Met | p.I5M | Q96NL6 | protein_coding | tolerated(0.08) | benign(0.027) | TCGA-CV-5434-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
SCLT1 | SNV | Missense_Mutation | rs762809545 | c.1403C>T | p.Thr468Met | p.T468M | Q96NL6 | protein_coding | deleterious(0) | benign(0.255) | TCGA-UF-A7JF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
SCLT1 | SNV | Missense_Mutation | novel | c.352N>C | p.Glu118Gln | p.E118Q | Q96NL6 | protein_coding | tolerated(0.51) | benign(0.277) | TCGA-UF-A7JO-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SCLT1 | SNV | Missense_Mutation | novel | c.523C>T | p.His175Tyr | p.H175Y | Q96NL6 | protein_coding | tolerated(0.07) | benign(0.013) | TCGA-UF-A7JT-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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