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Gene: SCAP |
Gene summary for SCAP |
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Gene information | Species | Human | Gene symbol | SCAP | Gene ID | 22937 |
Gene name | SREBF chaperone | |
Gene Alias | SCAP | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0001666 | UniProtAcc | B7Z6H0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22937 | SCAP | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.87e-04 | 3.09e-01 | -0.0811 |
22937 | SCAP | HTA11_347_2000001011 | Human | Colorectum | AD | 2.32e-11 | 4.66e-01 | -0.1954 |
22937 | SCAP | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.01e-04 | 3.91e-01 | -0.059 |
22937 | SCAP | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.85e-05 | 5.47e-01 | 0.3859 |
22937 | SCAP | A002-C-010 | Human | Colorectum | FAP | 9.64e-03 | -2.57e-01 | 0.242 |
22937 | SCAP | A015-C-203 | Human | Colorectum | FAP | 3.73e-13 | -2.83e-01 | -0.1294 |
22937 | SCAP | A002-C-201 | Human | Colorectum | FAP | 2.01e-04 | -3.28e-01 | 0.0324 |
22937 | SCAP | A002-C-203 | Human | Colorectum | FAP | 3.41e-03 | -1.68e-01 | 0.2786 |
22937 | SCAP | A001-C-108 | Human | Colorectum | FAP | 3.65e-10 | -3.14e-01 | -0.0272 |
22937 | SCAP | A002-C-205 | Human | Colorectum | FAP | 1.95e-11 | -4.34e-01 | -0.1236 |
22937 | SCAP | A001-C-104 | Human | Colorectum | FAP | 2.27e-03 | -2.71e-01 | 0.0184 |
22937 | SCAP | A015-C-006 | Human | Colorectum | FAP | 6.63e-05 | -3.43e-01 | -0.0994 |
22937 | SCAP | A015-C-106 | Human | Colorectum | FAP | 3.40e-08 | -2.38e-01 | -0.0511 |
22937 | SCAP | A002-C-114 | Human | Colorectum | FAP | 1.64e-05 | -2.99e-01 | -0.1561 |
22937 | SCAP | A015-C-104 | Human | Colorectum | FAP | 1.58e-14 | -3.25e-01 | -0.1899 |
22937 | SCAP | A001-C-014 | Human | Colorectum | FAP | 2.84e-11 | -3.44e-01 | 0.0135 |
22937 | SCAP | A002-C-016 | Human | Colorectum | FAP | 1.41e-12 | -3.21e-01 | 0.0521 |
22937 | SCAP | A015-C-002 | Human | Colorectum | FAP | 3.75e-04 | -3.47e-01 | -0.0763 |
22937 | SCAP | A001-C-203 | Human | Colorectum | FAP | 9.99e-09 | -3.06e-01 | -0.0481 |
22937 | SCAP | A002-C-116 | Human | Colorectum | FAP | 2.54e-19 | -3.78e-01 | -0.0452 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0006900 | Colorectum | AD | vesicle budding from membrane | 32/3918 | 61/18723 | 5.38e-08 | 2.81e-06 | 32 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0006984 | Colorectum | AD | ER-nucleus signaling pathway | 21/3918 | 46/18723 | 1.47e-04 | 2.08e-03 | 21 |
GO:0007568 | Colorectum | AD | aging | 98/3918 | 339/18723 | 2.77e-04 | 3.39e-03 | 98 |
GO:0006888 | Colorectum | AD | endoplasmic reticulum to Golgi vesicle-mediated transport | 44/3918 | 130/18723 | 4.13e-04 | 4.68e-03 | 44 |
GO:0070482 | Colorectum | AD | response to oxygen levels | 99/3918 | 347/18723 | 4.29e-04 | 4.82e-03 | 99 |
GO:0032933 | Colorectum | AD | SREBP signaling pathway | 9/3918 | 15/18723 | 1.11e-03 | 1.01e-02 | 9 |
GO:0062012 | Colorectum | AD | regulation of small molecule metabolic process | 93/3918 | 334/18723 | 1.46e-03 | 1.24e-02 | 93 |
GO:0001666 | Colorectum | AD | response to hypoxia | 86/3918 | 307/18723 | 1.77e-03 | 1.46e-02 | 86 |
GO:0071501 | Colorectum | AD | cellular response to sterol depletion | 9/3918 | 16/18723 | 2.06e-03 | 1.64e-02 | 9 |
GO:0036293 | Colorectum | AD | response to decreased oxygen levels | 88/3918 | 322/18723 | 3.42e-03 | 2.49e-02 | 88 |
GO:0006991 | Colorectum | AD | response to sterol depletion | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:00481932 | Colorectum | MSS | Golgi vesicle transport | 101/3467 | 296/18723 | 9.09e-11 | 9.77e-09 | 101 |
GO:00069002 | Colorectum | MSS | vesicle budding from membrane | 31/3467 | 61/18723 | 1.17e-08 | 7.06e-07 | 31 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCAP | SNV | Missense_Mutation | rs747446698 | c.2819N>T | p.Pro940Leu | p.P940L | Q12770 | protein_coding | tolerated(0.36) | benign(0.009) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCAP | SNV | Missense_Mutation | novel | c.1138C>T | p.Arg380Trp | p.R380W | Q12770 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SCAP | SNV | Missense_Mutation | rs370907919 | c.551G>A | p.Arg184His | p.R184H | Q12770 | protein_coding | tolerated(0.17) | benign(0.006) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SCAP | SNV | Missense_Mutation | rs768447765 | c.346C>T | p.Arg116Cys | p.R116C | Q12770 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
SCAP | insertion | Frame_Shift_Ins | novel | c.551_552insTCATTTCTGTGTCAGTACCTGCTGGTTTCTGCTTGCAGACTTGT | p.Phe185HisfsTer54 | p.F185Hfs*54 | Q12770 | protein_coding | TCGA-AX-A06J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | ||
SCAP | SNV | Missense_Mutation | c.1741C>A | p.Pro581Thr | p.P581T | Q12770 | protein_coding | tolerated(0.06) | benign(0.03) | TCGA-LG-A6GG-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCAP | SNV | Missense_Mutation | novel | c.2692C>T | p.Arg898Trp | p.R898W | Q12770 | protein_coding | deleterious(0.01) | probably_damaging(0.965) | TCGA-ZS-A9CF-02 | Liver | NA | NA | NA | NA | NA | NA | NA |
SCAP | insertion | Frame_Shift_Ins | novel | c.1710_1711insC | p.Ser571GlnfsTer13 | p.S571Qfs*13 | Q12770 | protein_coding | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
SCAP | SNV | Missense_Mutation | c.3088N>C | p.Asp1030His | p.D1030H | Q12770 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-44-3396-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | alimta | SD | |
SCAP | SNV | Missense_Mutation | novel | c.1665G>T | p.Glu555Asp | p.E555D | Q12770 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-55-6981-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | chemo | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
22937 | SCAP | TRANSCRIPTION FACTOR | simvastatin | SIMVASTATIN | 16158080 | |
22937 | SCAP | TRANSCRIPTION FACTOR | atorvastatin | ATORVASTATIN | 18435918 |
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