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Gene: SAMD9L |
Gene summary for SAMD9L |
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Gene information | Species | Human | Gene symbol | SAMD9L | Gene ID | 219285 |
Gene name | sterile alpha motif domain containing 9 like | |
Gene Alias | ATXPC | |
Cytomap | 7q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IVG5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219285 | SAMD9L | LZE20T | Human | Esophagus | ESCC | 1.23e-07 | 4.05e-01 | 0.0662 |
219285 | SAMD9L | LZE24T | Human | Esophagus | ESCC | 3.89e-13 | 5.14e-01 | 0.0596 |
219285 | SAMD9L | LZE6T | Human | Esophagus | ESCC | 7.85e-03 | 1.84e-01 | 0.0845 |
219285 | SAMD9L | P1T-E | Human | Esophagus | ESCC | 7.11e-03 | 2.91e-01 | 0.0875 |
219285 | SAMD9L | P2T-E | Human | Esophagus | ESCC | 6.71e-22 | 4.45e-01 | 0.1177 |
219285 | SAMD9L | P5T-E | Human | Esophagus | ESCC | 2.10e-04 | 7.25e-02 | 0.1327 |
219285 | SAMD9L | P8T-E | Human | Esophagus | ESCC | 7.57e-18 | 4.06e-01 | 0.0889 |
219285 | SAMD9L | P9T-E | Human | Esophagus | ESCC | 1.16e-05 | 1.85e-01 | 0.1131 |
219285 | SAMD9L | P11T-E | Human | Esophagus | ESCC | 2.78e-10 | 5.46e-01 | 0.1426 |
219285 | SAMD9L | P20T-E | Human | Esophagus | ESCC | 1.15e-08 | 3.43e-01 | 0.1124 |
219285 | SAMD9L | P21T-E | Human | Esophagus | ESCC | 6.14e-07 | 2.19e-01 | 0.1617 |
219285 | SAMD9L | P23T-E | Human | Esophagus | ESCC | 1.07e-09 | 3.13e-01 | 0.108 |
219285 | SAMD9L | P24T-E | Human | Esophagus | ESCC | 4.29e-08 | 2.13e-01 | 0.1287 |
219285 | SAMD9L | P26T-E | Human | Esophagus | ESCC | 1.52e-02 | 9.21e-02 | 0.1276 |
219285 | SAMD9L | P27T-E | Human | Esophagus | ESCC | 3.90e-02 | 8.13e-02 | 0.1055 |
219285 | SAMD9L | P32T-E | Human | Esophagus | ESCC | 1.11e-05 | 1.54e-01 | 0.1666 |
219285 | SAMD9L | P36T-E | Human | Esophagus | ESCC | 3.06e-10 | 4.68e-01 | 0.1187 |
219285 | SAMD9L | P37T-E | Human | Esophagus | ESCC | 3.66e-06 | 2.04e-01 | 0.1371 |
219285 | SAMD9L | P40T-E | Human | Esophagus | ESCC | 5.80e-06 | 2.47e-01 | 0.109 |
219285 | SAMD9L | P47T-E | Human | Esophagus | ESCC | 2.30e-07 | 1.46e-01 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAMD9L | SNV | Missense_Mutation | novel | c.1489T>C | p.Phe497Leu | p.F497L | Q8IVG5 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | novel | c.466C>G | p.Leu156Val | p.L156V | Q8IVG5 | protein_coding | tolerated(0.44) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SAMD9L | deletion | Frame_Shift_Del | novel | c.303delG | p.Asn103IlefsTer35 | p.N103Ifs*35 | Q8IVG5 | protein_coding | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SAMD9L | insertion | Frame_Shift_Ins | novel | c.63_64insA | p.Trp22MetfsTer4 | p.W22Mfs*4 | Q8IVG5 | protein_coding | TCGA-DM-A282-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SAMD9L | SNV | Missense_Mutation | novel | c.3316G>A | p.Ala1106Thr | p.A1106T | Q8IVG5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | novel | c.2695A>C | p.Thr899Pro | p.T899P | Q8IVG5 | protein_coding | tolerated(0.16) | benign(0.367) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | c.2222A>G | p.His741Arg | p.H741R | Q8IVG5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SAMD9L | SNV | Missense_Mutation | rs778834717 | c.4568G>A | p.Arg1523His | p.R1523H | Q8IVG5 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | novel | c.4120A>C | p.Lys1374Gln | p.K1374Q | Q8IVG5 | protein_coding | tolerated(0.17) | benign(0.173) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SAMD9L | SNV | Missense_Mutation | novel | c.3039G>C | p.Leu1013Phe | p.L1013F | Q8IVG5 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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