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Gene: RPS6KA6 |
Gene summary for RPS6KA6 |
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Gene information | Species | Human | Gene symbol | RPS6KA6 | Gene ID | 27330 |
Gene name | ribosomal protein S6 kinase A6 | |
Gene Alias | PP90RSK4 | |
Cytomap | Xq21.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9UK32 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27330 | RPS6KA6 | HCC1 | Human | Liver | HCC | 2.79e-18 | 2.07e+00 | 0.5336 |
27330 | RPS6KA6 | HCC2 | Human | Liver | HCC | 1.22e-25 | 2.06e+00 | 0.5341 |
27330 | RPS6KA6 | HCC5 | Human | Liver | HCC | 1.26e-41 | 2.03e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007233122 | Liver | HCC | signal transduction by p53 class mediator | 108/7958 | 163/18723 | 7.14e-10 | 2.23e-08 | 108 |
GO:00427702 | Liver | HCC | signal transduction in response to DNA damage | 103/7958 | 172/18723 | 3.05e-06 | 4.04e-05 | 103 |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
GO:003033021 | Liver | HCC | DNA damage response, signal transduction by p53 class mediator | 46/7958 | 72/18723 | 2.02e-04 | 1.56e-03 | 46 |
GO:00434097 | Liver | HCC | negative regulation of MAPK cascade | 98/7958 | 180/18723 | 7.88e-04 | 4.74e-03 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0471422 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0493121 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa0513542 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0471432 | Liver | HCC | Thermogenesis | 170/4020 | 232/8465 | 5.36e-16 | 2.25e-14 | 1.25e-14 | 170 |
hsa0493131 | Liver | HCC | Insulin resistance | 77/4020 | 108/8465 | 3.89e-07 | 4.46e-06 | 2.48e-06 | 77 |
hsa0513552 | Liver | HCC | Yersinia infection | 92/4020 | 137/8465 | 2.25e-06 | 2.19e-05 | 1.22e-05 | 92 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS6KA6 | SNV | Missense_Mutation | c.1076G>A | p.Cys359Tyr | p.C359Y | Q9UK32 | protein_coding | tolerated(1) | benign(0) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KA6 | SNV | Missense_Mutation | novel | c.944G>A | p.Arg315Lys | p.R315K | Q9UK32 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS6KA6 | SNV | Missense_Mutation | novel | c.182T>C | p.Val61Ala | p.V61A | Q9UK32 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS6KA6 | SNV | Missense_Mutation | c.419N>G | p.Tyr140Cys | p.Y140C | Q9UK32 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KA6 | SNV | Missense_Mutation | novel | c.2177N>C | p.Val726Ala | p.V726A | Q9UK32 | protein_coding | deleterious(0) | possibly_damaging(0.7) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS6KA6 | SNV | Missense_Mutation | c.1181N>A | p.Ser394Tyr | p.S394Y | Q9UK32 | protein_coding | deleterious(0.03) | possibly_damaging(0.811) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KA6 | SNV | Missense_Mutation | c.907N>A | p.Leu303Ile | p.L303I | Q9UK32 | protein_coding | deleterious(0.03) | possibly_damaging(0.765) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KA6 | SNV | Missense_Mutation | c.833N>A | p.Arg278Lys | p.R278K | Q9UK32 | protein_coding | deleterious(0.04) | benign(0.158) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KA6 | SNV | Missense_Mutation | c.649N>G | p.Phe217Val | p.F217V | Q9UK32 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RPS6KA6 | SNV | Missense_Mutation | c.518N>G | p.Glu173Gly | p.E173G | Q9UK32 | protein_coding | deleterious(0) | benign(0.048) | TCGA-BS-A0V7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
27330 | RPS6KA6 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | inhibitor | 249565632 | AT-9283 | |
27330 | RPS6KA6 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | inhibitor | 249565718 | CHEMBL573107 | |
27330 | RPS6KA6 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | US10081632, Compound 25 | |||
27330 | RPS6KA6 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | CEP-1347 | CEP-1347 | 24044867 | |
27330 | RPS6KA6 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | inhibitor | 404859044 | ||
27330 | RPS6KA6 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | BI-D1870 | CHEMBL573107 | ||
27330 | RPS6KA6 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | inhibitor | 249565819 | ||
27330 | RPS6KA6 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | CID 138805970 |
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