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Gene: RBM27 |
Gene summary for RBM27 |
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Gene information | Species | Human | Gene symbol | RBM27 | Gene ID | 54439 |
Gene name | RNA binding motif protein 27 | |
Gene Alias | ARRS1 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9P2N5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54439 | RBM27 | HCC1_Meng | Human | Liver | HCC | 3.63e-37 | 5.74e-02 | 0.0246 |
54439 | RBM27 | HCC2_Meng | Human | Liver | HCC | 3.67e-07 | 6.59e-02 | 0.0107 |
54439 | RBM27 | HCC1 | Human | Liver | HCC | 2.45e-03 | 2.34e+00 | 0.5336 |
54439 | RBM27 | HCC2 | Human | Liver | HCC | 4.66e-21 | 3.86e+00 | 0.5341 |
54439 | RBM27 | HCC5 | Human | Liver | HCC | 1.10e-02 | 1.38e+00 | 0.4932 |
54439 | RBM27 | Pt13.a | Human | Liver | HCC | 3.73e-07 | 2.37e-01 | 0.021 |
54439 | RBM27 | Pt13.b | Human | Liver | HCC | 2.37e-21 | 3.23e-01 | 0.0251 |
54439 | RBM27 | Pt14.a | Human | Liver | HCC | 3.14e-05 | 3.90e-01 | 0.0169 |
54439 | RBM27 | Pt14.b | Human | Liver | HCC | 6.58e-10 | 3.46e-01 | 0.018 |
54439 | RBM27 | Pt14.d | Human | Liver | HCC | 5.85e-07 | 2.81e-01 | 0.0143 |
54439 | RBM27 | S016 | Human | Liver | HCC | 9.39e-05 | 1.36e-01 | 0.2243 |
54439 | RBM27 | S028 | Human | Liver | HCC | 2.68e-02 | 2.20e-01 | 0.2503 |
54439 | RBM27 | P1_S1_AK | Human | Skin | AK | 6.05e-09 | 3.95e-01 | -0.3399 |
54439 | RBM27 | P2_S3_AK | Human | Skin | AK | 3.08e-04 | 3.21e-01 | -0.3287 |
54439 | RBM27 | P4_S8_cSCC | Human | Skin | cSCC | 9.80e-16 | 3.73e-01 | -0.3095 |
54439 | RBM27 | P5_S10_cSCC | Human | Skin | cSCC | 3.48e-17 | 3.40e-01 | -0.299 |
54439 | RBM27 | P1_cSCC | Human | Skin | cSCC | 1.86e-27 | 8.05e-01 | 0.0292 |
54439 | RBM27 | P2_cSCC | Human | Skin | cSCC | 5.49e-21 | 5.58e-01 | -0.024 |
54439 | RBM27 | P4_cSCC | Human | Skin | cSCC | 1.23e-25 | 5.49e-01 | -0.00290000000000005 |
54439 | RBM27 | P10_cSCC | Human | Skin | cSCC | 8.64e-38 | 8.20e-01 | 0.1017 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM27 | SNV | Missense_Mutation | novel | c.1916N>C | p.Glu639Ala | p.E639A | Q9P2N5 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
RBM27 | SNV | Missense_Mutation | rs761695507 | c.1379N>A | p.Arg460Gln | p.R460Q | Q9P2N5 | protein_coding | tolerated_low_confidence(0.45) | possibly_damaging(0.885) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
RBM27 | SNV | Missense_Mutation | novel | c.1738N>C | p.Lys580Gln | p.K580Q | Q9P2N5 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RBM27 | SNV | Missense_Mutation | rs781385609 | c.1682N>A | p.Arg561Gln | p.R561Q | Q9P2N5 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RBM27 | insertion | Frame_Shift_Ins | novel | c.1682_1683insA | p.Arg563LysfsTer22 | p.R563Kfs*22 | Q9P2N5 | protein_coding | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | ||
RBM27 | SNV | Missense_Mutation | novel | c.1372N>T | p.Pro458Ser | p.P458S | Q9P2N5 | protein_coding | tolerated_low_confidence(0.1) | probably_damaging(0.968) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
RBM27 | SNV | Missense_Mutation | novel | c.1888N>G | p.Ile630Val | p.I630V | Q9P2N5 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-DD-AADG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
RBM27 | SNV | Missense_Mutation | novel | c.637N>G | p.Ser213Gly | p.S213G | Q9P2N5 | protein_coding | tolerated(0.58) | benign(0) | TCGA-DD-AAVY-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
RBM27 | deletion | Frame_Shift_Del | c.406delN | p.Arg138GlufsTer39 | p.R138Efs*39 | Q9P2N5 | protein_coding | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
RBM27 | SNV | Missense_Mutation | c.1865N>T | p.Ser622Ile | p.S622I | Q9P2N5 | protein_coding | deleterious(0) | possibly_damaging(0.533) | TCGA-44-A4SS-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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