|
Gene: RACGAP1 |
Gene summary for RACGAP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RACGAP1 | Gene ID | 29127 |
Gene name | Rac GTPase activating protein 1 | |
Gene Alias | CYK4 | |
Cytomap | 12q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R136 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29127 | RACGAP1 | LZE2T | Human | Esophagus | ESCC | 2.15e-04 | 5.84e-01 | 0.082 |
29127 | RACGAP1 | LZE24T | Human | Esophagus | ESCC | 1.69e-06 | 2.29e-01 | 0.0596 |
29127 | RACGAP1 | P2T-E | Human | Esophagus | ESCC | 7.39e-09 | 4.54e-01 | 0.1177 |
29127 | RACGAP1 | P4T-E | Human | Esophagus | ESCC | 1.35e-11 | 4.52e-01 | 0.1323 |
29127 | RACGAP1 | P5T-E | Human | Esophagus | ESCC | 2.29e-04 | 1.64e-01 | 0.1327 |
29127 | RACGAP1 | P8T-E | Human | Esophagus | ESCC | 4.83e-03 | 1.32e-01 | 0.0889 |
29127 | RACGAP1 | P10T-E | Human | Esophagus | ESCC | 7.95e-06 | 2.45e-01 | 0.116 |
29127 | RACGAP1 | P11T-E | Human | Esophagus | ESCC | 2.26e-04 | 2.42e-01 | 0.1426 |
29127 | RACGAP1 | P17T-E | Human | Esophagus | ESCC | 4.60e-02 | 5.61e-01 | 0.1278 |
29127 | RACGAP1 | P19T-E | Human | Esophagus | ESCC | 6.31e-05 | 5.22e-01 | 0.1662 |
29127 | RACGAP1 | P20T-E | Human | Esophagus | ESCC | 2.66e-05 | 2.50e-01 | 0.1124 |
29127 | RACGAP1 | P21T-E | Human | Esophagus | ESCC | 8.77e-05 | 2.69e-01 | 0.1617 |
29127 | RACGAP1 | P23T-E | Human | Esophagus | ESCC | 8.24e-03 | 2.12e-01 | 0.108 |
29127 | RACGAP1 | P24T-E | Human | Esophagus | ESCC | 6.36e-13 | 4.55e-01 | 0.1287 |
29127 | RACGAP1 | P26T-E | Human | Esophagus | ESCC | 3.63e-06 | 2.82e-01 | 0.1276 |
29127 | RACGAP1 | P28T-E | Human | Esophagus | ESCC | 1.67e-05 | 1.89e-01 | 0.1149 |
29127 | RACGAP1 | P30T-E | Human | Esophagus | ESCC | 7.57e-05 | 2.95e-01 | 0.137 |
29127 | RACGAP1 | P31T-E | Human | Esophagus | ESCC | 7.98e-05 | 2.22e-01 | 0.1251 |
29127 | RACGAP1 | P32T-E | Human | Esophagus | ESCC | 1.44e-08 | 3.68e-01 | 0.1666 |
29127 | RACGAP1 | P37T-E | Human | Esophagus | ESCC | 2.72e-05 | 3.02e-01 | 0.1371 |
Page: 1 2 3 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:000028115 | Esophagus | ESCC | mitotic cytokinesis | 58/8552 | 71/18723 | 4.34e-10 | 1.15e-08 | 58 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
GO:003250614 | Esophagus | ESCC | cytokinetic process | 35/8552 | 39/18723 | 9.38e-09 | 1.90e-07 | 35 |
GO:009030715 | Esophagus | ESCC | mitotic spindle assembly | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:006164015 | Esophagus | ESCC | cytoskeleton-dependent cytokinesis | 72/8552 | 100/18723 | 8.10e-08 | 1.39e-06 | 72 |
GO:00900689 | Esophagus | ESCC | positive regulation of cell cycle process | 142/8552 | 236/18723 | 4.79e-06 | 5.08e-05 | 142 |
GO:00086081 | Esophagus | ESCC | attachment of spindle microtubules to kinetochore | 29/8552 | 35/18723 | 6.61e-06 | 6.75e-05 | 29 |
GO:003086517 | Esophagus | ESCC | cortical cytoskeleton organization | 44/8552 | 61/18723 | 2.50e-05 | 2.13e-04 | 44 |
Page: 1 2 3 4 5 6 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RACGAP1 | SNV | Missense_Mutation | c.322N>G | p.Met108Val | p.M108V | Q9H0H5 | protein_coding | tolerated(1) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RACGAP1 | SNV | Missense_Mutation | c.1241A>G | p.Asp414Gly | p.D414G | Q9H0H5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
RACGAP1 | SNV | Missense_Mutation | c.1864N>A | p.Gln622Lys | p.Q622K | Q9H0H5 | protein_coding | tolerated(0.18) | possibly_damaging(0.628) | TCGA-BR-A4QI-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | PD | |
RACGAP1 | SNV | Missense_Mutation | c.959N>A | p.Arg320His | p.R320H | Q9H0H5 | protein_coding | deleterious(0.02) | benign(0.141) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
RACGAP1 | SNV | Missense_Mutation | rs765698830 | c.50N>A | p.Arg17His | p.R17H | Q9H0H5 | protein_coding | tolerated(0.37) | benign(0.05) | TCGA-RD-A8NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
RACGAP1 | SNV | Missense_Mutation | novel | c.392N>A | p.Gly131Asp | p.G131D | Q9H0H5 | protein_coding | tolerated(0.63) | benign(0.157) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
RACGAP1 | insertion | Frame_Shift_Ins | novel | c.1878_1879insT | p.Ala627CysfsTer18 | p.A627Cfs*18 | Q9H0H5 | protein_coding | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
29127 | RACGAP1 | NA | TCMDC-124522 | CHEMBL526776 | ||
29127 | RACGAP1 | NA | ISOORIENTIN | ISOORIENTIN | ||
29127 | RACGAP1 | NA | THUNBERGINOL B | THUNBERGINOL B | ||
29127 | RACGAP1 | NA | GNF-PF-321 | CHEMBL581044 | ||
29127 | RACGAP1 | NA | KAEMPFEROL | KAEMPFEROL | ||
29127 | RACGAP1 | NA | TCMDC-138263 | CHEMBL535307 | ||
29127 | RACGAP1 | NA | 4-(N,NDIMETHYLAMINO)BENZALDOXIME | CHEMBL498513 | ||
29127 | RACGAP1 | NA | COUMESTROL | COUMESTROL | ||
29127 | RACGAP1 | NA | SULFURETIN | SULFURETIN | ||
29127 | RACGAP1 | NA | NSC-60339 | CHEMBL1448793 |
Page: 1 2 3 4 5 6 7 |