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Gene: PTPRS |
Gene summary for PTPRS |
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Gene information | Species | Human | Gene symbol | PTPRS | Gene ID | 5802 |
Gene name | protein tyrosine phosphatase receptor type S | |
Gene Alias | PTPSIGMA | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q13332 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5802 | PTPRS | CCI_1 | Human | Cervix | CC | 2.34e-04 | 4.27e-01 | 0.528 |
5802 | PTPRS | CCI_3 | Human | Cervix | CC | 3.62e-12 | 6.63e-01 | 0.516 |
5802 | PTPRS | CCII_1 | Human | Cervix | CC | 4.23e-11 | 4.86e-01 | 0.3249 |
5802 | PTPRS | Tumor | Human | Cervix | CC | 2.43e-03 | 2.16e-01 | 0.1241 |
5802 | PTPRS | LZE7T | Human | Esophagus | ESCC | 2.07e-09 | 3.95e-01 | 0.0667 |
5802 | PTPRS | LZE22D1 | Human | Esophagus | HGIN | 5.14e-03 | 1.59e-01 | 0.0595 |
5802 | PTPRS | LZE24T | Human | Esophagus | ESCC | 1.09e-06 | 2.08e-01 | 0.0596 |
5802 | PTPRS | LZE21T | Human | Esophagus | ESCC | 1.57e-07 | 3.83e-01 | 0.0655 |
5802 | PTPRS | P1T-E | Human | Esophagus | ESCC | 2.65e-12 | 4.59e-01 | 0.0875 |
5802 | PTPRS | P2T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.90e-01 | 0.1177 |
5802 | PTPRS | P4T-E | Human | Esophagus | ESCC | 3.18e-14 | 2.93e-01 | 0.1323 |
5802 | PTPRS | P5T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.36e-01 | 0.1327 |
5802 | PTPRS | P8T-E | Human | Esophagus | ESCC | 2.51e-33 | 5.07e-01 | 0.0889 |
5802 | PTPRS | P9T-E | Human | Esophagus | ESCC | 1.69e-18 | 3.52e-01 | 0.1131 |
5802 | PTPRS | P10T-E | Human | Esophagus | ESCC | 2.08e-40 | 7.08e-01 | 0.116 |
5802 | PTPRS | P11T-E | Human | Esophagus | ESCC | 9.92e-21 | 6.26e-01 | 0.1426 |
5802 | PTPRS | P12T-E | Human | Esophagus | ESCC | 9.86e-34 | 6.04e-01 | 0.1122 |
5802 | PTPRS | P15T-E | Human | Esophagus | ESCC | 6.53e-23 | 4.49e-01 | 0.1149 |
5802 | PTPRS | P16T-E | Human | Esophagus | ESCC | 3.19e-23 | 3.47e-01 | 0.1153 |
5802 | PTPRS | P17T-E | Human | Esophagus | ESCC | 9.15e-12 | 3.97e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:19030349 | Cervix | CC | regulation of response to wounding | 44/2311 | 167/18723 | 6.33e-07 | 2.31e-05 | 44 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00064708 | Cervix | CC | protein dephosphorylation | 60/2311 | 281/18723 | 1.33e-05 | 2.68e-04 | 60 |
GO:00310996 | Cervix | CC | regeneration | 46/2311 | 198/18723 | 1.43e-05 | 2.84e-04 | 46 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00022212 | Cervix | CC | pattern recognition receptor signaling pathway | 39/2311 | 172/18723 | 1.08e-04 | 1.38e-03 | 39 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00622073 | Cervix | CC | regulation of pattern recognition receptor signaling pathway | 27/2311 | 105/18723 | 1.37e-04 | 1.68e-03 | 27 |
GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00609984 | Cervix | CC | regulation of dendritic spine development | 18/2311 | 61/18723 | 2.84e-04 | 3.07e-03 | 18 |
GO:19021153 | Cervix | CC | regulation of organelle assembly | 40/2311 | 186/18723 | 2.92e-04 | 3.15e-03 | 40 |
GO:000206410 | Cervix | CC | epithelial cell development | 45/2311 | 220/18723 | 4.14e-04 | 4.21e-03 | 45 |
GO:00507705 | Cervix | CC | regulation of axonogenesis | 34/2311 | 154/18723 | 4.87e-04 | 4.76e-03 | 34 |
GO:19018886 | Cervix | CC | regulation of cell junction assembly | 42/2311 | 204/18723 | 5.50e-04 | 5.29e-03 | 42 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045147 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0451412 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTPRS | deletion | Frame_Shift_Del | c.1239delN | p.Ser414AlafsTer30 | p.S414Afs*30 | Q13332 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
PTPRS | deletion | Frame_Shift_Del | c.2027delN | p.Pro676ArgfsTer134 | p.P676Rfs*134 | Q13332 | protein_coding | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PTPRS | deletion | Frame_Shift_Del | c.1233delN | p.Ser414AlafsTer30 | p.S414Afs*30 | Q13332 | protein_coding | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |||
PTPRS | deletion | Frame_Shift_Del | c.2027delN | p.Pro676ArgfsTer134 | p.P676Rfs*134 | Q13332 | protein_coding | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
PTPRS | SNV | Missense_Mutation | novel | c.4718G>T | p.Arg1573Ile | p.R1573I | Q13332 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTPRS | SNV | Missense_Mutation | novel | c.3743C>T | p.Ala1248Val | p.A1248V | Q13332 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTPRS | SNV | Missense_Mutation | rs201447856 | c.3335C>T | p.Thr1112Met | p.T1112M | Q13332 | protein_coding | tolerated(0.11) | possibly_damaging(0.454) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PTPRS | SNV | Missense_Mutation | novel | c.1076C>T | p.Pro359Leu | p.P359L | Q13332 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PTPRS | SNV | Missense_Mutation | rs770043743 | c.547C>T | p.Arg183Cys | p.R183C | Q13332 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PTPRS | SNV | Missense_Mutation | rs781304015 | c.449G>A | p.Arg150Gln | p.R150Q | Q13332 | protein_coding | deleterious(0.01) | benign(0.023) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5802 | PTPRS | DRUGGABLE GENOME, PROTEIN PHOSPHATASE, KINASE, CLINICALLY ACTIONABLE | inhibitor | 252827507 | ||
5802 | PTPRS | DRUGGABLE GENOME, PROTEIN PHOSPHATASE, KINASE, CLINICALLY ACTIONABLE | Etidronic acid | |||
5802 | PTPRS | DRUGGABLE GENOME, PROTEIN PHOSPHATASE, KINASE, CLINICALLY ACTIONABLE | inhibitor | 381118819 |
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