![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PTCH2 |
Gene summary for PTCH2 |
![]() |
Gene information | Species | Human | Gene symbol | PTCH2 | Gene ID | 8643 |
Gene name | patched 2 | |
Gene Alias | PTC2 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q9Y6C5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8643 | PTCH2 | PTC04 | Human | Thyroid | PTC | 5.67e-05 | 1.12e-01 | 0.1927 |
8643 | PTCH2 | ATC13 | Human | Thyroid | ATC | 6.42e-71 | 1.30e+00 | 0.34 |
8643 | PTCH2 | ATC5 | Human | Thyroid | ATC | 1.96e-77 | 1.36e+00 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049112 | Thyroid | PTC | cell growth | 225/5968 | 482/18723 | 4.75e-12 | 2.07e-10 | 225 |
GO:0001558111 | Thyroid | PTC | regulation of cell growth | 188/5968 | 414/18723 | 4.13e-09 | 1.09e-07 | 188 |
GO:0045879 | Thyroid | PTC | negative regulation of smoothened signaling pathway | 17/5968 | 32/18723 | 1.02e-02 | 4.11e-02 | 17 |
GO:001604927 | Thyroid | ATC | cell growth | 241/6293 | 482/18723 | 4.27e-14 | 2.35e-12 | 241 |
GO:000155826 | Thyroid | ATC | regulation of cell growth | 201/6293 | 414/18723 | 1.57e-10 | 4.76e-09 | 201 |
GO:00458791 | Thyroid | ATC | negative regulation of smoothened signaling pathway | 20/6293 | 32/18723 | 7.67e-04 | 4.24e-03 | 20 |
GO:0008589 | Thyroid | ATC | regulation of smoothened signaling pathway | 40/6293 | 81/18723 | 2.36e-03 | 1.10e-02 | 40 |
GO:0007224 | Thyroid | ATC | smoothened signaling pathway | 60/6293 | 138/18723 | 9.75e-03 | 3.57e-02 | 60 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTCH2 | SNV | Missense_Mutation | rs202184038 | c.3269C>T | p.Ala1090Val | p.A1090V | Q9Y6C5 | protein_coding | tolerated(0.51) | benign(0.012) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTCH2 | SNV | Missense_Mutation | rs753185169 | c.1307N>T | p.Ala436Val | p.A436V | Q9Y6C5 | protein_coding | deleterious(0) | possibly_damaging(0.817) | TCGA-D1-A165-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PTCH2 | SNV | Missense_Mutation | novel | c.3541N>T | p.Pro1181Ser | p.P1181S | Q9Y6C5 | protein_coding | tolerated_low_confidence(0.1) | benign(0.01) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PTCH2 | SNV | Missense_Mutation | novel | c.1655N>C | p.Leu552Pro | p.L552P | Q9Y6C5 | protein_coding | deleterious(0) | possibly_damaging(0.776) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
PTCH2 | SNV | Missense_Mutation | novel | c.728T>C | p.Val243Ala | p.V243A | Q9Y6C5 | protein_coding | deleterious(0.02) | probably_damaging(0.935) | TCGA-D1-A1O7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTCH2 | SNV | Missense_Mutation | novel | c.587C>T | p.Ala196Val | p.A196V | Q9Y6C5 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PTCH2 | SNV | Missense_Mutation | rs745322399 | c.524G>A | p.Arg175Gln | p.R175Q | Q9Y6C5 | protein_coding | tolerated(1) | benign(0.153) | TCGA-E6-A2P9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTCH2 | SNV | Missense_Mutation | rs200617096 | c.359N>A | p.Arg120His | p.R120H | Q9Y6C5 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTCH2 | SNV | Missense_Mutation | novel | c.3017N>C | p.Ile1006Thr | p.I1006T | Q9Y6C5 | protein_coding | deleterious(0.04) | benign(0.201) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTCH2 | SNV | Missense_Mutation | novel | c.2002N>A | p.Leu668Ile | p.L668I | Q9Y6C5 | protein_coding | tolerated(0.05) | possibly_damaging(0.744) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |