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Gene: POMT2 |
Gene summary for POMT2 |
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Gene information | Species | Human | Gene symbol | POMT2 | Gene ID | 29954 |
Gene name | protein O-mannosyltransferase 2 | |
Gene Alias | LGMD2N | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9UKY4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29954 | POMT2 | LZE22T | Human | Esophagus | ESCC | 7.51e-04 | 2.38e-01 | 0.068 |
29954 | POMT2 | LZE24T | Human | Esophagus | ESCC | 4.84e-08 | 1.71e-01 | 0.0596 |
29954 | POMT2 | P2T-E | Human | Esophagus | ESCC | 5.73e-11 | 1.23e-01 | 0.1177 |
29954 | POMT2 | P4T-E | Human | Esophagus | ESCC | 4.52e-08 | 1.43e-01 | 0.1323 |
29954 | POMT2 | P5T-E | Human | Esophagus | ESCC | 8.80e-03 | 7.33e-02 | 0.1327 |
29954 | POMT2 | P8T-E | Human | Esophagus | ESCC | 8.60e-06 | 1.31e-01 | 0.0889 |
29954 | POMT2 | P9T-E | Human | Esophagus | ESCC | 6.71e-06 | 1.22e-01 | 0.1131 |
29954 | POMT2 | P10T-E | Human | Esophagus | ESCC | 3.32e-16 | 3.26e-01 | 0.116 |
29954 | POMT2 | P11T-E | Human | Esophagus | ESCC | 4.50e-09 | 3.49e-01 | 0.1426 |
29954 | POMT2 | P12T-E | Human | Esophagus | ESCC | 4.10e-15 | 2.56e-01 | 0.1122 |
29954 | POMT2 | P15T-E | Human | Esophagus | ESCC | 1.94e-09 | 2.06e-01 | 0.1149 |
29954 | POMT2 | P16T-E | Human | Esophagus | ESCC | 1.92e-10 | 1.33e-01 | 0.1153 |
29954 | POMT2 | P17T-E | Human | Esophagus | ESCC | 7.26e-03 | 2.40e-01 | 0.1278 |
29954 | POMT2 | P20T-E | Human | Esophagus | ESCC | 1.34e-10 | 1.33e-01 | 0.1124 |
29954 | POMT2 | P21T-E | Human | Esophagus | ESCC | 7.53e-08 | 1.18e-01 | 0.1617 |
29954 | POMT2 | P22T-E | Human | Esophagus | ESCC | 3.88e-09 | 1.48e-01 | 0.1236 |
29954 | POMT2 | P23T-E | Human | Esophagus | ESCC | 2.26e-09 | 1.35e-01 | 0.108 |
29954 | POMT2 | P24T-E | Human | Esophagus | ESCC | 6.19e-07 | 1.56e-01 | 0.1287 |
29954 | POMT2 | P26T-E | Human | Esophagus | ESCC | 2.79e-15 | 2.44e-01 | 0.1276 |
29954 | POMT2 | P27T-E | Human | Esophagus | ESCC | 4.45e-11 | 2.24e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00064931 | Esophagus | ESCC | protein O-linked glycosylation | 51/8552 | 86/18723 | 7.54e-03 | 2.70e-02 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POMT2 | SNV | Missense_Mutation | c.671C>T | p.Pro224Leu | p.P224L | Q9UKY4 | protein_coding | tolerated(0.33) | benign(0.04) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
POMT2 | SNV | Missense_Mutation | c.1760T>C | p.Phe587Ser | p.F587S | Q9UKY4 | protein_coding | deleterious(0.01) | benign(0.009) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
POMT2 | SNV | Missense_Mutation | rs201117837 | c.1816N>A | p.Ala606Thr | p.A606T | Q9UKY4 | protein_coding | tolerated(0.1) | benign(0.079) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
POMT2 | SNV | Missense_Mutation | novel | c.1979N>C | p.Val660Ala | p.V660A | Q9UKY4 | protein_coding | deleterious(0) | benign(0.37) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
POMT2 | SNV | Missense_Mutation | c.307N>C | p.Phe103Leu | p.F103L | Q9UKY4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D7-6528-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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