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Gene: PLEKHH1 |
Gene summary for PLEKHH1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PLEKHH1 | Gene ID | 57475 |
| Gene name | pleckstrin homology, MyTH4 and FERM domain containing H1 | |
| Gene Alias | PLEKHH1 | |
| Cytomap | 14q24.1 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9ULM0 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57475 | PLEKHH1 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.21e-04 | -2.47e-01 | 0.02 |
| 57475 | PLEKHH1 | PTCwithHT_6 | Human | Thyroid | HT | 3.99e-02 | -2.45e-01 | 0.02 |
| 57475 | PLEKHH1 | PTCwithHT_8 | Human | Thyroid | HT | 2.56e-04 | -2.34e-01 | 0.0351 |
| 57475 | PLEKHH1 | PTCwithoutHT_2 | Human | Thyroid | PTC | 9.60e-03 | -2.33e-01 | 0.0419 |
| 57475 | PLEKHH1 | male-WTA | Human | Thyroid | PTC | 2.11e-29 | 1.78e-01 | 0.1037 |
| 57475 | PLEKHH1 | PTC01 | Human | Thyroid | PTC | 4.18e-08 | -3.01e-02 | 0.1899 |
| 57475 | PLEKHH1 | PTC03 | Human | Thyroid | PTC | 5.00e-09 | 2.99e-01 | 0.1784 |
| 57475 | PLEKHH1 | PTC04 | Human | Thyroid | PTC | 2.41e-19 | 2.18e-01 | 0.1927 |
| 57475 | PLEKHH1 | PTC05 | Human | Thyroid | PTC | 1.01e-12 | 4.51e-01 | 0.2065 |
| 57475 | PLEKHH1 | PTC06 | Human | Thyroid | PTC | 2.50e-27 | 6.79e-01 | 0.2057 |
| 57475 | PLEKHH1 | PTC07 | Human | Thyroid | PTC | 1.39e-33 | 4.37e-01 | 0.2044 |
| 57475 | PLEKHH1 | ATC12 | Human | Thyroid | ATC | 4.26e-04 | -2.42e-01 | 0.34 |
| 57475 | PLEKHH1 | ATC13 | Human | Thyroid | ATC | 7.21e-04 | -2.39e-01 | 0.34 |
| 57475 | PLEKHH1 | ATC4 | Human | Thyroid | ATC | 9.68e-04 | -2.41e-01 | 0.34 |
| 57475 | PLEKHH1 | ATC5 | Human | Thyroid | ATC | 1.72e-03 | -2.38e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PLEKHH1 | SNV | Missense_Mutation | rs574404632 | c.1958N>T | p.Thr653Met | p.T653M | Q9ULM0 | protein_coding | tolerated(0.07) | benign(0.16) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLEKHH1 | SNV | Missense_Mutation | novel | c.3044N>A | p.Gly1015Asp | p.G1015D | Q9ULM0 | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLEKHH1 | SNV | Missense_Mutation | c.842N>T | p.Ser281Phe | p.S281F | Q9ULM0 | protein_coding | deleterious_low_confidence(0.02) | benign(0.159) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| PLEKHH1 | SNV | Missense_Mutation | novel | c.754N>A | p.Ala252Thr | p.A252T | Q9ULM0 | protein_coding | tolerated_low_confidence(0.21) | benign(0) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| PLEKHH1 | deletion | Frame_Shift_Del | novel | c.3993delN | p.Thr1334ProfsTer43 | p.T1334Pfs*43 | Q9ULM0 | protein_coding | TCGA-BG-A0VZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | ||
| PLEKHH1 | deletion | Frame_Shift_Del | novel | c.2484delC | p.Met829CysfsTer74 | p.M829Cfs*74 | Q9ULM0 | protein_coding | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| PLEKHH1 | insertion | Frame_Shift_Ins | novel | c.4094_4095insCTGAGGCCCAGGAACTCAGCATAAGAGCT | p.Ter1365CysfsTer2 | p.*1365Cfs*2 | Q9ULM0 | protein_coding | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
| PLEKHH1 | insertion | Frame_Shift_Ins | rs761759640 | c.3999dupC | p.Thr1334HisfsTer56 | p.T1334Hfs*56 | Q9ULM0 | protein_coding | TCGA-D1-A17M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| PLEKHH1 | insertion | Frame_Shift_Ins | novel | c.3887_3888insA | p.Ser1298LysfsTer4 | p.S1298Kfs*4 | Q9ULM0 | protein_coding | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| PLEKHH1 | SNV | Missense_Mutation | novel | c.2107A>C | p.Lys703Gln | p.K703Q | Q9ULM0 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-DD-AAD0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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