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Gene: PJA2 |
Gene summary for PJA2 |
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Gene information | Species | Human | Gene symbol | PJA2 | Gene ID | 9867 |
Gene name | praja ring finger ubiquitin ligase 2 | |
Gene Alias | Neurodap1 | |
Cytomap | 5q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O43164 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9867 | PJA2 | LZE4T | Human | Esophagus | ESCC | 6.36e-18 | 5.63e-01 | 0.0811 |
9867 | PJA2 | LZE5T | Human | Esophagus | ESCC | 5.42e-03 | 1.62e-01 | 0.0514 |
9867 | PJA2 | LZE7T | Human | Esophagus | ESCC | 8.93e-03 | 2.19e-01 | 0.0667 |
9867 | PJA2 | LZE8T | Human | Esophagus | ESCC | 5.94e-05 | 5.86e-02 | 0.067 |
9867 | PJA2 | LZE20T | Human | Esophagus | ESCC | 4.38e-03 | 5.41e-02 | 0.0662 |
9867 | PJA2 | LZE24T | Human | Esophagus | ESCC | 9.34e-11 | 4.17e-01 | 0.0596 |
9867 | PJA2 | LZE21T | Human | Esophagus | ESCC | 2.26e-02 | 9.44e-02 | 0.0655 |
9867 | PJA2 | LZE6T | Human | Esophagus | ESCC | 1.48e-02 | 2.33e-02 | 0.0845 |
9867 | PJA2 | P1T-E | Human | Esophagus | ESCC | 8.88e-07 | 4.56e-01 | 0.0875 |
9867 | PJA2 | P2T-E | Human | Esophagus | ESCC | 2.56e-28 | 4.16e-01 | 0.1177 |
9867 | PJA2 | P4T-E | Human | Esophagus | ESCC | 1.43e-15 | 4.40e-01 | 0.1323 |
9867 | PJA2 | P5T-E | Human | Esophagus | ESCC | 2.58e-18 | 3.44e-01 | 0.1327 |
9867 | PJA2 | P8T-E | Human | Esophagus | ESCC | 3.09e-22 | 2.53e-01 | 0.0889 |
9867 | PJA2 | P9T-E | Human | Esophagus | ESCC | 9.53e-07 | 2.41e-01 | 0.1131 |
9867 | PJA2 | P10T-E | Human | Esophagus | ESCC | 1.93e-17 | 3.40e-01 | 0.116 |
9867 | PJA2 | P11T-E | Human | Esophagus | ESCC | 8.77e-09 | 4.89e-01 | 0.1426 |
9867 | PJA2 | P12T-E | Human | Esophagus | ESCC | 8.16e-18 | 3.24e-01 | 0.1122 |
9867 | PJA2 | P15T-E | Human | Esophagus | ESCC | 4.00e-20 | 4.10e-01 | 0.1149 |
9867 | PJA2 | P16T-E | Human | Esophagus | ESCC | 2.93e-09 | 4.07e-02 | 0.1153 |
9867 | PJA2 | P17T-E | Human | Esophagus | ESCC | 1.46e-09 | 3.82e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003109818 | Esophagus | ESCC | stress-activated protein kinase signaling cascade | 154/8552 | 247/18723 | 8.53e-08 | 1.44e-06 | 154 |
GO:005140318 | Esophagus | ESCC | stress-activated MAPK cascade | 147/8552 | 239/18723 | 5.43e-07 | 7.18e-06 | 147 |
GO:007030217 | Esophagus | ESCC | regulation of stress-activated protein kinase signaling cascade | 119/8552 | 195/18723 | 1.07e-05 | 1.01e-04 | 119 |
GO:003287217 | Esophagus | ESCC | regulation of stress-activated MAPK cascade | 116/8552 | 192/18723 | 2.63e-05 | 2.21e-04 | 116 |
GO:00072549 | Esophagus | ESCC | JNK cascade | 102/8552 | 167/18723 | 4.22e-05 | 3.39e-04 | 102 |
GO:00463289 | Esophagus | ESCC | regulation of JNK cascade | 80/8552 | 133/18723 | 5.35e-04 | 2.95e-03 | 80 |
GO:00703046 | Esophagus | ESCC | positive regulation of stress-activated protein kinase signaling cascade | 74/8552 | 128/18723 | 3.77e-03 | 1.53e-02 | 74 |
GO:00328745 | Esophagus | ESCC | positive regulation of stress-activated MAPK cascade | 72/8552 | 126/18723 | 6.24e-03 | 2.29e-02 | 72 |
GO:00463302 | Esophagus | ESCC | positive regulation of JNK cascade | 52/8552 | 89/18723 | 1.04e-02 | 3.56e-02 | 52 |
GO:00353297 | Esophagus | ESCC | hippo signaling | 26/8552 | 40/18723 | 1.08e-02 | 3.66e-02 | 26 |
GO:00072543 | Liver | NAFLD | JNK cascade | 38/1882 | 167/18723 | 1.12e-06 | 5.52e-05 | 38 |
GO:00514036 | Liver | NAFLD | stress-activated MAPK cascade | 47/1882 | 239/18723 | 5.26e-06 | 1.93e-04 | 47 |
GO:00310986 | Liver | NAFLD | stress-activated protein kinase signaling cascade | 48/1882 | 247/18723 | 5.89e-06 | 2.07e-04 | 48 |
GO:00463283 | Liver | NAFLD | regulation of JNK cascade | 28/1882 | 133/18723 | 1.19e-04 | 2.31e-03 | 28 |
GO:00703025 | Liver | NAFLD | regulation of stress-activated protein kinase signaling cascade | 34/1882 | 195/18723 | 1.01e-03 | 1.20e-02 | 34 |
GO:00328725 | Liver | NAFLD | regulation of stress-activated MAPK cascade | 33/1882 | 192/18723 | 1.52e-03 | 1.65e-02 | 33 |
GO:0035329 | Liver | NAFLD | hippo signaling | 10/1882 | 40/18723 | 5.20e-03 | 4.05e-02 | 10 |
GO:0046330 | Liver | NAFLD | positive regulation of JNK cascade | 17/1882 | 89/18723 | 6.91e-03 | 4.87e-02 | 17 |
GO:003109812 | Liver | Cirrhotic | stress-activated protein kinase signaling cascade | 83/4634 | 247/18723 | 1.04e-03 | 7.28e-03 | 83 |
GO:005140312 | Liver | Cirrhotic | stress-activated MAPK cascade | 80/4634 | 239/18723 | 1.43e-03 | 9.54e-03 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PJA2 | SNV | Missense_Mutation | novel | c.427N>A | p.Glu143Lys | p.E143K | O43164 | protein_coding | deleterious(0.02) | benign(0.351) | TCGA-F7-A50J-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
PJA2 | SNV | Missense_Mutation | novel | c.1253A>G | p.Tyr418Cys | p.Y418C | O43164 | protein_coding | tolerated(0.08) | benign(0.199) | TCGA-P3-A6SX-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | CR |
PJA2 | SNV | Missense_Mutation | c.122N>A | p.Ala41Asp | p.A41D | O43164 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PJA2 | SNV | Missense_Mutation | c.2062N>T | p.Ala688Ser | p.A688S | O43164 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PJA2 | SNV | Missense_Mutation | c.1505N>T | p.Trp502Leu | p.W502L | O43164 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-D7-8578-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PJA2 | SNV | Missense_Mutation | rs752706194 | c.344N>A | p.Ser115Asn | p.S115N | O43164 | protein_coding | tolerated(0.35) | benign(0.076) | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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