|
Gene: PHF3 |
Gene summary for PHF3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PHF3 | Gene ID | 23469 |
Gene name | PHD finger protein 3 | |
Gene Alias | PHF3 | |
Cytomap | 6q12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KP41 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23469 | PHF3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.73e-32 | -8.59e-01 | 0.0155 |
23469 | PHF3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.44e-17 | -8.48e-01 | -0.1808 |
23469 | PHF3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.07e-04 | -8.65e-01 | 0.0216 |
23469 | PHF3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.53e-07 | -5.77e-01 | -0.0811 |
23469 | PHF3 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.99e-03 | -4.83e-01 | -0.1088 |
23469 | PHF3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.95e-03 | -8.49e-01 | -0.2196 |
23469 | PHF3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.32e-16 | -9.05e-01 | -0.1207 |
23469 | PHF3 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.51e-06 | -5.74e-01 | -0.1526 |
23469 | PHF3 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.83e-24 | -7.08e-01 | -0.1464 |
23469 | PHF3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.57e-28 | -7.38e-01 | -0.1001 |
23469 | PHF3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.02e-03 | -5.04e-01 | -0.059 |
23469 | PHF3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.69e-04 | -7.89e-01 | -0.1706 |
23469 | PHF3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.81e-03 | -6.45e-01 | -0.2061 |
23469 | PHF3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.19e-03 | -8.65e-01 | -0.1462 |
23469 | PHF3 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.53e-04 | -6.53e-01 | -0.0842 |
23469 | PHF3 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.49e-03 | -9.38e-01 | -0.00410000000000005 |
23469 | PHF3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.05e-06 | -8.30e-01 | -0.0179 |
23469 | PHF3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.80e-18 | -6.83e-01 | 0.096 |
23469 | PHF3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.45e-06 | -1.03e+00 | 0.0451 |
23469 | PHF3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.18e-03 | -7.61e-01 | 0.0528 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF3 | insertion | Frame_Shift_Ins | rs755026826 | c.2903_2904insT | p.Arg971SerfsTer6 | p.R971Sfs*6 | Q92576 | protein_coding | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
PHF3 | deletion | Frame_Shift_Del | c.3402delN | p.Val1137Ter | p.V1137* | Q92576 | protein_coding | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
PHF3 | insertion | Frame_Shift_Ins | rs779293198 | c.2939_2940insTTCAATTATTTTTCAA | p.Lys980AsnfsTer8 | p.K980Nfs*8 | Q92576 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PHF3 | insertion | Frame_Shift_Ins | novel | c.5948_5949insTGTGAATCACTAT | p.Lys1984ValfsTer10 | p.K1984Vfs*10 | Q92576 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PHF3 | insertion | Frame_Shift_Ins | novel | c.5948_5949insTGTGAATCACTAT | p.Lys1984ValfsTer10 | p.K1984Vfs*10 | Q92576 | protein_coding | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
PHF3 | deletion | Frame_Shift_Del | c.480delA | p.Ala161HisfsTer13 | p.A161Hfs*13 | Q92576 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
PHF3 | insertion | Frame_Shift_Ins | novel | c.4191_4192insT | p.Asn1400Ter | p.N1400* | Q92576 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PHF3 | insertion | Frame_Shift_Ins | novel | c.4137_4138insA | p.Ser1382LysfsTer2 | p.S1382Kfs*2 | Q92576 | protein_coding | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
PHF3 | SNV | Missense_Mutation | novel | c.304N>G | p.Ile102Val | p.I102V | Q92576 | protein_coding | deleterious(0.04) | benign(0.097) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHF3 | SNV | Missense_Mutation | novel | c.818N>C | p.Leu273Ser | p.L273S | Q92576 | protein_coding | tolerated_low_confidence(0.11) | benign(0.149) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |