![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PHF12 |
Gene summary for PHF12 |
![]() |
Gene information | Species | Human | Gene symbol | PHF12 | Gene ID | 57649 |
Gene name | PHD finger protein 12 | |
Gene Alias | PF1 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q96QT6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57649 | PHF12 | LZE4T | Human | Esophagus | ESCC | 7.53e-07 | 1.15e-01 | 0.0811 |
57649 | PHF12 | LZE5T | Human | Esophagus | ESCC | 1.31e-03 | 3.73e-01 | 0.0514 |
57649 | PHF12 | LZE7T | Human | Esophagus | ESCC | 1.61e-07 | 2.83e-01 | 0.0667 |
57649 | PHF12 | LZE20T | Human | Esophagus | ESCC | 8.11e-08 | 1.08e-01 | 0.0662 |
57649 | PHF12 | LZE22T | Human | Esophagus | ESCC | 2.03e-04 | 1.84e-01 | 0.068 |
57649 | PHF12 | LZE24T | Human | Esophagus | ESCC | 9.55e-14 | 1.98e-01 | 0.0596 |
57649 | PHF12 | P1T-E | Human | Esophagus | ESCC | 1.89e-02 | 2.80e-01 | 0.0875 |
57649 | PHF12 | P2T-E | Human | Esophagus | ESCC | 7.81e-22 | 3.48e-01 | 0.1177 |
57649 | PHF12 | P4T-E | Human | Esophagus | ESCC | 1.25e-17 | 2.24e-01 | 0.1323 |
57649 | PHF12 | P5T-E | Human | Esophagus | ESCC | 3.24e-22 | 2.11e-01 | 0.1327 |
57649 | PHF12 | P8T-E | Human | Esophagus | ESCC | 1.43e-10 | 1.60e-01 | 0.0889 |
57649 | PHF12 | P9T-E | Human | Esophagus | ESCC | 6.02e-12 | 1.08e-01 | 0.1131 |
57649 | PHF12 | P10T-E | Human | Esophagus | ESCC | 8.03e-24 | 4.52e-01 | 0.116 |
57649 | PHF12 | P11T-E | Human | Esophagus | ESCC | 1.21e-08 | 2.27e-01 | 0.1426 |
57649 | PHF12 | P12T-E | Human | Esophagus | ESCC | 2.79e-14 | 2.27e-01 | 0.1122 |
57649 | PHF12 | P15T-E | Human | Esophagus | ESCC | 3.46e-20 | 2.78e-01 | 0.1149 |
57649 | PHF12 | P16T-E | Human | Esophagus | ESCC | 1.52e-14 | 1.98e-01 | 0.1153 |
57649 | PHF12 | P17T-E | Human | Esophagus | ESCC | 3.12e-05 | 1.86e-01 | 0.1278 |
57649 | PHF12 | P20T-E | Human | Esophagus | ESCC | 2.26e-05 | 5.96e-02 | 0.1124 |
57649 | PHF12 | P21T-E | Human | Esophagus | ESCC | 1.72e-08 | 1.06e-01 | 0.1617 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF12 | insertion | Frame_Shift_Ins | novel | c.130_131insGTCAGGAGTT | p.Glu44GlyfsTer21 | p.E44Gfs*21 | Q96QT6 | protein_coding | TCGA-FI-A2F9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PHF12 | SNV | Missense_Mutation | c.403N>T | p.Asp135Tyr | p.D135Y | Q96QT6 | protein_coding | deleterious(0.01) | probably_damaging(0.936) | TCGA-DD-A114-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PHF12 | SNV | Missense_Mutation | c.484N>G | p.Ser162Gly | p.S162G | Q96QT6 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-ES-A2HT-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PHF12 | SNV | Missense_Mutation | novel | c.116G>A | p.Arg39His | p.R39H | Q96QT6 | protein_coding | deleterious(0.01) | possibly_damaging(0.474) | TCGA-55-6982-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD |
PHF12 | SNV | Missense_Mutation | novel | c.2682N>T | p.Arg894Ser | p.R894S | Q96QT6 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PHF12 | SNV | Missense_Mutation | c.500N>T | p.Pro167Leu | p.P167L | Q96QT6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PHF12 | SNV | Missense_Mutation | rs766063225 | c.745A>G | p.Thr249Ala | p.T249A | Q96QT6 | protein_coding | tolerated(0.77) | benign(0.003) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PHF12 | SNV | Missense_Mutation | novel | c.1642N>T | p.Asn548Tyr | p.N548Y | Q96QT6 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PHF12 | SNV | Missense_Mutation | novel | c.623N>T | p.Arg208Leu | p.R208L | Q96QT6 | protein_coding | deleterious(0.01) | possibly_damaging(0.605) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PHF12 | SNV | Missense_Mutation | rs769477357 | c.2792N>T | p.Ser931Leu | p.S931L | Q96QT6 | protein_coding | deleterious(0) | benign(0.391) | TCGA-52-7809-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |