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Gene: PHF1 |
Gene summary for PHF1 |
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Gene information | Species | Human | Gene symbol | PHF1 | Gene ID | 5252 |
Gene name | PHD finger protein 1 | |
Gene Alias | MTF2L2 | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A140VJR4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5252 | PHF1 | LZE4T | Human | Esophagus | ESCC | 7.65e-07 | 8.03e-02 | 0.0811 |
5252 | PHF1 | LZE5T | Human | Esophagus | ESCC | 5.01e-03 | 1.84e-01 | 0.0514 |
5252 | PHF1 | LZE8T | Human | Esophagus | ESCC | 3.01e-03 | -7.49e-03 | 0.067 |
5252 | PHF1 | LZE20T | Human | Esophagus | ESCC | 2.18e-13 | 3.21e-01 | 0.0662 |
5252 | PHF1 | LZE22T | Human | Esophagus | ESCC | 6.43e-06 | 3.87e-01 | 0.068 |
5252 | PHF1 | LZE24T | Human | Esophagus | ESCC | 2.92e-16 | 4.77e-01 | 0.0596 |
5252 | PHF1 | LZE21T | Human | Esophagus | ESCC | 7.54e-06 | 3.77e-01 | 0.0655 |
5252 | PHF1 | LZE6T | Human | Esophagus | ESCC | 3.97e-05 | 3.62e-02 | 0.0845 |
5252 | PHF1 | P1T-E | Human | Esophagus | ESCC | 8.89e-04 | 4.33e-01 | 0.0875 |
5252 | PHF1 | P2T-E | Human | Esophagus | ESCC | 9.01e-32 | 5.60e-01 | 0.1177 |
5252 | PHF1 | P4T-E | Human | Esophagus | ESCC | 1.75e-13 | 2.00e-01 | 0.1323 |
5252 | PHF1 | P5T-E | Human | Esophagus | ESCC | 3.61e-09 | 1.37e-02 | 0.1327 |
5252 | PHF1 | P8T-E | Human | Esophagus | ESCC | 4.91e-22 | 1.77e-01 | 0.0889 |
5252 | PHF1 | P9T-E | Human | Esophagus | ESCC | 5.14e-05 | 1.32e-01 | 0.1131 |
5252 | PHF1 | P10T-E | Human | Esophagus | ESCC | 9.41e-16 | 2.13e-01 | 0.116 |
5252 | PHF1 | P11T-E | Human | Esophagus | ESCC | 2.00e-22 | 6.26e-01 | 0.1426 |
5252 | PHF1 | P12T-E | Human | Esophagus | ESCC | 5.68e-30 | 3.01e-01 | 0.1122 |
5252 | PHF1 | P15T-E | Human | Esophagus | ESCC | 1.48e-20 | 2.58e-01 | 0.1149 |
5252 | PHF1 | P16T-E | Human | Esophagus | ESCC | 1.49e-21 | 3.22e-01 | 0.1153 |
5252 | PHF1 | P17T-E | Human | Esophagus | ESCC | 2.23e-07 | 4.82e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00182054 | Cervix | CC | peptidyl-lysine modification | 62/2311 | 376/18723 | 1.04e-02 | 4.97e-02 | 62 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:00165702 | Colorectum | CRC | histone modification | 75/2078 | 463/18723 | 4.95e-04 | 7.06e-03 | 75 |
GO:00182057 | Esophagus | HGIN | peptidyl-lysine modification | 88/2587 | 376/18723 | 2.99e-07 | 1.39e-05 | 88 |
GO:00165708 | Esophagus | HGIN | histone modification | 92/2587 | 463/18723 | 1.70e-04 | 3.30e-03 | 92 |
GO:00064735 | Esophagus | HGIN | protein acetylation | 45/2587 | 201/18723 | 6.17e-04 | 8.58e-03 | 45 |
GO:00183945 | Esophagus | HGIN | peptidyl-lysine acetylation | 39/2587 | 169/18723 | 7.46e-04 | 9.90e-03 | 39 |
GO:00435435 | Esophagus | HGIN | protein acylation | 51/2587 | 243/18723 | 1.33e-03 | 1.57e-02 | 51 |
GO:00064755 | Esophagus | HGIN | internal protein amino acid acetylation | 36/2587 | 160/18723 | 1.87e-03 | 2.01e-02 | 36 |
GO:00183935 | Esophagus | HGIN | internal peptidyl-lysine acetylation | 35/2587 | 158/18723 | 2.82e-03 | 2.75e-02 | 35 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF1 | deletion | Frame_Shift_Del | c.16delC | p.Arg6GlyfsTer2 | p.R6Gfs*2 | O43189 | protein_coding | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
PHF1 | deletion | Frame_Shift_Del | c.16delC | p.Arg6GlyfsTer2 | p.R6Gfs*2 | O43189 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |||
PHF1 | deletion | Frame_Shift_Del | novel | c.1013delC | p.Pro338LeufsTer39 | p.P338Lfs*39 | O43189 | protein_coding | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | ||
PHF1 | deletion | Frame_Shift_Del | novel | c.1637_1659delNNNNNNNNNNNNNNNNNNNNNNN | p.Ala546ValfsTer7 | p.A546Vfs*7 | O43189 | protein_coding | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD | ||
PHF1 | insertion | Frame_Shift_Ins | rs770498402 | c.16dupC | p.Arg6ProfsTer38 | p.R6Pfs*38 | O43189 | protein_coding | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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