![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PCSK6 |
Gene summary for PCSK6 |
![]() |
Gene information | Species | Human | Gene symbol | PCSK6 | Gene ID | 5046 |
Gene name | proprotein convertase subtilisin/kexin type 6 | |
Gene Alias | PACE4 | |
Cytomap | 15q26.3 | |
Gene Type | protein-coding | GO ID | GO:0000578 | UniProtAcc | A2RQD9 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5046 | PCSK6 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.29e-21 | 8.15e-01 | -0.1954 |
5046 | PCSK6 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.39e-05 | 5.64e-01 | -0.1526 |
5046 | PCSK6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.73e-03 | 4.92e-01 | -0.059 |
5046 | PCSK6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.26e-05 | -2.80e-01 | 0.294 |
5046 | PCSK6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.49e-09 | -3.62e-01 | 0.3859 |
5046 | PCSK6 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.77e-10 | -3.92e-01 | 0.3005 |
5046 | PCSK6 | A001-C-207 | Human | Colorectum | FAP | 2.35e-02 | -3.00e-01 | 0.1278 |
5046 | PCSK6 | A015-C-203 | Human | Colorectum | FAP | 1.01e-15 | -2.99e-01 | -0.1294 |
5046 | PCSK6 | A015-C-204 | Human | Colorectum | FAP | 4.50e-02 | -2.77e-01 | -0.0228 |
5046 | PCSK6 | A002-C-201 | Human | Colorectum | FAP | 2.98e-07 | -2.85e-01 | 0.0324 |
5046 | PCSK6 | A001-C-119 | Human | Colorectum | FAP | 1.34e-04 | -3.96e-01 | -0.1557 |
5046 | PCSK6 | A001-C-108 | Human | Colorectum | FAP | 4.37e-09 | -2.83e-01 | -0.0272 |
5046 | PCSK6 | A002-C-205 | Human | Colorectum | FAP | 2.28e-11 | -3.89e-01 | -0.1236 |
5046 | PCSK6 | A001-C-104 | Human | Colorectum | FAP | 9.23e-06 | -2.76e-01 | 0.0184 |
5046 | PCSK6 | A015-C-005 | Human | Colorectum | FAP | 1.02e-11 | -4.80e-01 | -0.0336 |
5046 | PCSK6 | A015-C-006 | Human | Colorectum | FAP | 2.48e-06 | -3.05e-01 | -0.0994 |
5046 | PCSK6 | A015-C-106 | Human | Colorectum | FAP | 1.31e-09 | -3.23e-01 | -0.0511 |
5046 | PCSK6 | A002-C-114 | Human | Colorectum | FAP | 2.59e-07 | -2.37e-01 | -0.1561 |
5046 | PCSK6 | A015-C-104 | Human | Colorectum | FAP | 1.72e-21 | -4.24e-01 | -0.1899 |
5046 | PCSK6 | A001-C-014 | Human | Colorectum | FAP | 5.01e-10 | -3.22e-01 | 0.0135 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
GO:00164851 | Colorectum | SER | protein processing | 55/2897 | 225/18723 | 2.84e-04 | 4.67e-03 | 55 |
GO:00516042 | Colorectum | MSS | protein maturation | 75/3467 | 294/18723 | 1.70e-03 | 1.53e-02 | 75 |
GO:00071781 | Colorectum | MSS | transmembrane receptor protein serine/threonine kinase signaling pathway | 86/3467 | 355/18723 | 4.04e-03 | 2.95e-02 | 86 |
GO:00164852 | Colorectum | MSS | protein processing | 57/3467 | 225/18723 | 6.60e-03 | 4.38e-02 | 57 |
GO:00071782 | Colorectum | FAP | transmembrane receptor protein serine/threonine kinase signaling pathway | 81/2622 | 355/18723 | 4.28e-06 | 1.46e-04 | 81 |
GO:0071772 | Colorectum | FAP | response to BMP | 37/2622 | 165/18723 | 2.20e-03 | 1.80e-02 | 37 |
GO:0071773 | Colorectum | FAP | cellular response to BMP stimulus | 37/2622 | 165/18723 | 2.20e-03 | 1.80e-02 | 37 |
GO:0090092 | Colorectum | FAP | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 52/2622 | 256/18723 | 3.33e-03 | 2.44e-02 | 52 |
GO:0030509 | Colorectum | FAP | BMP signaling pathway | 34/2622 | 152/18723 | 3.38e-03 | 2.47e-02 | 34 |
GO:0009952 | Colorectum | FAP | anterior/posterior pattern specification | 41/2622 | 201/18723 | 7.82e-03 | 4.63e-02 | 41 |
GO:00071783 | Colorectum | CRC | transmembrane receptor protein serine/threonine kinase signaling pathway | 66/2078 | 355/18723 | 1.74e-05 | 5.28e-04 | 66 |
GO:00305091 | Colorectum | CRC | BMP signaling pathway | 31/2078 | 152/18723 | 5.73e-04 | 7.89e-03 | 31 |
GO:00900921 | Colorectum | CRC | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 46/2078 | 256/18723 | 6.66e-04 | 8.77e-03 | 46 |
GO:00717721 | Colorectum | CRC | response to BMP | 32/2078 | 165/18723 | 1.16e-03 | 1.33e-02 | 32 |
GO:00717731 | Colorectum | CRC | cellular response to BMP stimulus | 32/2078 | 165/18723 | 1.16e-03 | 1.33e-02 | 32 |
GO:00099521 | Colorectum | CRC | anterior/posterior pattern specification | 36/2078 | 201/18723 | 2.56e-03 | 2.40e-02 | 36 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCSK6 | SNV | Missense_Mutation | c.1761A>T | p.Glu587Asp | p.E587D | P29122 | protein_coding | deleterious(0.04) | possibly_damaging(0.755) | TCGA-44-6147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCSK6 | SNV | Missense_Mutation | novel | c.658N>T | p.Asp220Tyr | p.D220Y | P29122 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-1595-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK6 | SNV | Missense_Mutation | novel | c.2620N>T | p.Asp874Tyr | p.D874Y | P29122 | protein_coding | deleterious(0) | possibly_damaging(0.457) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCSK6 | SNV | Missense_Mutation | novel | c.2303G>A | p.Arg768His | p.R768H | P29122 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-64-5774-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PCSK6 | SNV | Missense_Mutation | novel | c.1031C>T | p.Ala344Val | p.A344V | P29122 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PCSK6 | SNV | Missense_Mutation | novel | c.1235N>T | p.Cys412Phe | p.C412F | P29122 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-83-5908-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCSK6 | SNV | Missense_Mutation | novel | c.2008G>A | p.Glu670Lys | p.E670K | P29122 | protein_coding | tolerated(0.15) | benign(0.024) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PCSK6 | SNV | Missense_Mutation | novel | c.983N>G | p.Tyr328Cys | p.Y328C | P29122 | protein_coding | tolerated(0.1) | possibly_damaging(0.863) | TCGA-34-2604-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK6 | SNV | Missense_Mutation | c.710G>A | p.Arg237Gln | p.R237Q | P29122 | protein_coding | tolerated(0.19) | probably_damaging(0.987) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PCSK6 | SNV | Missense_Mutation | novel | c.1076G>A | p.Gly359Asp | p.G359D | P29122 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-58-8390-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5046 | PCSK6 | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | inhibitor | 252166858 | ||
5046 | PCSK6 | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | inhibitor | 178103178 | ||
5046 | PCSK6 | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | inhibitor | 252166848 | ||
5046 | PCSK6 | PROTEASE, DRUGGABLE GENOME, ENZYME, CELL SURFACE | inhibitor | 252166868 |
Page: 1 |