|
Gene: PCK1 |
Gene summary for PCK1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | PCK1 | Gene ID | 5105 |
Gene name | phosphoenolpyruvate carboxykinase 1 | |
Gene Alias | PCKDC | |
Cytomap | 20q13.31 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | P35558 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5105 | PCK1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.87e-07 | -4.85e-01 | 0.0155 |
5105 | PCK1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.21e-37 | 1.24e+00 | -0.1954 |
5105 | PCK1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.43e-05 | 1.52e+00 | -0.2602 |
5105 | PCK1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.34e-08 | 1.14e+00 | -0.2061 |
5105 | PCK1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.85e-03 | -4.87e-01 | 0.0338 |
5105 | PCK1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.20e-07 | -4.46e-01 | 0.0674 |
5105 | PCK1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.57e-07 | -5.71e-01 | 0.0588 |
5105 | PCK1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.66e-03 | 7.00e-01 | 0.3859 |
5105 | PCK1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.92e-19 | -5.62e-01 | 0.3005 |
5105 | PCK1 | F007 | Human | Colorectum | FAP | 6.22e-08 | -5.44e-01 | 0.1176 |
5105 | PCK1 | A002-C-010 | Human | Colorectum | FAP | 1.27e-11 | -5.35e-01 | 0.242 |
5105 | PCK1 | A001-C-207 | Human | Colorectum | FAP | 1.10e-07 | -4.91e-01 | 0.1278 |
5105 | PCK1 | A015-C-203 | Human | Colorectum | FAP | 2.80e-09 | -3.48e-01 | -0.1294 |
5105 | PCK1 | A015-C-204 | Human | Colorectum | FAP | 2.78e-06 | -4.73e-01 | -0.0228 |
5105 | PCK1 | A002-C-201 | Human | Colorectum | FAP | 1.39e-14 | -5.20e-01 | 0.0324 |
5105 | PCK1 | A002-C-203 | Human | Colorectum | FAP | 2.09e-21 | -5.60e-01 | 0.2786 |
5105 | PCK1 | A001-C-119 | Human | Colorectum | FAP | 6.58e-04 | -4.49e-01 | -0.1557 |
5105 | PCK1 | A001-C-108 | Human | Colorectum | FAP | 1.41e-15 | -5.23e-01 | -0.0272 |
5105 | PCK1 | A002-C-205 | Human | Colorectum | FAP | 3.98e-15 | -5.31e-01 | -0.1236 |
5105 | PCK1 | A001-C-104 | Human | Colorectum | FAP | 2.10e-08 | -4.07e-01 | 0.0184 |
Page: 1 2 3 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0006090 | Colorectum | AD | pyruvate metabolic process | 47/3918 | 106/18723 | 4.85e-08 | 2.55e-06 | 47 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0009743 | Colorectum | AD | response to carbohydrate | 86/3918 | 253/18723 | 8.43e-07 | 2.90e-05 | 86 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0034284 | Colorectum | AD | response to monosaccharide | 76/3918 | 225/18723 | 4.64e-06 | 1.23e-04 | 76 |
GO:0061008 | Colorectum | AD | hepaticobiliary system development | 55/3918 | 150/18723 | 6.34e-06 | 1.59e-04 | 55 |
GO:0001889 | Colorectum | AD | liver development | 54/3918 | 147/18723 | 7.20e-06 | 1.77e-04 | 54 |
GO:0033500 | Colorectum | AD | carbohydrate homeostasis | 84/3918 | 259/18723 | 9.10e-06 | 2.15e-04 | 84 |
GO:0009746 | Colorectum | AD | response to hexose | 73/3918 | 219/18723 | 1.20e-05 | 2.65e-04 | 73 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:0009749 | Colorectum | AD | response to glucose | 71/3918 | 212/18723 | 1.31e-05 | 2.85e-04 | 71 |
GO:0048545 | Colorectum | AD | response to steroid hormone | 104/3918 | 339/18723 | 1.33e-05 | 2.90e-04 | 104 |
GO:0042593 | Colorectum | AD | glucose homeostasis | 83/3918 | 258/18723 | 1.44e-05 | 3.11e-04 | 83 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa00020 | Colorectum | AD | Citrate cycle (TCA cycle) | 20/2092 | 30/8465 | 1.43e-06 | 1.77e-05 | 1.13e-05 | 20 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa04964 | Colorectum | AD | Proximal tubule bicarbonate reclamation | 11/2092 | 23/8465 | 1.35e-02 | 4.86e-02 | 3.10e-02 | 11 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa000201 | Colorectum | AD | Citrate cycle (TCA cycle) | 20/2092 | 30/8465 | 1.43e-06 | 1.77e-05 | 1.13e-05 | 20 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa049641 | Colorectum | AD | Proximal tubule bicarbonate reclamation | 11/2092 | 23/8465 | 1.35e-02 | 4.86e-02 | 3.10e-02 | 11 |
hsa006202 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa000202 | Colorectum | SER | Citrate cycle (TCA cycle) | 16/1580 | 30/8465 | 2.06e-05 | 2.74e-04 | 1.99e-04 | 16 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa000102 | Colorectum | SER | Glycolysis / Gluconeogenesis | 24/1580 | 67/8465 | 6.62e-04 | 5.36e-03 | 3.89e-03 | 24 |
hsa049642 | Colorectum | SER | Proximal tubule bicarbonate reclamation | 10/1580 | 23/8465 | 5.33e-03 | 3.28e-02 | 2.38e-02 | 10 |
hsa006203 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa000203 | Colorectum | SER | Citrate cycle (TCA cycle) | 16/1580 | 30/8465 | 2.06e-05 | 2.74e-04 | 1.99e-04 | 16 |
hsa049223 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
Page: 1 2 3 4 5 6 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCK1 | SNV | Missense_Mutation | rs747837917 | c.859N>T | p.Ala287Ser | p.A287S | P35558 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCK1 | SNV | Missense_Mutation | c.1120N>T | p.Asp374Tyr | p.D374Y | P35558 | protein_coding | deleterious(0) | possibly_damaging(0.454) | TCGA-75-6214-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | PD | |
PCK1 | SNV | Missense_Mutation | novel | c.298N>G | p.Arg100Gly | p.R100G | P35558 | protein_coding | tolerated(0.07) | benign(0.2) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCK1 | SNV | Missense_Mutation | novel | c.1429C>A | p.His477Asn | p.H477N | P35558 | protein_coding | tolerated(0.08) | possibly_damaging(0.543) | TCGA-J2-A4AD-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PCK1 | SNV | Missense_Mutation | c.818N>A | p.Pro273His | p.P273H | P35558 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
PCK1 | SNV | Missense_Mutation | rs762530982 | c.595C>T | p.Pro199Ser | p.P199S | P35558 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCK1 | SNV | Missense_Mutation | novel | c.70N>A | p.Pro24Thr | p.P24T | P35558 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCK1 | SNV | Missense_Mutation | rs545533074 | c.1072A>G | p.Thr358Ala | p.T358A | P35558 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PCK1 | SNV | Missense_Mutation | novel | c.1232N>T | p.Ser411Ile | p.S411I | P35558 | protein_coding | deleterious(0.03) | benign(0.029) | TCGA-39-5034-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PCK1 | SNV | Missense_Mutation | novel | c.350N>G | p.Met117Arg | p.M117R | P35558 | protein_coding | tolerated(0.14) | benign(0.043) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |