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Gene: PCIF1 |
Gene summary for PCIF1 |
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Gene information | Species | Human | Gene symbol | PCIF1 | Gene ID | 63935 |
Gene name | phosphorylated CTD interacting factor 1 | |
Gene Alias | C20orf67 | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q9H4Z3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63935 | PCIF1 | LZE4T | Human | Esophagus | ESCC | 7.16e-18 | 4.63e-01 | 0.0811 |
63935 | PCIF1 | LZE7T | Human | Esophagus | ESCC | 4.98e-09 | 3.85e-01 | 0.0667 |
63935 | PCIF1 | LZE8T | Human | Esophagus | ESCC | 5.57e-13 | 3.89e-01 | 0.067 |
63935 | PCIF1 | LZE20T | Human | Esophagus | ESCC | 3.55e-03 | 1.70e-01 | 0.0662 |
63935 | PCIF1 | LZE24T | Human | Esophagus | ESCC | 6.57e-21 | 5.22e-01 | 0.0596 |
63935 | PCIF1 | LZE21T | Human | Esophagus | ESCC | 3.64e-04 | 2.96e-01 | 0.0655 |
63935 | PCIF1 | LZE6T | Human | Esophagus | ESCC | 2.26e-10 | 2.63e-01 | 0.0845 |
63935 | PCIF1 | P1T-E | Human | Esophagus | ESCC | 1.23e-13 | 4.04e-01 | 0.0875 |
63935 | PCIF1 | P2T-E | Human | Esophagus | ESCC | 1.79e-29 | 5.12e-01 | 0.1177 |
63935 | PCIF1 | P4T-E | Human | Esophagus | ESCC | 2.98e-25 | 4.79e-01 | 0.1323 |
63935 | PCIF1 | P5T-E | Human | Esophagus | ESCC | 1.13e-09 | 2.05e-01 | 0.1327 |
63935 | PCIF1 | P8T-E | Human | Esophagus | ESCC | 3.26e-32 | 5.47e-01 | 0.0889 |
63935 | PCIF1 | P9T-E | Human | Esophagus | ESCC | 9.31e-19 | 4.35e-01 | 0.1131 |
63935 | PCIF1 | P10T-E | Human | Esophagus | ESCC | 1.58e-47 | 7.97e-01 | 0.116 |
63935 | PCIF1 | P11T-E | Human | Esophagus | ESCC | 4.40e-12 | 5.83e-01 | 0.1426 |
63935 | PCIF1 | P12T-E | Human | Esophagus | ESCC | 1.05e-41 | 8.03e-01 | 0.1122 |
63935 | PCIF1 | P15T-E | Human | Esophagus | ESCC | 1.30e-35 | 7.50e-01 | 0.1149 |
63935 | PCIF1 | P16T-E | Human | Esophagus | ESCC | 8.37e-37 | 7.27e-01 | 0.1153 |
63935 | PCIF1 | P17T-E | Human | Esophagus | ESCC | 5.84e-15 | 6.12e-01 | 0.1278 |
63935 | PCIF1 | P19T-E | Human | Esophagus | ESCC | 3.09e-02 | 5.32e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:0045727111 | Esophagus | ESCC | positive regulation of translation | 107/8552 | 136/18723 | 2.79e-15 | 1.68e-13 | 107 |
GO:0034250111 | Esophagus | ESCC | positive regulation of cellular amide metabolic process | 123/8552 | 162/18723 | 3.32e-15 | 1.93e-13 | 123 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00800092 | Esophagus | ESCC | mRNA methylation | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00165561 | Esophagus | ESCC | mRNA modification | 21/8552 | 27/18723 | 6.88e-04 | 3.61e-03 | 21 |
GO:003424914 | Esophagus | ESCC | negative regulation of cellular amide metabolic process | 144/8552 | 273/18723 | 1.08e-02 | 3.67e-02 | 144 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:004572712 | Liver | HCC | positive regulation of translation | 97/7958 | 136/18723 | 8.51e-12 | 3.55e-10 | 97 |
GO:003425022 | Liver | HCC | positive regulation of cellular amide metabolic process | 110/7958 | 162/18723 | 5.14e-11 | 1.92e-09 | 110 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0001510 | Liver | HCC | RNA methylation | 53/7958 | 83/18723 | 6.96e-05 | 6.29e-04 | 53 |
GO:003424921 | Liver | HCC | negative regulation of cellular amide metabolic process | 144/7958 | 273/18723 | 3.80e-04 | 2.61e-03 | 144 |
GO:001714821 | Liver | HCC | negative regulation of translation | 129/7958 | 245/18723 | 8.14e-04 | 4.87e-03 | 129 |
GO:0080009 | Liver | HCC | mRNA methylation | 12/7958 | 16/18723 | 8.74e-03 | 3.40e-02 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCIF1 | SNV | Missense_Mutation | novel | c.815N>A | p.Pro272His | p.P272H | Q9H4Z3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CR-7398-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCIF1 | SNV | Missense_Mutation | novel | c.454N>G | p.Thr152Ala | p.T152A | Q9H4Z3 | protein_coding | tolerated(0.78) | benign(0) | TCGA-CV-A6K0-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PCIF1 | SNV | Missense_Mutation | novel | c.1448N>C | p.Leu483Pro | p.L483P | Q9H4Z3 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-D6-6516-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCIF1 | SNV | Missense_Mutation | novel | c.92N>G | p.Pro31Arg | p.P31R | Q9H4Z3 | protein_coding | deleterious(0) | possibly_damaging(0.809) | TCGA-P3-A6T6-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
PCIF1 | SNV | Missense_Mutation | rs746616095 | c.1816N>T | p.Arg606Cys | p.R606C | Q9H4Z3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PCIF1 | SNV | Missense_Mutation | c.683C>A | p.Pro228His | p.P228H | Q9H4Z3 | protein_coding | deleterious(0.01) | probably_damaging(0.962) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCIF1 | SNV | Missense_Mutation | c.1318N>T | p.Ser440Cys | p.S440C | Q9H4Z3 | protein_coding | deleterious(0) | benign(0.412) | TCGA-D7-8570-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | plfe | SD | |
PCIF1 | SNV | Missense_Mutation | c.337N>T | p.Arg113Trp | p.R113W | Q9H4Z3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCIF1 | SNV | Missense_Mutation | rs769011759 | c.1961N>T | p.Ala654Val | p.A654V | Q9H4Z3 | protein_coding | tolerated(0.09) | benign(0) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCIF1 | SNV | Missense_Mutation | novel | c.668N>A | p.Arg223Gln | p.R223Q | Q9H4Z3 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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