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Gene: OPRK1 |
Gene summary for OPRK1 |
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Gene information | Species | Human | Gene symbol | OPRK1 | Gene ID | 4986 |
Gene name | opioid receptor kappa 1 | |
Gene Alias | K-OR-1 | |
Cytomap | 8q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P41145 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4986 | OPRK1 | S014 | Human | Liver | HCC | 3.20e-26 | 8.87e-01 | 0.2254 |
4986 | OPRK1 | S015 | Human | Liver | HCC | 1.42e-09 | 3.49e-01 | 0.2375 |
4986 | OPRK1 | S016 | Human | Liver | HCC | 2.44e-34 | 9.97e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003286821 | Liver | HCC | response to insulin | 172/7958 | 264/18723 | 7.14e-14 | 4.23e-12 | 172 |
GO:004343422 | Liver | HCC | response to peptide hormone | 247/7958 | 414/18723 | 9.55e-13 | 4.77e-11 | 247 |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
GO:000974322 | Liver | HCC | response to carbohydrate | 149/7958 | 253/18723 | 9.55e-08 | 1.89e-06 | 149 |
GO:00516071 | Liver | HCC | defense response to virus | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:01405461 | Liver | HCC | defense response to symbiont | 151/7958 | 265/18723 | 1.27e-06 | 1.85e-05 | 151 |
GO:003428422 | Liver | HCC | response to monosaccharide | 131/7958 | 225/18723 | 1.32e-06 | 1.91e-05 | 131 |
GO:000974622 | Liver | HCC | response to hexose | 126/7958 | 219/18723 | 4.81e-06 | 6.06e-05 | 126 |
GO:000974912 | Liver | HCC | response to glucose | 121/7958 | 212/18723 | 1.24e-05 | 1.39e-04 | 121 |
GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
GO:009730522 | Liver | HCC | response to alcohol | 138/7958 | 253/18723 | 6.91e-05 | 6.26e-04 | 138 |
GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
GO:004259322 | Liver | HCC | glucose homeostasis | 137/7958 | 258/18723 | 3.59e-04 | 2.49e-03 | 137 |
GO:003350022 | Liver | HCC | carbohydrate homeostasis | 137/7958 | 259/18723 | 4.45e-04 | 2.98e-03 | 137 |
GO:000167822 | Liver | HCC | cellular glucose homeostasis | 95/7958 | 172/18723 | 4.95e-04 | 3.24e-03 | 95 |
GO:007133112 | Liver | HCC | cellular response to hexose stimulus | 85/7958 | 153/18723 | 7.47e-04 | 4.52e-03 | 85 |
GO:007133312 | Liver | HCC | cellular response to glucose stimulus | 84/7958 | 151/18723 | 7.57e-04 | 4.56e-03 | 84 |
GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
GO:007132612 | Liver | HCC | cellular response to monosaccharide stimulus | 85/7958 | 154/18723 | 9.78e-04 | 5.68e-03 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OPRK1 | SNV | Missense_Mutation | c.883N>A | p.Leu295Met | p.L295M | P41145 | protein_coding | tolerated(0.06) | possibly_damaging(0.824) | TCGA-67-6217-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD | |
OPRK1 | SNV | Missense_Mutation | c.944N>T | p.Cys315Phe | p.C315F | P41145 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-69-8254-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OPRK1 | SNV | Missense_Mutation | rs747565006 | c.400G>A | p.Val134Ile | p.V134I | P41145 | protein_coding | tolerated(0.14) | benign(0.344) | TCGA-69-A59K-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
OPRK1 | SNV | Missense_Mutation | rs148980561 | c.356N>T | p.Tyr119Phe | p.Y119F | P41145 | protein_coding | tolerated(0.08) | benign(0.208) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
OPRK1 | SNV | Missense_Mutation | c.113G>C | p.Ser38Thr | p.S38T | P41145 | protein_coding | tolerated(0.45) | benign(0.009) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OPRK1 | SNV | Missense_Mutation | c.100N>C | p.Ala34Pro | p.A34P | P41145 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-MP-A4TH-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OPRK1 | SNV | Missense_Mutation | novel | c.922G>C | p.Ala308Pro | p.A308P | P41145 | protein_coding | tolerated(0.1) | possibly_damaging(0.699) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OPRK1 | SNV | Missense_Mutation | c.514N>A | p.Pro172Thr | p.P172T | P41145 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-56-5897-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OPRK1 | SNV | Missense_Mutation | novel | c.971N>T | p.Ser324Ile | p.S324I | P41145 | protein_coding | deleterious(0.03) | probably_damaging(0.98) | TCGA-77-8128-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
OPRK1 | SNV | Missense_Mutation | novel | c.246C>G | p.Phe82Leu | p.F82L | P41145 | protein_coding | deleterious(0) | possibly_damaging(0.731) | TCGA-77-8154-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650321 | ||
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | COCAINE | COCAINE | ||
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | partial agonist | CHEMBL2062276 | LEVALLORPHAN TARTRATE | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | SALVINORIN A | SALVINORIN A | 22204910 | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | HYDROMORPHONE | HYDROMORPHONE | ||
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651213 | ||
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650582 | ||
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135650689 | NALTRINDOLE | |
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 178100466 | ||
4986 | OPRK1 | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135650868 | QUADAZOCINE |
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