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Gene: OPLAH |
Gene summary for OPLAH |
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Gene information | Species | Human | Gene symbol | OPLAH | Gene ID | 26873 |
Gene name | 5-oxoprolinase, ATP-hydrolysing | |
Gene Alias | 5-Opase | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006518 | UniProtAcc | O14841 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26873 | OPLAH | LZE24T | Human | Esophagus | ESCC | 1.27e-06 | 1.48e-01 | 0.0596 |
26873 | OPLAH | P1T-E | Human | Esophagus | ESCC | 2.56e-05 | 2.80e-01 | 0.0875 |
26873 | OPLAH | P2T-E | Human | Esophagus | ESCC | 4.59e-07 | 1.01e-01 | 0.1177 |
26873 | OPLAH | P4T-E | Human | Esophagus | ESCC | 5.63e-03 | 1.13e-01 | 0.1323 |
26873 | OPLAH | P5T-E | Human | Esophagus | ESCC | 2.88e-09 | 9.76e-02 | 0.1327 |
26873 | OPLAH | P8T-E | Human | Esophagus | ESCC | 1.01e-10 | 1.01e-01 | 0.0889 |
26873 | OPLAH | P9T-E | Human | Esophagus | ESCC | 1.48e-08 | 1.66e-01 | 0.1131 |
26873 | OPLAH | P10T-E | Human | Esophagus | ESCC | 1.66e-02 | 3.38e-02 | 0.116 |
26873 | OPLAH | P12T-E | Human | Esophagus | ESCC | 6.86e-21 | 3.99e-01 | 0.1122 |
26873 | OPLAH | P15T-E | Human | Esophagus | ESCC | 1.03e-05 | 1.42e-01 | 0.1149 |
26873 | OPLAH | P16T-E | Human | Esophagus | ESCC | 4.19e-25 | 3.34e-01 | 0.1153 |
26873 | OPLAH | P20T-E | Human | Esophagus | ESCC | 2.97e-06 | 1.56e-01 | 0.1124 |
26873 | OPLAH | P21T-E | Human | Esophagus | ESCC | 1.85e-18 | 3.14e-01 | 0.1617 |
26873 | OPLAH | P22T-E | Human | Esophagus | ESCC | 6.33e-10 | 7.34e-02 | 0.1236 |
26873 | OPLAH | P23T-E | Human | Esophagus | ESCC | 1.48e-02 | 1.25e-01 | 0.108 |
26873 | OPLAH | P24T-E | Human | Esophagus | ESCC | 3.50e-02 | 7.63e-02 | 0.1287 |
26873 | OPLAH | P26T-E | Human | Esophagus | ESCC | 1.38e-06 | 1.09e-01 | 0.1276 |
26873 | OPLAH | P27T-E | Human | Esophagus | ESCC | 1.78e-03 | 9.46e-02 | 0.1055 |
26873 | OPLAH | P28T-E | Human | Esophagus | ESCC | 1.12e-12 | 2.30e-01 | 0.1149 |
26873 | OPLAH | P30T-E | Human | Esophagus | ESCC | 1.51e-07 | 2.26e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00065757 | Esophagus | ESCC | cellular modified amino acid metabolic process | 112/8552 | 188/18723 | 8.31e-05 | 6.06e-04 | 112 |
GO:000674912 | Esophagus | ESCC | glutathione metabolic process | 42/8552 | 64/18723 | 1.01e-03 | 5.12e-03 | 42 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:000657521 | Liver | HCC | cellular modified amino acid metabolic process | 119/7958 | 188/18723 | 6.47e-09 | 1.67e-07 | 119 |
GO:000674911 | Liver | HCC | glutathione metabolic process | 44/7958 | 64/18723 | 1.95e-05 | 2.09e-04 | 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0048018 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0048019 | Esophagus | ESCC | Glutathione metabolism | 44/4205 | 57/8465 | 1.81e-05 | 9.03e-05 | 4.63e-05 | 44 |
hsa0048022 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
hsa0048032 | Liver | HCC | Glutathione metabolism | 42/4020 | 57/8465 | 5.00e-05 | 2.62e-04 | 1.46e-04 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OPLAH | SNV | Missense_Mutation | novel | c.1180N>A | p.Ala394Thr | p.A394T | O14841 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-FV-A23B-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
OPLAH | SNV | Missense_Mutation | novel | c.3088N>A | p.Val1030Ile | p.V1030I | O14841 | protein_coding | tolerated(1) | benign(0.005) | TCGA-QA-A7B7-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
OPLAH | SNV | Missense_Mutation | rs782205791 | c.905N>G | p.Tyr302Cys | p.Y302C | O14841 | protein_coding | deleterious(0) | benign(0.06) | TCGA-05-4397-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OPLAH | SNV | Missense_Mutation | novel | c.3823N>T | p.His1275Tyr | p.H1275Y | O14841 | protein_coding | deleterious(0) | benign(0) | TCGA-44-2662-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Other, specify in notesGSK Mage Vaccine Study | rec | PD |
OPLAH | SNV | Missense_Mutation | novel | c.2793N>C | p.Gln931His | p.Q931H | O14841 | protein_coding | tolerated(0.28) | benign(0.022) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
OPLAH | SNV | Missense_Mutation | novel | c.2831N>G | p.Tyr944Cys | p.Y944C | O14841 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
OPLAH | SNV | Missense_Mutation | rs782637342 | c.1268N>T | p.Ser423Phe | p.S423F | O14841 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
OPLAH | SNV | Missense_Mutation | novel | c.980N>A | p.Gly327Glu | p.G327E | O14841 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD |
OPLAH | SNV | Missense_Mutation | novel | c.2015A>G | p.Gln672Arg | p.Q672R | O14841 | protein_coding | tolerated(0.42) | benign(0.001) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
OPLAH | SNV | Missense_Mutation | novel | c.1567G>A | p.Ala523Thr | p.A523T | O14841 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26873 | OPLAH | ENZYME | MELPHALAN | MELPHALAN | 9751079 |
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