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Gene: OPCML |
Gene summary for OPCML |
Gene summary. |
Gene information | Species | Human | Gene symbol | OPCML | Gene ID | 4978 |
Gene name | opioid binding protein/cell adhesion molecule like | |
Gene Alias | IGLON1 | |
Cytomap | 11q25 | |
Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | Q14982 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4978 | OPCML | HTA11_866_2000001011 | Human | Colorectum | AD | 1.82e-03 | 1.06e-01 | -0.1001 |
4978 | OPCML | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.68e-03 | 1.73e-01 | -0.059 |
4978 | OPCML | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.97e-27 | 1.13e+00 | 0.0112 |
4978 | OPCML | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.43e-15 | 4.91e-01 | 0.0588 |
4978 | OPCML | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.99e-02 | 4.77e-01 | 0.3487 |
4978 | OPCML | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.03e-09 | 2.48e-01 | 0.3859 |
4978 | OPCML | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.29e-06 | 2.01e-01 | 0.3005 |
4978 | OPCML | Pat04-B | Human | Stomach | GC | 8.51e-05 | 1.92e-01 | -0.1483 |
4978 | OPCML | Pat06-B | Human | Stomach | GC | 8.54e-10 | 2.34e-01 | -0.1961 |
4978 | OPCML | Pat11-B | Human | Stomach | GC | 7.11e-10 | 2.92e-01 | -0.182 |
4978 | OPCML | Pat15-B | Human | Stomach | GC | 2.00e-25 | 5.38e-01 | -0.0778 |
4978 | OPCML | Pat18-B | Human | Stomach | GC | 7.15e-04 | 1.61e-01 | -0.0432 |
4978 | OPCML | Pat24-B | Human | Stomach | GC | 8.07e-05 | 2.14e-01 | -0.1184 |
4978 | OPCML | Pat26-A | Human | Stomach | CSG | 1.95e-05 | 1.76e-01 | -0.2402 |
4978 | OPCML | Pat28-A | Human | Stomach | CSG | 4.94e-15 | 3.29e-01 | -0.2594 |
4978 | OPCML | Pat29-A | Human | Stomach | CAG with IM | 1.57e-13 | 4.61e-01 | -0.2769 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OPCML | SNV | Missense_Mutation | c.761T>C | p.Phe254Ser | p.F254S | Q14982 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-38-4630-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OPCML | SNV | Missense_Mutation | c.869N>T | p.Asp290Val | p.D290V | Q14982 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OPCML | SNV | Missense_Mutation | c.194N>T | p.Arg65Leu | p.R65L | Q14982 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-49-AAR2-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | taxol | CR | |
OPCML | SNV | Missense_Mutation | c.609N>A | p.Ser203Arg | p.S203R | Q14982 | protein_coding | tolerated(0.16) | benign(0.249) | TCGA-55-7725-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OPCML | SNV | Missense_Mutation | novel | c.151G>A | p.Glu51Lys | p.E51K | Q14982 | protein_coding | deleterious(0.04) | benign(0.292) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
OPCML | SNV | Missense_Mutation | c.830N>C | p.Arg277Pro | p.R277P | Q14982 | protein_coding | tolerated(0.24) | benign(0.362) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OPCML | SNV | Missense_Mutation | novel | c.513N>G | p.His171Gln | p.H171Q | Q14982 | protein_coding | tolerated(0.08) | benign(0.098) | TCGA-83-5908-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OPCML | SNV | Missense_Mutation | novel | c.613N>G | p.Leu205Val | p.L205V | Q14982 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-91-6836-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OPCML | SNV | Missense_Mutation | rs762120321 | c.212N>T | p.Arg71Leu | p.R71L | Q14982 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OPCML | SNV | Missense_Mutation | c.133G>T | p.Val45Leu | p.V45L | Q14982 | protein_coding | tolerated(0.18) | benign(0.061) | TCGA-21-5786-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4978 | OPCML | DRUGGABLE GENOME | methylphenidate | METHYLPHENIDATE | 29382897 |
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